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English Journal
- Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus.
- Nishimura H, Azami Y, Miyagawa M, Hashimoto C, Yoshimura T, Hemmi H.SourceDepartment of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan.
- Journal of biochemistry.J Biochem.2013 Feb 21. [Epub ahead of print]
- The existence of the classical mevalonate (MVA) pathway was examined in the thermoacidophilic archaeon Sulfolobus solfataricus. The pathway is considered uncommon among archaea because the genes of the orthologues of phosphomevalonate kinase (PMK) and/or diphosphomevalonate decarboxylase (DMD) are a
- PMID 23378249
- Multi-target-directed design, syntheses, and characterization of fluorescent bisphosphonate derivatives as multifunctional enzyme inhibitors in mevalonate pathway.
- Gao J, Liu J, Qiu Y, Chu X, Qiao Y, Li D.SourceDepartment of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, PR China.
- Biochimica et biophysica acta.Biochim Biophys Acta.2013 Feb 18. pii: S0304-4165(13)00054-8. doi: 10.1016/j.bbagen.2013.02.011. [Epub ahead of print]
- BACKGROUND: Mevalonate pathway is an important cellular metabolic pathway present in all higher eukaryotes and many bacteria. Four enzymes in mevalonate pathway, including MVK, PMK, MDD, and FPPS, play important regulatory roles in cholesterol biosynthesis and cell proliferation.METHODS: The followi
- PMID 23428571
- Association with soil bacteria enhances p38-dependent infection resistance in Caenorhabditis elegans.
- Montalvo-Katz S, Huang H, Appel MD, Berg M, Shapira M.SourceDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.
- Infection and immunity.Infect Immun.2013 Feb;81(2):514-20. doi: 10.1128/IAI.00653-12. Epub 2012 Dec 10.
- The importance of our inner microbial communities for proper immune responses against invading pathogens is now well accepted, but the mechanisms underlying this protection are largely unknown. In this study, we used Caenorhabditis elegans to investigate such mechanisms. Since very little is known a
- PMID 23230286
Japanese Journal
- Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast
- Doi Akira,Kita Ayako,Kanda Yuki,Uno Takaya,Asami Keita,Satoh Ryosuke,Nakano Kentaro,Sugiura Reiko
- Genes to cells 20(4), 310-323, 2015-04
- … Pmk1, a fission yeast homologue of mammalian ERK MAPK, regulates cell wall integrity, cytokinesis, RNA granule formation and ion homeostasis. … Our screen for vic (viable in the presence of immunosuppressant and chloride ion) mutants identified regulators of the Pmk1 MAPK signaling, including Cpp1 and Rho2, based on the genetic interaction between calcineurin and Pmk1 MAPK. …
- NAID 120005608185
- 細胞表面膜タンパク質Ecm33を介したMAPキナーゼシグナルの制御メカニズムの解明と in vivo Real-time MAPキナーゼシグナルモニタリングシステムの確立
- 高田 宏文
- 薬学雑誌. 乙号 131(8), 1195-1200, 2011
- … We have been studying the Pmk1 MAPK, a homologue of the mammalian ERK/MAPK in fission yeast. … The Pmk1 MAPK regulates cell integrity and cell morphology. … We have previously demonstrated that Atf1, a transcription factor downstream of the stress-activated MAPK pathway, serves also as a target of the Pmk1 MAPK signaling in fission yeast. …
- NAID 130001075908
- コリオリ式質量流量計「ROTAMASS 3シリーズ」
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