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1. 遺伝性運動失調の概要overview of the hereditary ataxias [show details]
… the genetic defect alters amino acid incorporation into the subunits of the oxidative phosphorylation system that are synthesized in the mitochondria,… most common causes of intermittent ataxias are the aminoacidurias resulting from mutations in urea cycle enzymes, which lead to hyperammonemia and disorders of pyruvate and lactate metabolism Affected infants …
2. 成人における急速交代性の双極性障害：大うつ病の治療rapid cycling bipolar disorder in adults treatment of major depression [show details]
… episodes and rates of recurrence in rapid cycling and non-rapid cycling patients, and found that an inferior response to medications was more probable in rapid cycling patients (risk ratio 1.4, 95% CI 1.3-1 …
3. 成人における急速交代性の双極性障害：躁病および軽躁の治療rapid cycling bipolar disorder in adults treatment of mania and hypomania [show details]
…pharmacotherapy is often less beneficial for rapid cycling patients than non-rapid cycling patients, and that lithium may be as effective as other drugs for rapid cycling . This topic reviews the treatment of mania …
4. 小児における自転車事故：予防bicycle injuries in children prevention [show details]
… separately. The term "pedal cycle" is defined by the International Classification of Diseases as any road transport vehicle operated solely by pedals. A pedal cycle includes a bicycle, unicycle, or tricycle …
5. 月経周期の評価と排卵時期evaluation of the menstrual cycle and timing of ovulation [show details]
…least expensive method is menstrual cycle charting. This involves recording the days of onset and cessation of menses for several months in succession. Menstrual cycles between 25 and 35 days are generally …

English Journal

Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) - splicing factor axis.

Mole S, Faizo AAA, Hernandez-Lopez H, Griffiths M, Stevenson A, Roberts S, Graham SV.
The Journal of general virology. 2020 Mar;().
The infectious life cycle of human papillomaviruses (HPVs) is tightly linked to keratinocyte differentiation. Evidence suggests a sophisticated interplay between host gene regulation and virus replication. Alternative splicing is an essential process for host and viral gene expression, and is genera
PMID 32182205

pSpatiocyte: a high-performance simulator for intracellular reaction-diffusion systems.

Arjunan SNV, Miyauchi A, Iwamoto K, Takahashi K.
BMC bioinformatics. 2020 Jan;21(1)33.
Studies using quantitative experimental methods have shown that intracellular spatial distribution of molecules plays a central role in many cellular systems. Spatially resolved computer simulations can integrate quantitative data from these experiments to construct physically accurate models of the
PMID 31996129

Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans.

Geßele R, Halatek J, Würthner L, Frey E.
Nature communications. 2020 Jan;11(1)539.
In the Caenorhabditis elegans zygote, PAR protein patterns, driven by mutual anatagonism, determine the anterior-posterior axis and facilitate the redistribution of proteins for the first cell division. Yet, the factors that determine the selection of the polarity axis remain unclear. We present a r
PMID 31988277

Japanese Journal

GDP-Bound Rab27a Dissociates from the Endocytic Machinery in a Phosphorylation-Dependent Manner after Insulin Secretion

Kimura Toshihide,Yamaoka Mami,Terabayashi Takeshi,Kaibuchi Kozo,Ishikawa Tomohisa,Ishizaki Toshimasa
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 42(9), 1532-1537, 2019
… Phosphorylation of IQGAP1 on serine (Ser)-1443, a site recognized by protein kinase Cε (PKCε), inhibited the interaction of GDP-bound Rab27a with IQGAP1 in a Cdc42-independent manner. … However, the expression of the non-phosphorylatable or phosphomimetic form of IQGAP1 could not rescue the inhibition, suggesting that a phosphorylation-dephosphorylation cycle of IQGAP1 is required for endocytosis. …
NAID 130007700076

Plk1 Phosphorylates CLIP-170 and Regulates Its Binding to Microtubules for Chromosome Alignment

Kakeno Mai,Matsuzawa Kenji,Matsui Toshinori [他],Watanabe Takashi,Matsuzawa Kenji,Matsui Toshinori,Akita Hiroki,Sugiyama Ikuko,Ishidate Fumiyoshi,Nakano Atsushi,Takashima Seiji,Goto Hidemasa
Cell Structure and Function 39(1), 45-59, 2014
… Here, we show that phosphorylation at Ser312 in the third serine-rich region of CLIP-170 is increased during mitosis. … Polo-like kinase 1 (Plk1) is responsible for this phosphorylation during the mitotic phase of dividing cells. … analysis using a purified CLIP-170 N-terminal fragment showed that phosphorylation by Plk1 diminishes CLIP-170 binding to the MT ends and lattice without affecting binding to EB3. …
NAID 130004053900

シアノバクテリア時計タンパク質KaiCの生化学的解析による概日時計の分子機構

寺内一姫,西脇妙子,北山陽子,近藤孝男
日本植物生理学会年会およびシンポジウム　講演要旨集 2008(0), 0583-0583, 2008
シアノバクテリアは概日時計をもつ最も単純な生物であり、その概日時計は真核生物と同じ基本性質を保持している。最近、我々はシアノバクテリアの3つの時計タンパク質KaiA、KaiB、KaiCとATPにより、概日時計再構成系の構築に成功した。これは時間を測定するメカニズムがタンパク質の生化学的性質により説明可能であることを意味している。再構成系においてKaiC の非常に低いATPase活性が24時間周期で …
NAID 130006993992