関: pipradrol hydrochloride

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/13 17:05:32」(JST)

wiki en

Pipradrol (Meratran) is a mild central nervous system stimulant (norepinephrine-dopamine reuptake inhibitor) that is no longer widely used in most countries due to concerns about its abuse potential. Pipradrol is still used in some European countries, and even rarely in the United States.

History

Pipradrol was developed in the 1940s,^[1] and found use initially for treating obesity.^[2] It was subsequently used for the treatment of a variety of other conditions such as narcolepsy, ADHD, and most particularly for counteracting the symptoms of senile dementia, this being the only application for which it is still used medically.^{[medical citation needed]} Pipradrol proved useful for these applications as its relatively mild stimulant effects gave it a good safety profile compared to stronger stimulants.^{[medical citation needed]} It was also studied as an adjutant treatment for depression and schizophrenia although it was never widely used for these purposes.

Pipradrol was made illegal in many countries in the late 1970s, at the same time as many other drugs which had a history of abuse. The relatively mild stimulant effects of pipradrol meant that it was scheduled under the less restrictive classes in most countries (i.e. Class C in United Kingdom and New Zealand) but was still considered of sufficient abuse potential to be made an illegal drug. It is now an obscure compound that is virtually unknown as an illicit drug of abuse, but is still used for some scientific research, often as a comparison drug for testing other stimulants against.

Dose

Dosage is between 0.5 and 4 milligrams per day, typically taken as a single dose in the morning as the long duration of effects of pipradrol (up to 12 hours) means insomnia can be a problem especially if it is used at higher doses or taken too late in the day.^{[medical citation needed]}

Side effects

Common side effects include insomnia, anorexia, tachycardia, anxiety. Rarer side effects include dry mouth, tremor, hypertension, euphoria, depression, and very rarely psychosis or convulsions.

References

^ Tilford, Charles H; Werner, Harold W U.S. Patent 2,624,739 (1953).
^ Gelvin EP, McGavack TH, Kenigsberg S (1955). "Alpha-(2-piperidyl) benzhydrol hydrochloride (pipradrol) as an adjunct in the dietary management of obesity". N Y State J Med 55 (16): 2336–8. PMID 13244858.

English Journal

Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives.

Simmler LD1, Rickli A1, Schramm Y2, Hoener MC3, Liechti ME4.
Biochemical pharmacology.Biochem Pharmacol.2014 Mar 15;88(2):237-44. doi: 10.1016/j.bcp.2014.01.024. Epub 2014 Jan 28.
Aminoindanes, piperazines, and pipradrol derivatives are novel psychoactive substances found in "Ecstasy" tablets as replacements for 3,4-methylenedioxymethamphetamine (MDMA) or substances sold as "ivory wave." The pharmacology of these MDMA- and methylphenidate-like substances is poorly known. We c
PMID 24486525

Trend analysis of anonymised pooled urine from portable street urinals in central London identifies variation in the use of novel psychoactive substances.

Archer JR1, Dargan PI, Lee HM, Hudson S, Wood DM.
Clinical toxicology (Philadelphia, Pa.).Clin Toxicol (Phila).2014 Mar;52(3):160-5. doi: 10.3109/15563650.2014.885982. Epub 2014 Feb 10.
CONTEXT: There is increasing interest in the analysis of waste water at sewage treatment plants to monitor recreational drug use. This technique is limited for novel psychoactive substances (NPS) due to limited knowledge on their human and bacterial metabolism and stability in waste water. Small stu
PMID 24506433

Designer psychostimulants: Pharmacology and differences.

Iversen L1, White M2, Treble R3.
Neuropharmacology.Neuropharmacology.2014 Jan 20. pii: S0028-3908(14)00022-7. doi: 10.1016/j.neuropharm.2014.01.015. [Epub ahead of print]
More than 200 novel psychoactive drugs have been reported in Europe, with 73 added in 2012 and additional compounds encountered every week in 2013. Many of these are "designer psychostimulants" which aim to mimic the subjective effects of amphetamines, cocaine or 3,4-methylenedioxymethylamphetamine
PMID 24456744

Japanese Journal

Recreational drugs, 3,4-Methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA) and diphenylprolinol, inhibit neurite outgrowth in PC12 cells

Journal of toxicological sciences 35(3), 375-381, 2010-06-01
NAID 10026469818

042308 Doping効果に関する基礎的研究 : マウスの運動パフォーマンスに及ぼすPipradrolの影響(4.運動生理学,一般研究B)

日本体育学会大会号 (38B), 594, 1987-08-15
NAID 110007678759

イヌの骨格筋活動に対する各種薬物の影響 : 単一NMUの放電間隔時系列の解析

神戸大学農学部研究報告 15(2), 401-410, 1983-01-30
NAID 110000410380

Related Pictures

★リンクテーブル★

リンク元	「ピプラドロール」
拡張検索	「pipradrol hydrochloride」

「ピプラドロール」

Pipradrol
Systematic (IUPAC) name
	Diphenyl(piperidin-2-yl)methanol
Legal status
Legal status	CA: Schedule IV; DE: Anlage III (Prescription only); NZ: Class C; UK: Class C; US: Schedule IV;
Identifiers
CAS Number	467-60-7
ATC code	N06BX15 (WHO)
PubChem	CID 10083
ChemSpider	9681
UNII	S6I030E0DA
Chemical data
Formula	C18H21NO
Molar mass	267.37
	SMILES OC(c1ccccc1)(c2ccccc2)C3NCCCC3 ;
	InChI InChI=1S/C18H21NO/c20-18(15-9-3-1-4-10-15,16-11-5-2-6-12-16)17-13-7-8-14-19-17/h1-6,9-12,17,19-20H,7-8,13-14H2 ; Key:XSWHNYGMWWVAIE-UHFFFAOYSA-N ;
(what is this?) (verify)