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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/07 20:21:08」(JST)
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L-Phosphoserine |
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IUPAC name
(S)-2-Amino-3-(phosphonooxy)propionic acid
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Identifiers |
CAS number |
407-41-0 Y |
PubChem |
106 |
ChemSpider |
62074 Y |
UNII |
VI4F0K069V Y |
EC-number |
206-986-0 |
DrugBank |
DB04522 |
MeSH |
Phosphoserine |
ChEBI |
CHEBI:15811 Y |
ChEMBL |
CHEMBL284377 Y |
Jmol-3D images |
Image 1 |
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O=P(O)(O)OC[C@@H](C(=O)O)N
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InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 Y
Key: BZQFBWGGLXLEPQ-REOHCLBHSA-N Y
InChI=1/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
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Properties |
Molecular formula |
C3H8NO6P |
Molar mass |
185.073 g/mol |
Melting point |
228 °C, 501 K, 442 °F
|
Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
Phosphoserine is an ester of serine and phosphoric acid. Phosphoserine is a component of many proteins as the result of posttranslational modifications. The phosphorylation of the alcohol functional group in serine to produce phosphoserine is catalyzed by various types of kinases.
It is a normal metabolite found in human biofluids.[1]
References[edit]
- ^ Analysis of free and bound O-phosphoamino acids in urine by gas chromatography with flame photometric detection
English Journal
- Readout of epigenetic modifications.
- Patel DJ, Wang Z.SourceStructural Biology Department, Memorial Sloan-Kettering Cancer Center, New York, New York 10021; email: pateld@mskcc.org.
- Annual review of biochemistry.Annu Rev Biochem.2013 Jun 2;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
- This review focuses on a structure-based analysis of histone posttranslational modification (PTM) readout, where the PTMs serve as docking sites for reader modules as part of larger complexes displaying chromatin modifier and remodeling activities, with the capacity to alter chromatin architecture a
- PMID 23642229
- The Streptococcus thermophilus protein Wzh functions as a phosphotyrosine phosphatase.
- Cefalo AD, Broadbent JR, Welker DL.Sourcea Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322, USA.
- Canadian journal of microbiology.Can J Microbiol.2013 Jun;59(6):391-8. doi: 10.1139/cjm-2013-0094. Epub 2013 Apr 17.
- Amino acid residues that are important for metal binding and catalysis in Gram-positive phosphotyrosine phosphatases were identified in the Wzh protein of Streptococcus thermophilus MR-1C by using sequence comparisons. A His-tagged fusion Wzh protein was purified from Escherichia coli cultures and t
- PMID 23750953
- Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth.
- Suswam EA, Shacka JJ, Walker K, Lu L, Li X, Si Y, Zhang X, Zheng L, Nabors LB, Cao H, King PH.SourceDepartment of Neurology, University of Alabama at Birmingham, 1720 2nd Avenue South, WTI410C, Birmingham, AL, 35294-3300, USA, easuswam@uab.edu.
- Journal of neuro-oncology.J Neurooncol.2013 Jun;113(2):195-205. doi: 10.1007/s11060-013-1112-8. Epub 2013 Mar 25.
- Malignant gliomas rely on the production of certain critical growth factors including VEGF, interleukin (IL)-6 and IL-8, to fuel rapid tumor growth, angiogenesis, and treatment resistance. Post-transcriptional regulation through adenine and uridine-rich elements of the 3' untranslated region is one
- PMID 23525947
Japanese Journal
- Brain Science(106)統合失調症とL-セリン : 稀な症例を通した 統合失調症病態研究
- L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis
- BACHELOR Michael A.,LU Yan,OWENS David M.
- Journal of dermatological science 63(3), 164-172, 2011-09-01
- NAID 10030892444
- QM/MM法を用いたリン酸化反応の遷移状態モデリング
- 李 秀栄,杉田 有治
- 薬学雑誌 131(8), 1171-1182, 2011
- … We perform QM/MM simulations for the reversible phosphorylation of phosphoserine phosphatase (PSP), which belongs to one of the largest phosphotransferase families characterized to data. …
- NAID 130001075905
Related Links
- Rabbit polyclonal antibody to Phosphoserine. Validated for ELISA, ICC/IF, IHC - Wmt, IP & WB, cited in 18 publications ... Target Relevance Changes in the serine/threonine phosphorylation state of a protein in response to various ...
- Phosphoserine is an ester of serine and phosphoric acid. Phosphoserine is a component of many proteins as the result of posttranslational modifications. The phosphorylation of the alcohol functional group in serine to produce ...
Related Pictures
![Phosphoserine (Serine Phosphate)](https://1mg.info/0/c/u/2112.jpg)
![Description L-serine-3D-balls.png](https://1mg.info/0/c/u/2113.jpg)
![File:Phosphoserine.svg - Wikimedia Commons](https://1mg.info/0/c/u/2114.jpg)
![Of Phosphoserine Fraction Isolated By](https://1mg.info/0/c/u/2115.jpg)
![2D Image | 3-Phosphoserine | C3H8NO6P](https://1mg.info/0/c/u/2116.jpg)
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