English Journal

Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress.

Okiyama W1, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez FJ, Aoyama T.
Journal of hepatology.J Hepatol.2009 Jun;50(6):1236-46. doi: 10.1016/j.jhep.2009.01.025. Epub 2009 Apr 2.
BACKGROUND/AIMS: Alcoholic liver disease (ALD) is one of the leading causes of cirrhosis and yet efficient therapeutic strategies are lacking. Polyenephosphatidylcholine (PPC), a major component of essential phospholipids, prevented alcoholic liver fibrosis in baboons, but its precise mechanism rema
PMID 19398233

Zierenberg O, Grundy SM.
Journal of lipid research.J Lipid Res.1982 Nov;23(8):1136-42.
The metabolic fate of 1 of 3H/14C-labeled dilinoleoglycerophosphocholine was studied in five patients after oral administration. The 3H label was in choline and 14C was in the two linoleic acid residues. More than 90% of both isotopes was absorbed from the intestine. Seventy to 90% of the 3H radioac
PMID 7175371

Studies on CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity in rat arterial wall.

Sasaki N, Matsuoka N, Shirai K, Saito Y, Kumagai A.
Atherosclerosis.Atherosclerosis.1982 Jun;43(2-3):185-95.
The properties of CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CPT) (EC 2.7.8.2.), which catalyzes de novo synthesis of phosphatidylcholine, were studied in rat arterial wall. The optimal pH of CPT of the arterial wall was about 8.5. On subcellular fractionation of the arterial wall, th
PMID 6288057

Japanese Journal

Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress

Okiyama W,Tanaka N,Nakajima T,Tanaka E,Kiyosawa K,Gonzalez FJ,Aoyama T
Journal of Hepatology 50(6), 1236-1246, 2009-06
… Polyenephosphatidylcholine (PPC), a major component of essential phospholipids, prevented alcoholic liver fibrosis in baboons, but its precise mechanism remains uncertain. …
NAID 120001368712