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- PHMB
- 同
- PHMB
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- PHMB
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/11 23:33:52」(JST)
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Polyhexanide
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| Names |
| Other names
Polyhexamethylene biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide
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| Identifiers |
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CAS Number
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28757-47-3 N
32289-58-0 (HCl) Y
28757-48-4 N |
| Abbreviations |
PHMB |
| UNII |
322U039GMF Y |
| Properties |
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Chemical formula
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(C8H17N5)n |
| Pharmacology |
| ATC code |
D08AC05 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| N verify (what is YN ?) |
| Infobox references |
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Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use[1] it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, and Omnicide.[2] PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).[3]
Some products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection.[4]
Branded as Baquacil, it also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. It is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Leisure Time Free system.
PHMB is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.
The PHMB hydrochloride salt (solution) is used in the majority of formulations.
See also
- Polyaminopropyl biguanide, a related biguanide disinfectant
References
- ^ Ansorg R, Rath PM, Fabry W (2003). "Inhibition of the anti-staphylococcal activity of the antiseptic polihexanide by mucin". Arzneimittel-Forschung 53 (5): 368–71. doi:10.1055/s-0031-1297121. PMID 12854364.
- ^ International Drug Names: Polihexanide
- ^ Maribeth Cousin, Kimberly Restivo, Chelsea Rodriguez, and Justin Lien. USP Antimicrobial Effectiveness Test (GLP). Elkhorn, WI: Geneva Laboratories. 2013. http://steriwebrx.com/files/STERIWEB-FINAL-JN13J1514.pdf
- ^ Nusept
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Antiseptics and disinfectants (D08)
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| Acridine derivatives |
- Ethacridine lactate
- 9-Aminoacridine
- Euflavine
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| Biguanides and amidines |
- Dibrompropamidine
- Chlorhexidine#
- Propamidine
- Hexamidine
- Polihexanide
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| Phenol and derivatives |
- Hexachlorophene
- Policresulen
- Phenol
- Triclosan
- Chloroxylenol#
- Biphenylol
- Fenticlor
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| Nitrofuran derivatives |
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| Iodine products |
- Iodine/octylphenoxypolyglycolether
- Povidone-iodine#
- Diiodohydroxypropane
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| Quinoline derivatives |
- Dequalinium
- Chlorquinaldol
- Oxyquinoline
- Clioquinol
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| Quaternary ammonium compounds |
- Benzalkonium
- Benzethonium chloride
- Cetrimonium (bromide/chloride)
- Cetylpyridinium
- Cetrimide
- Benzoxonium chloride
- Didecyldimethylammonium chloride
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| Mercurial products |
- Mercuric amidochloride
- Phenylmercuric borate
- Mercuric chloride
- Merbromin
- Thiomersal
- Mercuric iodide
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| Silver compounds |
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| Alcohols |
- Propanol (propyl alcohol)
- Isopropanol (isopropyl alcohol)
- Ethanol (ethyl alcohol)#
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| Other |
- Potassium permanganate
- Sodium hypochlorite
- Hydrogen peroxide
- Eosin
- Tosylchloramide
- Octenidine dihydrochloride
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|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of skin
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|
| Description |
- Anatomy
- Physiology
- Development
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| Disease |
- Infections
- Vesiculobullous
- Dermatitis and eczema
- Papulosquamous
- Urticaria and erythema
- Radiation-related
- Pigmentation
- Mucinoses
- Keratosis, ulcer, atrophy, and necrobiosis
- Vasculitis
- Fat
- Neutrophilic and eosinophilic
- Congenital
- Neoplasms and cancer
- nevi and melanomas
- epidermis
- dermis
- Symptoms and signs
- Terminology
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| Treatment |
- Procedures
- Drugs
- antibiotics
- disinfectants
- emollients and protectives
- itch
- psoriasis
- other
- Wound and ulcer
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UpToDate Contents
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English Journal
- In Vitro Evaluations of Topical Agents to Treat Acanthamoeba Keratitis.
- Sunada A1, Kimura K2, Nishi I2, Toyokawa M2, Ueda A2, Sakata T2, Suzuki T3, Inoue Y4, Ohashi Y3, Asari S5, Iwatani Y3.
- Ophthalmology.Ophthalmology.2014 May 28. pii: S0161-6420(14)00360-1. doi: 10.1016/j.ophtha.2014.04.013. [Epub ahead of print]
- PURPOSE: To evaluate the effectiveness of topical agents for the treatment of Acanthamoeba keratitis (AK).DESIGN: Laboratory research.PARTICIPANTS: Fifty-six Acanthamoeba isolates from 56 patients with clinically proven AK were studied.METHODS: The effectiveness of 7 agents against Acanthamoeba cyst
- PMID 24880905
- Polyhexamethylene biguanide is a relevant sensitizer in wet wipes.
- Leysen J1, Goossens A, Lambert J, Aerts O.
- Contact dermatitis.Contact Dermatitis.2014 May;70(5):323-5. doi: 10.1111/cod.12208.
- PMID 24731091
- Surface roughness and refractive index changes in contact lens induced by lens care systems.
- Lira M1, Franco S, Vazquez-Dorrio JB, Real Oliveira ME, Costa MF.
- Eye & contact lens.Eye Contact Lens.2014 May;40(3):140-7. doi: 10.1097/ICL.0000000000000023.
- PURPOSE: The aim of this study was to analyze the influence of different lens care systems in surface roughness and refractive index (RI) of contact lenses (CL). This information provides us with a better understanding of how care solutions affect CL materials.METHODS: Several CL and three commercia
- PMID 24756118
Japanese Journal
- 塩化セチルピリジニウムまたはポリヘキサメチレンビグアニドを配合した架橋型ハイドロゲルドレッシング材の抗菌特性ならびに生物学的安全性評価
- 抗菌性創傷被覆材の開発に向けたPVAハイドロゲルからの抗菌剤の溶出性制御
- Determination of Polyhexamethylene Biguanide Hydrochloride Using Photometric Colloidal Titration with Crystal Violet as a Color Indicator
- Masadome Takashi,Miyanishi Takaaki,Watanabe Keita [他],UEDA Hiroshi,HATTORI Toshiaki
- Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 27(8), 817-821, 2011-08-10
- NAID 10029600261
Related Links
- Polyhexamethylene Biguanide (PHMB). Product Stewardship Summary. April 2008. Chemical Name: Polyhexamethylene biguanide. Synonyms: Poly( hexamethylene) biguanide hydrochloride; polymeric biguanide hydrochloride; ...
- Polyhexamethylene biguanide; Polyhexamethylene guanide; ... Polyhexanide ( polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. ... Polyaminopropyl biguanide, a related biguanide disinfectant ...
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