English Journal

Colocalization of insulin and glucagon in insulinoma cells and developing pancreatic endocrine cells.

Wang Z1, You J1, Xu S1, Hua Z2, Zhang W1, Deng T1, Fang N3, Fang Q1, Liu H1, Peng L1, Wang P4, Lou J5.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Jun 12;461(4):598-604. doi: 10.1016/j.bbrc.2015.04.072. Epub 2015 Apr 23.
A significant portion of human and rat insulinomas coexpress multiple hormones. This character termed as multihormonality is also observed in some early pancreatic endocrine cells which coexpress insulin and glucagon, suggesting an incomplete differentiation status of both cells. Here we demonstrate
PMID 25912877

Effects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. on GLP-1 expression and secretion in vivo and in vitro.

Liu YX1, Si MM1, Lu W2, Zhang LX2, Zhou CX3, Deng SL4, Wu HS5.
Journal of ethnopharmacology.J Ethnopharmacol.2015 May 26;166:168-75. doi: 10.1016/j.jep.2015.03.014. Epub 2015 Mar 17.
ETHNOPHARMACOLOGICAL RELEVANCE: The radix of Acorus calamus L. (AC) is widely used in diabetes therapies in traditional folk medicine from America and Indonesia, and we have previously reported that the ethyl acetate fraction of AC (ACE) acts as an antidiabetic through insulin sensitizing, insulin r
PMID 25792018

Glucocorticoids decrease the production of glucagon-like peptide-1 at the transcriptional level in intestinal L-cells.

Sato T1, Hayashi H1, Hiratsuka M1, Hirasawa N2.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 May 5;406:60-7. doi: 10.1016/j.mce.2015.02.014. Epub 2015 Feb 17.
Glucocorticoids are widely used as anti-inflammatory or immunosuppressive drugs, but often induce hyperglycemia as a side effect. Glucagon-like peptide-1 (GLP-1) is secreted from intestinal L cells and plays crucial roles in maintaining glucose homeostasis. However, the direct effects of glucocortic
PMID 25700603

Japanese Journal

Kihira Yoshitaka,Burentogtokh Ariunzaya,Itoh Mari [他],Izawa-Ishizawa Yuki,Ishizawa Keisuke,Ikeda Yasumasa,Tsuchiya Koichiro,Tamaki Toshiaki
Biological and Pharmaceutical Bulletin 38(4), 514-521, 2015
… Forskolin-stimulated elevations of preproglucagon (ppGCG) and proprotein convertase 1/3 (PC1/3) mRNA expression were decreased under hypoxic conditions. …
NAID 130005062264