polysomal

English Journal

Introduction to Bioinformatics Resources for Post-transcriptional Regulation of Gene Expression.

Quattrone A1, Dassi E2.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1358:3-28. doi: 10.1007/978-1-4939-3067-8_1.
Untranslated regions (UTRs) and, to a lesser extent, coding sequences of mRNAs are involved in defining the fate of the mature transcripts through the modulation of three primary control processes, mRNA localization, degradation and translation; the action of trans-factors such as RNA-binding protei
PMID 26463374

The effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype.

Dieudonné FX1, O'Connor PB2, Gubler-Jaquier P1, Yasrebi H1, Conne B1,3, Nikolaev S3, Antonarakis S3,4, Baranov PV2, Curran J5,6.
BMC genomics.BMC Genomics.2015 Nov 21;16(1):986. doi: 10.1186/s12864-015-2179-8.
BACKGROUND: The genetic program, as manifested as the cellular phenotype, is in large part dictated by the cell's protein composition. Since characterisation of the proteome remains technically laborious it is attractive to define the genetic expression profile using the transcriptome. However, the
PMID 26589636

The CDKN2A/p16INK 4a 5'UTR sequence and translational regulation: impact of novel variants predisposing to melanoma.

Andreotti V1,2, Bisio A3, Bressac-de Paillerets B4, Harland M5, Cabaret O4, Newton-Bishop J5, Pastorino L1,2, Bruno W1,2, Bertorelli R6, De Sanctis V6, Provenzani A7, Menin C8, Fronza G9, Queirolo P10, Spitale RC11, Bianchi-Scarrà G1,2, Inga A3, Ghiorzo P1,2.
Pigment cell & melanoma research.Pigment Cell Melanoma Res.2015 Nov 18. doi: 10.1111/pcmr.12444. [Epub ahead of print]
Many variants of uncertain functional significance in cancer susceptibility genes lie in regulatory regions, and clarifying their association with disease risk poses significant challenges. We studied 17 germline variants (9 of which were novel) in the CDKN2A 5'UTR with independent approaches, which
PMID 26581427

3P345 原子間力顕微鏡を用いたポリソームプロファイルによる翻訳過程における開始確率と伸長速度の評価(バイオイメージング、行動、発生・分化、分子遺伝、その他,口頭発表,第45回日本生物物理学会年会)

P1-IS-30 The polysomal RNA from ovarian cancers can stimulate tumor antigen-specific immunity.