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1. 腎尿細管性アシドーシスの概要と病態生理、およびカリウムバランスへの影響overview and pathophysiology of renal tubular acidosis and the effect on potassium balance [show details]
… collecting tubules via a luminal H-ATPase pump and, to a lesser degree, via an H-K-ATPase pump that secretes hydrogen ions and reabsorbs potassium By contrast, potassium secretion occurs primarily by the …
2. 赤血球水分量の制御control of red blood cell hydration [show details]
…sodium, potassium, and Cl content and the osmolality of the plasma. There are two active transport systems in the red cell: the Na-K-ATPase pump and the calcium-ATPase pump. Sodium-potassium ATPase is an …
3. 低マグネシウム血症の原因causes of hypomagnesemia [show details]
…expression of the gamma subunit of Na-K-ATPase and the potassium channel Kir5.1 . These findings suggest that some inactivating mutations of HNF-1-beta can inhibit the Na-K-ATPase and Kir5.1, thereby causing hypomagnesemia …
4. 成人における高カリウム血症の原因および評価causes and evaluation of hyperkalemia in adults [show details]
… secretory potassium channels . Increased Na-K-ATPase activity, which enhances potassium uptake into the cell across the basolateral (peritubular) membrane, thereby increasing the size of the potassium secretory …
5. 甲状腺中毒性周期性四肢麻痺thyrotoxic periodic paralysis [show details]
…stimulation, which, along with thyroid hormone, increases sodium-potassium ATPase activity on the skeletal muscle membrane . This tends to drive potassium into cells, perhaps leading to hyperpolarization of the …

English Journal

NMR shutter-speed elucidates apparent population inversion of H O signals due to active transmembrane water cycling.

Li X, Mangia S, Lee JH, Bai R, Springer CS.
Magnetic resonance in medicine. 2019 Jul;82(1)411-424.
The desire to quantitatively discriminate the extra- and intracellular tissue H O MR signals has gone hand-in-hand with the continual, historic increase in MRI instrument magnetic field strength [B ]. However, recent studies have indicated extremely valuable, novel metabolic information can be read
PMID 30903632

A multibiomarker approach for evaluating environmental contamination: Common carp (Cyprinus carpio) transplanted along a gradient of metal pollution.

Delahaut V, Daelemans O, Sinha AK, De Boeck G, Bervoets L.
The Science of the total environment. 2019 Jun;669()481-492.
Environmental monitoring and risk assessment approaches which include a more holistic view on the effects of pollutants on biota are increasingly sought by regulators and policy makers. Therefore, caged carp juveniles (Cyprinus carpio) were transplanted for 7 weeks along a known Cd and Zn pollutio
PMID 30884270

Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.

Amarelle L, Katzen J, Shigemura M, Welch LC, Cajigas H, Peteranderl C, Celli D, Herold S, Lecuona E, Sznajder JI.
American journal of physiology. Lung cellular and molecular physiology. 2019 Jun;316(6)L1094-L1106.
Cardiac glycosides (CGs) are used primarily for cardiac failure and have been reported to have other effects, including inhibition of viral replication. Here we set out to study mechanisms by which CGs as inhibitors of the Na-K-ATPase decrease influenza A virus (IAV) replication in the lungs. We fou
PMID 30892074

Japanese Journal

新規カリウムイオン競合型アシッドブロッカー（P-CAB）ボノプラザンフマル酸塩の合成研究

有川泰由
有機合成化学協会誌 77(3), 254-261, 2019
… The major target in the pharmacological treatment for acid related diseases is the gastric proton pump enzyme H+,K+-ATPase which is responsible for acid secretion. …
NAID 130007608452

Effect of exposure to low salinity water on plasma ion regulation and survival rates in artificially wounded devil stinger Inimicus japonicus

Kawaguchi Osamu,Midooka Anise,Iwamoto Yuji,Kudoh Takaya,Iida Yoshisuke,Nagao Norio,Matsumoto Takuya
Fisheries science 84(3), 477-484, 2018-05
NAID 40021546908

新規カリウムイオン競合型アシッドブロッカーボノプラザンフマル酸塩の薬理学的特性と臨床効果

松川純,稲富信博,西田晴行,月見泰博
日本薬理学雑誌 152(3), 104-110, 2018
… プロトンポンプ阻害薬（PPI）は，哺乳類の胃壁細胞に選択的に局在し，かつ酸分泌の最終段階を担う酵素であるH＋, K＋-ATPase（プロトンポンプ）に対して共有結合を形成し，活性を不可逆的に阻害する．PPIは制酸薬やヒスタミンH2受容体拮抗薬などと比較して，優れた臨床効果を示すことから，長期にわたって酸関連疾患治療の第一選択薬として用いられてきた …
NAID 130007472330