phosphoglycolic acid

WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

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When DNA repair goes wrong: BER-generated DNA-protein crosslinks to oxidative lesions.

Quiñones JL1, Demple B2.
DNA repair.DNA Repair (Amst).2016 Aug;44:103-9. doi: 10.1016/j.dnarep.2016.05.014. Epub 2016 May 20.
Free radicals generate an array of DNA lesions affecting all parts of the molecule. The damage to deoxyribose receives less attention than base damage, even though the former accounts for ∼20% of the total. Oxidative deoxyribose fragments (e.g., 3'-phosphoglycolate esters) are removed by the Ape1
PMID 27264558

A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast.

Collard F1,2, Baldin F1,2, Gerin I1,2, Bolsée J1,2, Noël G1,2, Graff J1,2, Veiga-da-Cunha M1,2, Stroobant V3, Vertommen D4, Houddane A4, Rider MH4, Linster CL5, Van Schaftingen E1,2, Bommer GT1,2.
Nature chemical biology.Nat Chem Biol.2016 Aug;12(8):601-7. doi: 10.1038/nchembio.2104. Epub 2016 Jun 13.
Metabolic enzymes are very specific. However, most of them show weak side activities toward compounds that are structurally related to their physiological substrates, thereby producing side products that may be toxic. In some cases, 'metabolite repair enzymes' eliminating side products have been ide
PMID 27294321

Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase.

Richard JP1, Amyes TL1, Malabanan MM1, Zhai X1, Kim KJ1, Reinhardt CJ1, Wierenga RK2, Drake EJ3,4, Gulick AM3,4.
Biochemistry.Biochemistry.2016 May 31;55(21):3036-47. doi: 10.1021/acs.biochem.6b00311. Epub 2016 May 17.
Kinetic parameters are reported for the reactions of whole substrates (kcat/Km, M(-1) s(-1)) (R)-glyceraldehyde 3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP) and for the substrate pieces [(kcat/Km)E·HPi/Kd, M(-2) s(-1)] glycolaldehyde (GA) and phosphite dianion (HPi) catalyzed by the I172
PMID 27149328