piperazines

ピペラジン誘導体

WordNet

1. vermifuge used to treat infestations by roundworms or pinworms

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/26 08:28:08」(JST)

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Substituted piperazines are a class of chemical compounds. Some are used as recreational drugs and some are used in scientific research.

List of substituted piperazines

Benzylpiperazines

See also: Benzylpiperazine § Chemical derivatives

• 1-Benzylpiperazine

• 1-Methyl-4-benzylpiperazine

• 1,4-Dibenzylpiperazine

• 3,4-Methylenedioxy-1-benzylpiperazine

• 4-Bromo-2,5-dimethoxy-1-benzylpiperazine

• Methoxypiperamide

• 1-Benzylpiperazine (BZP)
• 1-Methyl-4-benzylpiperazine (MBZP)
• 1,4-Dibenzylpiperazine (DBZP)
• 3,4-Methylenedioxy-1-benzylpiperazine (MDBZP)
• 4-Bromo-2,5-dimethoxy-1-benzylpiperazine (2C-B-BZP)
• Methoxypiperamide (MeOP, MEXP) ((4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone)

Befuraline, fipexide, and piberaline produce benzylpiperazine as a metabolite.

Phenylpiperazines

See also: Phenylpiperazine

ortho-Substituted

• 2-Chlorophenylpiperazine (oCPP)
• 2-Methylphenylpiperazine (oMPP)
• 2-Methoxyphenylpiperazine (oMeOPP)

Enpiprazole is known to produce oMPP as a metabolite.

Enciprazine was initially anticipated to produce oMeOPP as a metabolite, but this turned out not to be the case.

meta-Substituted

• 3-Chlorophenylpiperazine (mCPP)
• 3-Methoxyphenylpiperazine (mMeOPP)
• 3-Trifluoromethylphenylpiperazine (TFMPP)
• 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP)

Trazodone, nefazodone, mepiprazole, and others produce mCPP as a metabolite.

para-Substituted

• 4-Chlorophenylpiperazine (pCPP)
• 4-Fluorophenylpiperazine (pFPP)
• 4-Methylphenylpiperazine (pMPP)
• 4-Methoxyphenylpiperazine (MeOPP)
• 4-Nitrophenylpiperazine (pNPP)
• 4-Trifluoromethylphenylpiperazine (pTFMPP)

Multiple substitutions

• 2,3-Dichlorophenylpiperazine (DCPP)
• 2,3-Methylphenylpiperazine (DMPP)
• 3-Trifluoromethyl-4-chlorophenylpiperazine (TFMCPP)

Others

• 1-Phenylpiperazine (PP)

Other arylpiperazines

• 1-(1-Naphthyl)piperazine (1-NP)
• 1-(2-Pyrimidinyl)piperazine (1-PP)
• ORG-12962 (1-(5-trifluoromethyl-6-chloropyridin-2-yl)piperazine)
• Quipazine (2-piperazin-1-ylquinoline)

Many azapirones such as buspirone, gepirone, and tandospirone produce 1-PP as a metabolite.

See also

• Substituted α-alkyltryptamine
• Substituted amphetamine
• Substituted cathinone
• Substituted methylenedioxyphenethylamine
• Substituted phenethylamine
• Substituted phenylmorpholine
• Substituted tryptamine

UpToDate Contents

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English Journal

• Substituent effects on cytotoxic activity, spectroscopic property and DNA binding property of naphthalimide derivatives.

• Wang KR1,2, Qian F1, Sun Q1, Ma CL1, Rong RX3, Cao ZR3, Wang XM3, Xiao-Liu L1,2.
• Chemical biology & drug design.Chem Biol Drug Des.2015 Dec 9. doi: 10.1111/cbdd.12698. [Epub ahead of print]
• A series of novel naphthalimide derivaitves NI1-5 containing piperazine moieties (N-(2-hydroxyethyl)piperazine and 1-piperazinepropanol) and piperidine moieties (4-piperidinemethanol, 4-hydroxypiperidine and 4-piperidineethanol) have been synthesized, and evaluated for their cytotoxic activity, spec
• PMID 26648338

• PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.

• Ghonim MA1, Pyakurel K2, Ibba SV2, Wang J2, Rodriguez P3, Al-Khami AA4, Lammi MR5, Kim H2, Zea AH6, Davis C2, Okpechi S2, Wyczechowska D2, Al-Ghareeb K7, Mansy MS7, Ochoa A2, Naura AS2, Boulares AH8.
• Clinical science (London, England : 1979).Clin Sci (Lond).2015 Dec;129(11):951-62. doi: 10.1042/CS20150122. Epub 2015 Jul 23.
• Our laboratory established a role for poly(ADP-ribose)polymerase (PARP) in asthma. To increase the clinical significance of our studies, it is imperative to demonstrate that PARP is actually activated in human asthma, to examine whether a PARP inhibitor approved for human testing such as olaparib bl
• PMID 26205779

• Analysis of anonymized pooled urine in nine UK cities: variation in classical recreational drug, novel psychoactive substance and anabolic steroid use.

• Archer JR1, Hudson S2, Jackson O3, Yamamoto T1, Lovett C1, Lee HM1, Rao S1, Hunter L1, Dargan PI4, Wood DM5.
• QJM : monthly journal of the Association of Physicians.QJM.2015 Dec;108(12):929-33. doi: 10.1093/qjmed/hcv058. Epub 2015 Mar 13.
• BACKGROUND: Analysis of anonymous pooled urine samples from street urinals has been used to demonstrate time-trends in the detection of classical recreational drugs and novel psychoactive substances (NPS).AIM: This study aimed to expand this to undertake a geographical trend analysis of classical re
• PMID 25770158

Japanese Journal

• 違法ドラッグを取り巻く国内外における現状と規制について

• 花尻(木倉) 瑠理,内山 奈穂子,河村 麻衣子 [他],緒方 潤,合田 幸広
• YAKUGAKU ZASSHI 133(1), 31-40, 2013
• … Before 2007, the major compounds distributed in the Japanese illegal drug market were tryptamines, phenethylamines and piperazines. … In their place, cathinone derivatives have been widely distributed, as well as different phenethylamines and piperazines. … They were 13 tryptamines, 17 phenethylamines, 11 cathinones, 4 piperazines, 23 synthetic cannabinoids, 6 alkyl nitrites, 3 other compounds and 1 plant. …
• NAID 130003361889

• SEQUENTIAL THREE-COMPONENT SYNTHESIS OF 1,4-BIS〔TRIAZOLO〔4,5-d〕PYRIMIDIN-7(6H)-ONE〕PIPERAZINES

• Fang Zheng Dong,Wei Xian Hong
• Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 85(11), 2757-2763, 2012-11-01
• NAID 40019465398

• ２００８年度買い上げ違法ドラッグ製品から検出された新規流通デザイナードラッグの同定

• 内山 奈穂子,宮澤 法政,河村 麻衣子 [他],花尻(木倉) 瑠理,合田 幸広
• YAKUGAKU ZASSHI 130(2), 263-270, 2010
• … Subsequently, other psychoactive compounds were also added to this category, 40 substances (classified as 12 tryptamines, 17 phenethylamines, 3 piperazines, 6 alkyl nitrites, 1 diterpene and 1 plant) are controlled as designated substances as of July 2009. …
• NAID 130000171296

Related Links

• Piperazines | FRANK

... pesticides, brake fluid and a variety of materials and products. Piperazine itself is used as a worming agent for pets and farm animals. BZP was originally evaluated as an anti-depressant drug. Now it is found mainly as a ...

• Piperazines' | Define Piperazines' at Dictionary.com

Piperazines' definition, Also called piperazidine [pip-uh-raz-i-deen, -din, pahy-puh-] /ˌpɪp əˈræz ɪˌdin, -dɪn, ˌpaɪ pə-/ (Show IPA). a colorless, crystalline, deliquescent ring compound, C 4 H 1 0 N 2 , prepared by the reaction of ...

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