WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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Primary afferent neurons containing calcitonin gene-related peptide but not substance P in forepaw skin, dorsal root ganglia, and spinal cord of mice.

Kestell GR1, Anderson RL1, Clarke JN1, Haberberger RV1, Gibbins IL1.
The Journal of comparative neurology.J Comp Neurol.2015 Dec 1;523(17):2555-69. doi: 10.1002/cne.23804. Epub 2015 Jun 11.
In mice dorsal root ganglia (DRG), some neurons express calcitonin gene-related peptide (CGRP) without substance P (SP; CGRP(+) SP(-) ). The projections and functions of these neurons are unknown. Therefore, we combined in vitro axonal tracing with multiple-labeling immunohistochemistry to neurochem
PMID 26010480

A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice.

Miyanohara J1, Shirakawa H2, Sanpei K1, Nakagawa T3, Kaneko S1.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Nov 20;467(3):478-83. doi: 10.1016/j.bbrc.2015.10.027. Epub 2015 Oct 8.
Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel with high Ca(2+) permeability, which functions as a polymodal nociceptor activated by heat, protons and several vanilloids, including capsaicin and anandamide. Although TRPV1 channels are widely distributed in the mam
PMID 26456642

Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel.

Bidaux G1, Sgobba M2, Lemonnier L3, Borowiec AS3, Noyer L3, Jovanovic S4, Zholos AV5, Haider S6.
Biophysical journal.Biophys J.2015 Nov 3;109(9):1840-51. doi: 10.1016/j.bpj.2015.09.027.
Members of the transient receptor potential (TRP) ion channel family act as polymodal cellular sensors, which aid in regulating Ca(2+) homeostasis. Within the TRP family, TRPM8 is the cold receptor that forms a nonselective homotetrameric cation channel. In the absence of TRPM8 crystal structure, li
PMID 26536261

SL2 Introduction of the Japanese acupuncture and possible role of the polymodal receptor in its action mechanisms

KAWAKITA Kenji
日本温泉気候物理医学会雑誌 77(5), 402-403, 2014
… The polymodal receptors (PMRs), which responsive to mechanical, thermal and chemical stimuli, are activated by both acupuncture and moxibustion. … Figure 1 shows schematic illustration of the polymodal receptor hypothesis of action mechanisms of acupuncture and moxibustion. …
NAID 130004719487

Transient Receptor Potential Vanilloid 1-a Polymodal Nociceptive Receptor-Plays a Crucial Role in Formaldehyde-Induced Skin Inflammation in Mice

Usuda Haruki,Endo Takumi,Shimouchi Ayumi [他],SAITO Asaka,TOMINAGA Makoto,YAMASHITA Hirotaka,NAGAI Hiroichi,INAGAKI Naoki,TANAKA Hiroyuki
Journal of pharmacological sciences 118(2), 266-274, 2012-02-20
… In our previous study, we demonstrated that repeated painting of 2% – 10% FA on mouse ears caused marked ear swelling and increased mRNA expression of transient receptor potential vanilloid 1 (TRPV1) and neurotrophins in the ear. …
NAID 10030455105

中川弘,樋浦明夫,Nakagawa Hiroshi,Hiura Akio
四国歯学会雑誌 25(1), 1-10, 2012
… The significance of the discovery of capsaicin receptor, TRPV1, and its characteristic features (polymodal receptor) are discussed based on recent reports, although the sensitization or desensitization mechanisms are not yet resolved. …
NAID 120005267180