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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/14 17:34:40」(JST)

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PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.

Shizu R1, Abe T2, Benoki S1, Takahashi M3, Kodama S1, Miayata M1, Matsuzawa A4, Yoshinari K5.
The Biochemical journal.Biochem J.2016 Feb 1;473(3):257-66. doi: 10.1042/BJ20150734. Epub 2015 Nov 16.
Growth factor-mediated hepatocyte proliferation is crucial in liver regeneration and the recovery of liver function after injury. The nuclear receptor, pregnane X receptor (PXR), is a key transcription factor for the xenobiotic-induced expression of genes associated with various liver functions. Rec
PMID 26574435

A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production.

Muta K1, Fukami T2, Nakajima M1.
Biochemical pharmacology.Biochem Pharmacol.2015 Dec 15;98(4):659-70. doi: 10.1016/j.bcp.2015.09.016. Epub 2015 Sep 25.
Acebutolol, a β-adrenergic receptor-blocker, occasionally causes drug-induced lupus erythematosus (DILE). Acebutolol is mainly metabolized to diacetolol. Because metabolic activation has been considered to be related to acebutolol-induced toxicity, we sought to identify the enzymes that are respons
PMID 26408002

Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators.

Baker AA1, Guo GL1,2, Aleksunes LM1,2, Richardson JR3,4.
Journal of biochemical and molecular toxicology.J Biochem Mol Toxicol.2015 Dec;29(12):545-51. doi: 10.1002/jbt.21725. Epub 2015 Jul 15.
Nuclear receptors and transcription factors regulate the mRNA expression of many drug metabolizing enzymes, including the carboxylesterases (Ces). However, there are few data regarding whether these changes in mRNA expression result in alteration of protein levels or activity. In the present study,
PMID 26179144

Identification of candidate target Cyp genes for microRNAs whose expression is altered by PCN and TCPOBOP, representative ligands of PXR and CAR

Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor

リンク元	「pregnenolone 16alpha-carbonitrile」「プレグネノロンカルボニトリル」
関連記事	「pregnenolone」

Pregnenolone carbonitrile
	IUPAC name (3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
Identifiers
CAS number	1434-54-4
PubChem	15032
ChEMBL	CHEMBL1400945
Jmol-3D images	Image 1
	SMILES CC(=O)[C@H]1[C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C#N ;
Properties
Molecular formula	C22H31NO2
Molar mass	341.49 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references