ピペラシリン-タゾバクタム
WordNet
- a synthetic type of penicillin antibiotic (trade name Pipracil) used for moderate to severe infections (同)Pipracil
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/07 01:22:45」(JST)
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"Zosyn" redirects here. It is not to be confused with any one of a number of different, unrelated drugs whose names begin with "Zo-."
Piperacillin/tazobactam
Combination of |
Piperacillin |
Ureidopenicillin antibiotic |
Tazobactam |
Beta-lactamase inhibitor |
Clinical data |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a694003 |
Pregnancy
category
|
- US: B (No risk in non-human studies)
|
Legal status
|
|
Routes of
administration
|
Intravenous infusion |
Identifiers |
CAS Registry Number
|
123683-33-0 N |
ATC code
|
J01CR05 |
PubChem |
CID: 9918881 |
ChemSpider |
8094523 Y |
ChEMBL |
CHEMBL436129 Y |
N (what is this?) (verify) |
Piperacillin/tazobactam is a combination antibiotic containing the extended-spectrum penicillin antibiotic piperacillin and the β-lactamase inhibitor tazobactam. It is commercially available as Tazocin (Canada, UK, Australia and New Zealand, Italy, marketed by Pfizer), Biopiper TZ (India.,marketed by Biocon ltd) and Zosyn (U.S., by Pfizer inc). The combination has activity against many Gram-positive and Gram-negative pathogens and Pseudomonas aeruginosa.
Contents
- 1 Uses
- 2 Adverse reactions
- 3 Trade names
- 4 References
- 5 External links
Uses
Its main uses are in intensive care medicine (pneumonia, peritonitis), some diabetes-related foot infections, and empirical therapy in febrile neutropenia (e.g., after chemotherapy). The drug is administered intravenously every 6 or 8 hr, typically over 30 min. It may also be administered by continuous infusion over four hours. Prolonged infusions are thought to maximize the time that serum concentrations are above the minimum inhibitory concentration (MIC) of the bacteria implicated in infection.
Adverse reactions
The most common adverse reaction is diarrhea (7% to 11%).[1] One study showed Clostridium difficile-associated diarrhea happened in 4.9% of the patients on piperacillin/tazobactam.[2] One other side effect is inhibition of platelets (thrombocytopenia).[3]
Trade names
Apart from Tazocin and Zosyn, the drug is marketed in various countries under names such as Brodactam, Piptaz, Maxitaz, Kilbac, Trezora, and Biopiper TZ.
References
- ^ http://www.merckmanuals.com/professional/lexicomp/piperacillin%20and%20tazobactam%20sodium.html#N18A778
- ^ Yeung, EYH; Gore JG; Auersperg EV (2012). "A Retrospective Analysis of the Incidence of Clostridium Difficile Associated Diarrhea with Meropenem and Piperacillin-tazobactam" (PDF). International Journal of Collaborative Research on Internal Medicine & Public Health 4 (8): 1567–1576.
- ^ http://onlinelibrary.wiley.com/doi/10.1002/ajh.21536/full
External links
Antibacterials: cell envelope antibiotics (J01C-J01D)
|
|
Intracellular |
- inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
|
|
Glycopeptide |
- inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
|
|
β-lactams/
(inhibit PBP
cross-links) |
|
|
Other |
- polymyxins/detergent
- depolarizing
- hydrolyze NAM-NAG
- Gramicidin
- Isoniazid
- Teixobactin
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of bacterial disease
|
|
Description |
|
|
Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
|
|
Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
- Vaccines
|
|
|
UpToDate Contents
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English Journal
- Risk of acquiring multidrug-resistant Gram-negative bacilli from prior room occupants in the intensive care unit.
- Nseir S, Blazejewski C, Lubret R, Wallet F, Courcol R, Durocher A.SourceIntensive Care Unit, Calmette Hospital, University Hospital of Lille, Lille ?Medical Assessment Laboratory, Lille II University, Lille ?Microbiology Laboratory, Biology and Pathology Centre, University Hospital of Lille, Lille, France.
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect.2011 Aug;17(8):1201-8. doi: 10.1111/j.1469-0691.2010.03420.x. Epub 2010 Dec 13.
- Clin Microbiol Infect 2011; 17: 1201-1208 ABSTRACT: The objective of this prospective cohort study was to determine whether admission to an intensive care unit (ICU) room previously occupied by a patient with multidrug-resistant (MDR) Gram-negative bacilli (GNB) increases the risk of acquiring these
- PMID 21054665
- Impact of previous antibiotic therapy on outcome of Gram-negative severe sepsis.
- Johnson MT, Reichley R, Hoppe-Bauer J, Dunne WM, Micek S, Kollef M.SourceFrom the Department of Pharmacy Practice (MTJ), UIC-College of Pharmacy, Chicago, IL; the Hospital Informatics Group (RR), BJC Healthcare, St Louis, MO; the Laboratory Medicine Department (JH-B, WMD) and the Pharmacy Department, Barnes-Jewish Hospital (SM), St Louis, MO; and the Pulmonary and Critical Care Division (MK), Washington University School of Medicine, St Louis, MO.
- Critical care medicine.Crit Care Med.2011 Aug;39(8):1859-65.
- OBJECTIVE: : To determine whether exposure to antimicrobial agents in the previous 90 days resulted in decreased bacterial susceptibility and increased hospital mortality in patients with severe sepsis or septic shock attributed to Gram-negative bacteremia.DESIGN: : A retrospective cohort study of h
- PMID 21499086
Japanese Journal
- The activity of piperacillin/tazobactam : β-lactamases ; antibiograms and emerging pathogens
- LIVERMORE David M
- 日本化学療法学会雜誌 = Japanese journal of chemotherapy 56, 81, 2008-11-06
- NAID 10024455165
- The role of Piperacillin/Tazobactam ; NP, VAP and HCAP
- MANDELL Lionel
- 日本化学療法学会雜誌 = Japanese journal of chemotherapy 56, 74, 2008-11-06
- NAID 10024455158
Related Links
- Tazobactam / Piperacillin [TAZ / PIPC] タゾバクタム/ピペラシリン, ペニシリン系 1. 商品名 先発品 ゾシン静注用2.25/ゾシン静注用4.5 【大鵬薬品工業, 大正富山医薬品, 富山化学工業】 2. 日本における発売年 2001(平成13)年 ...
- Medscape - Indication-specific dosing for Zosyn, (piperacillin-tazobactam), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. ... Cautions Risk of ...
Related Pictures
★リンクテーブル★
[★]
- 英
- piperacillin-tazobactam
- 商
- ゾシン Zosyn
- 関
- piperacillin-tazobactam、ピペラシリン piperacillin タゾバクタム tazobactam
参考
http://www.weblio.jp/content/%E3%83%94%E3%83%9A%E3%83%A9%E3%82%B7%E3%83%AA%E3%83%B3%E2%80%90%E3%82%BF%E3%82%BE%E3%83%90%E3%82%AF%E3%82%BF%E3%83%A0
http://www.labo-tech.co.jp/iyakuhin/koukinyaku_binran/num09/nm09_06.html