English Journal
- New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study.
- Ishikura H, Nishida T, Murai A, Nakamura Y, Irie Y, Tanaka J, Umemura T.AbstractINTRODUCTION: Inflammation and coagulation are closely interrelated pathophysiologic processes in the pathogenesis of sepsis. However, the diagnostic criteria of sepsis and disseminated intravascular coagulation (DIC) are different. This study aimed to define a biomarker panel to predict sepsis-induced DIC in emergency department patients.
- Critical care (London, England).Crit Care.2014 Jan 20;18(1):R19. [Epub ahead of print]
- INTRODUCTION: Inflammation and coagulation are closely interrelated pathophysiologic processes in the pathogenesis of sepsis. However, the diagnostic criteria of sepsis and disseminated intravascular coagulation (DIC) are different. This study aimed to define a biomarker panel to predict sepsis-indu
- PMID 24443891
- Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial.
- Masson S, Caironi P, Spanuth E, Thomae R, Panigada M, Sangiorgi G, Fumagalli R, Mauri T, Isgrò S, Fanizza C, Romero M, Tognoni G, Latini R, Gattinoni L.AbstractINTRODUCTION: Sepsis, a leading cause of death in critically ill patients, is the result of complex interactions between the infecting microorganisms and the host responses that influence clinical outcomes. We evaluated the prognostic value of presepsin (sCD14-ST), a novel biomarker of bacterial infection, and compared it with procalcitonin.
- Critical care (London, England).Crit Care.2014 Jan 7;18(1):R6. [Epub ahead of print]
- INTRODUCTION: Sepsis, a leading cause of death in critically ill patients, is the result of complex interactions between the infecting microorganisms and the host responses that influence clinical outcomes. We evaluated the prognostic value of presepsin (sCD14-ST), a novel biomarker of bacterial inf
- PMID 24393424
- Presepsin (sCD14-ST) in emergency department: the need for adapted threshold values?
- Chenevier-Gobeaux C, Trabattoni E, Roelens M, Borderie D, Claessens YE.Author information Groupe Hospitalier Cochin-Broca-Hôtel Dieu, APHP, Department of Biochemistry, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France. Electronic address: camille.gobeaux@cch.aphp.fr.AbstractPresepsin is elevated in patients developing infections and increases in a severity-dependent manner. We aimed to evaluate circulating values of this new biomarker in a population free of any acute infectious disorder. We recruited 144 consecutive patients presenting at the emergency department (ED) without acute infection or acute/unstable disorder, and 54 healthy participants. Presepsin plasmatic concentrations were measured on the PATHFAST point-of-care analyzer. The 95th percentile of presepsin values in the ED population is 750ng/L. Presepsin was significantly increased in patients aged ≥70years vs. younger patients (470 [380-601] ng/L vs. 300 [201-457] ng/L, p<0.001). Prevalence of elevated presepsin values was increased in patients in comparison to controls (80% vs.13%, p<0.001), and in patients aged ≥70years in comparison to younger patients (87% vs. 47%, p<0.001). Presepsin concentrations were significantly increased in patients with kidney dysfunction. Aging was an independent predictor of an elevated presepsin value. In conclusion, presepsin concentrations increase with age and kidney dysfunction. Therefore interpretation of presepsin concentrations might be altered in the elderly or in patients with impaired renal function. Adapted thresholds are needed for specific populations.
- Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2014 Jan 1;427:34-6. doi: 10.1016/j.cca.2013.09.019. Epub 2013 Sep 27.
- Presepsin is elevated in patients developing infections and increases in a severity-dependent manner. We aimed to evaluate circulating values of this new biomarker in a population free of any acute infectious disorder. We recruited 144 consecutive patients presenting at the emergency department (ED)
- PMID 24076253
Japanese Journal
- 全身性細菌感染症の評価とバイオマーカー(プロカルシトニン,プレセプシン) (特集 重症感染症の病態と治療 : 最近の進歩)
- 佐藤 康次,谷口 巧
- ICUとCCU = Japanese journal of intensive care medicine : 集中治療医学 37(4), 249-254, 2013-04
- NAID 40019688167
- 外科感染症におけるプレセプシン(可溶性CD14 subtype)の有用性 (特集 外科感染症における分子生物学的研究) -- (敗血症診断・治療におけるバイオマーカーの役割)
- 福井 康雄
- 日本外科感染症学会雑誌 9(4), 301-305, 2012-08
- NAID 40019434623
- 敗血症性急性呼吸不全と液性因子
- 遠藤 重厚,高橋 学,小鹿 雅博 [他],松本 尚也,柴田 繁啓,鈴木 泰,井上 義博
- 岩手医学雑誌 64(2), 71-88, 2012-06-01
- NAID 110009421646
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