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1. 男性性機能不全の治療 treatment of male sexual dysfunction
2. 成人における肺高血圧症の治療 treatment of pulmonary hypertension in adults
3. 収縮能障害による心不全における強心剤 inotropic agents in heart failure due to systolic dysfunction
4. 心不全患者において使用をさけるべき、または慎重に使用するべき薬 drugs that should be avoided or used with caution in patients with heart failure
5. 安定した慢性閉塞性肺疾患の管理 management of stable chronic obstructive pulmonary disease

English Journal

Phosphodiesterase 7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis.

Mestre L1, Redondo M2, Carrillo-Salinas FJ1, Morales-García JA3,4, Alonso-Gil S3,4, Pérez-Castillo A3,4, Gil C5, Martínez A5, Guaza C1.
British journal of pharmacology.Br J Pharmacol.2015 May 21. doi: 10.1111/bph.13192. [Epub ahead of print]
BACKGROUND AND PURPOSE: cyclic Adenosine monophosphate (cAMP) plays an important role in the transduction of signaling pathways involved in neuroprotection and immune regulation. Control of the levels of this nucleotide by inhibition of cAMP specific phosphodiesterases (PDEs) such as PDE7 may affect
PMID 25994655

2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy.

Endo Y1, Kawai K2, Asano T2, Amano S2, Asanuma Y2, Sawada K2, Onodera Y2, Ueo N2, Takahashi N2, Sonoda Y2, Kamei N2, Irie T3.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 May 1;25(9):1910-4. doi: 10.1016/j.bmcl.2015.03.031. Epub 2015 Mar 20.
A new series of thienopyrimidinones is synthesized and evaluated as selective phosphodiesterase 7 (PDE7) inhibitors for the treatment of inflammatory diseases. The modification of the substituents on thienopyrimidinone revealed that an isopropylamino group at the 2-position was favorable for aqueous
PMID 25866242

Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats.

Morales-Garcia JA1, Alonso-Gil S1, Gil C1, Martinez A1, Santos A1, Perez-Castillo A2.
Stem cells translational medicine.Stem Cells Transl Med.2015 Apr 29. pii: sctm.2014-0277. [Epub ahead of print]
Parkinson's disease is characterized by a loss of dopaminergic neurons in a specific brain region, the ventral midbrain. Parkinson's disease is diagnosed when approximately 50% of the dopaminergic neurons of the substantia nigra pars compacta (SNpc) have degenerated and the others are already affect
PMID 25925836

Effect of olprinone on liver microstructure in rat partial liver transplantation.

Yamanaka Kenya,Hatano Etsuro,Iguchi Khota,Yamamoto Gen,Sato Motohiko,Toriguchi Kan,Tanabe Kazutaka,Takemoto Kenji,Nakamura Kojiro,Koyama Noriyuki,Narita Masato,Nagata Hiromitsu,Taura Kojiro,Uemoto Shinji
The Journal of surgical research 183(1), 391-396, 2013-07-00
… In a previous study, we showed that olprinone (OLP), a selective phosphodiesterase ІІІ inhibitor, up-regulates endothelial nitric oxide synthase level in the liver and attenuates shear stress, sinusoidal endothelial cell injury, and hepatocyte apoptosis after excessive liver resection in a rat model. …
NAID 120005298136

Horai Shoji,Nakagawa Shinsuke,Tanaka Kunihiko,Morofuji Yoichi,Couraud Pierre-Oliver,Deli Maria A.,Ozawa Hiroki,Niwa Masami
Cellular and Molecular Neurobiology 33(2), 291-307, 2013-03-00
… We studied the effect of cilostazol, a selective inhibitor of phosphodiesterase 3, on barrier functions of blood-brain barrier (BBB)-related endothelial cells, primary rat brain capillary endothelial cells (RBEC), and the immortalized human brain endothelial cell line hCMEC/D3. … There was expression of phosphodiesterase 3B mRNA in RBEC, and a significant increase in intracellular cyclic AMP (cAMP) content was detected in RBEC treated with both 1 and 10 μM cilostazol. …
NAID 120005303621

Effect of Tadalafil on Neointimal Hyperplasia in a Rabbit Carotid Artery Anastomosis Model

Guzeloglu Mehmet,Aykut Koray,Albayrak Gokhan,Atmaca Soner,Oktar Suleyman,Bagriyanik Alper,Hazan Eyup
Annals of Thoracic and Cardiovascular Surgery, 2013
… Phosphodiesterase V is detected in the peripheral coronary and pulmonary vascular smooth muscle cells and in the cardiac tissue. … Based on the effects of phosphodiesterase V inhibitors on vascular smooth muscle cells, in the present study, the effect of tadalafi l, a new member of phosphodiesterase V inhibitors, on neointimal hyperplasia was investigated in the rabbit carotid artery anastomosis model. …
NAID 130003377813