プロパンジオール脱水酵素、プロパンジオールデヒドラターゼ
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/20 03:35:53」(JST)
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| propanediol dehydratase |
| Identifiers |
| EC number |
4.2.1.28 |
| CAS number |
9026-90-8 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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In enzymology, a propanediol dehydratase (EC 4.2.1.28) is an enzyme that catalyzes the chemical reaction
- propane-1,2-diol propanal + H2O
Hence, this enzyme has one substrate, 1,2-propanediol, and two products, propanal and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is propane-1,2-diol hydro-lyase (propanal-forming). Other names in common use include meso-2,3-butanediol dehydrase, diol dehydratase, DL-1,2-propanediol hydro-lyase, diol dehydrase, adenosylcobalamin-dependent diol dehydratase, propanediol dehydrase, coenzyme B12-dependent diol dehydrase, 1,2-propanediol dehydratase, dioldehydratase, and propane-1,2-diol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobamide.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1DIO, 1EEX, 1EGM, 1EGV, 1IWB, 1UC4, and 1UC5.
References
- ABELES RH, LEE HA Jr (1961). "An intramolecular oxidation-reduction requiring a cobamide coenzyme". J. Biol. Chem. 236: 2347–50. PMID 13680987.
- Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149 (2): 413–9. PMC 216523. PMID 7035429.
- LEE HA Jr, ABELES RH (1963). "Purification and properties of dioldehydrase, and enzyme requiring a cobamide coenzyme". J. Biol. Chem. 238: 2367–73. PMID 13929077.
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Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)
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| 4.2.1: Hydro-Lyases |
- Carbonic anhydrase
- Fumarase
- Aconitase
- Enolase
- Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase
- Methylglutaconyl-CoA hydratase
- Tryptophan synthase
- Cystathionine beta synthase
- Porphobilinogen synthase
- 3-Isopropylmalate dehydratase
- Urocanase
- Uroporphyrinogen III synthase
- Nitrile hydratase
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| 4.2.2: Acting on polysaccharides |
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| 4.2.3: Acting on phosphates |
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| 4.2.99: Other |
- Carboxymethyloxysuccinate lyase
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Proteins: enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- Production of 3-hydroxypropionic acid from glycerol by recombinant Klebsiella pneumoniae ΔdhaTΔyqhD which can produce vitamin B(12) naturally.
- Ashok S, Sankaranarayanan M, Ko Y, Jae KE, Ainala SK, Kumar V, Park S.SourceDepartment of Chemical and Biomolecular Engineering, Pusan National University, San 30, Jangjeon-dong, Geumjeong-gu, Busan 609-735, South Korea; telephone: +82-51-510-3049; fax: +82-51-515-2716.
- Biotechnology and bioengineering.Biotechnol Bioeng.2012 Sep 5. doi: 10.1002/bit.24726. [Epub ahead of print]
- 3-Hydroxypropionic acid (3-HP) is an important platform chemical that can be used to synthesize a range of chemical compounds. A previous study demonstrated that recombinant Escherichia coli stains can produce 3-HP from glycerol in the presence of vitamin B(12) (coenzyme B(12) ), when overexpressed
- PMID 22952017
- Molecular Cloning, Co-expression, and Characterization of Glycerol Dehydratase and 1,3-Propanediol Dehydrogenase from Citrobacter freundii.
- Qi X, Deng W, Wang F, Guo Q, Chen H, Wang L, He X, Huang R.SourceSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China, qxh@ujs.edu.cn.
- Molecular biotechnology.Mol Biotechnol.2012 Jul 22. [Epub ahead of print]
- 1,3-Propanediol (1,3-PD), an important material for chemical industry, is biologically synthesized by glycerol dehydratase (GDHt) and 1,3-propanediol dehydrogenase (PDOR). In present study, the dhaBCE and dhaT genes encoding glycerol dehydratase and 1,3-propanediol dehydrogenase respectively were cl
- PMID 22821086
Japanese Journal
- 有用細菌(乳酸菌等)の全ゲノム塩基配列決定,比較ゲノム解析および有用遺伝子の機能解明 : 第2報(フロンティア,平成15年度麻布大学公的研究助成金事業研究成果報告)
- 森田 英利,政岡 俊夫,茅根 士郎,和田 恭則,有嶋 和義,木内 明男,坂田 亮一,紫野 正雄,内藤 博之,斉藤 康秀,西田 利穂,印牧 信行,滝沢 達也,加藤 行男,村上 賢,福山 正文,岸川 正剛,久松 伸,吉村 哲彦,柴 忠義,服部 正平
- 麻布大学雑誌 9/10, 250-254, 2004
- … reuteriは, glycerol dehydratase (GD; … 本菌株のグリセロール代謝は,グリセロールをGDによってロイテリンに変換し,1,3-propanediol dehydrogenase(EC 1.1.1.202)によって1,3-プロパンジオールに還元する還元反応系と,グリセロールをglycerol dehydrogenase(EC 1.1.1.6)によってジヒドロキシアセトンに変換する酸化反応系の2つの酸化還元反応系で構成されていると考えられる。 …
- NAID 110004830053
- The crystal structure of coenzyme B_<12>-dependent glycerol dehydratase in complex with cobalamin and 1, 2-propanediol
Related Links
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- Research Grants, Genomes and Genes, Research Topics, Species, Scientific Experts, Publications about propanediol dehydratase ... ..A modeling study based on the crystal structures of enzymes and reactivating factors also ...
★リンクテーブル★
[★]
- 英
- propanediol dehydratase
- 関
- プロパンジオールデヒドラターゼ
[★]
- 英
- propanediol dehydratase
- 関
- プロパンジオール脱水酵素
[★]
- 関
- anhydrase、dehydrase、hydrase、hydro-lyase
[★]
プロパンジオール
- 関
- propylene glycol