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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/23 23:52:08」(JST)

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Proglucagon is a protein that is cleaved from preproglucagon. Preproglucagon in humans is encoded by the GCG gene.^[1]^[2]

Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. It is cleaved into the following components:

Glicentin
Glicentin-related pancreatic polypeptide (GRPP)
Oxyntomodulin (OXY or OXM)
Glucagon
Glucagon-like peptide 1 (GLP-1)
Glucagon-like peptide 2 (GLP-2)

References

^ Schroeder WT, Lopez LC, Harper ME, Saunders GF (1984). "Localization of the human glucagon gene (GCG) to chromosome segment 2q36–37". Cytogenet. Cell Genet. 38 (1): 76–9. doi:10.1159/000132034. PMID 6546710.
^ White JW, Saunders GF (June 1986). "Structure of the human glucagon gene". Nucleic Acids Res. 14 (12): 4719–30. doi:10.1093/nar/14.12.4719. PMC 311486. PMID 3725587.

External links

Diagram at nature.com
Overview at lawsonimaging.ca
Diagram at phoenixpeptide.com
Diagram at phoenixpeptide.com
Diagram at medscape.com

UpToDate Contents

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English Journal

Type 2 Diabetes, SGLT2 Inhibitors, and Glucose Secretion.

Hattersley AT, Thorens B.
The New England journal of medicine.N Engl J Med.2015 Sep 3;373(10):974-6. doi: 10.1056/NEJMcibr1506573.
PMID 26332554

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.

Solomou A1, Meur G1, Bellomo E1, Hodson DJ1, Tomas A2, Migrenne Li S3, Philippe E3, Herrera PL4, Magnan C3, Rutter GA5.
The Journal of biological chemistry.J Biol Chem.2015 Aug 28;290(35):21432-42. doi: 10.1074/jbc.M115.645291. Epub 2015 Jul 15.
SLC30A8 encodes a zinc transporter ZnT8 largely restricted to pancreatic islet β- and α-cells, and responsible for zinc accumulation into secretory granules. Although common SLC30A8 variants, believed to reduce ZnT8 activity, increase type 2 diabetes risk in humans, rare inactivating mutations are
PMID 26178371

Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial.

Davies MJ, Bergenstal R, Bode B, Kushner RF, Lewin A, Skjøth TV, Andreasen AH, Jensen CB, DeFronzo RA; NN8022-1922 Study Group.
JAMA.JAMA.2015 Aug 18;314(7):687-99. doi: 10.1001/jama.2015.9676.
IMPORTANCE: Weight loss of 5% to 10% can improve type 2 diabetes and related comorbidities. Few safe, effective weight-management drugs are currently available.OBJECTIVE: To investigate efficacy and safety of liraglutide vs placebo for weight management in adults with overweight or obesity and type
PMID 26284720

Japanese Journal

Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks

The Journal of Poultry Science advpub(0), 2015
NAID 130005130352

Glucagon-like Peptide-2 Functions as an Anorexigenic Peptide not only in the Central Nervous System but also in the Peripheral Circulation in Broiler Chicks