- 関
- CDPdiacylglycerol-serine O-phosphatidyltransferase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/12/29 00:47:30」(JST)
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| CDP-diacylglycerol-serine O-phosphatidyltransferase |
| Identifiers |
| EC number |
2.7.8.8 |
| CAS number |
9068-48-8 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / QuickGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase (EC 2.7.8.8) is an enzyme that catalyzes the chemical reaction
- CDP-diacylglycerol + L-serine CMP + (3-sn-phosphatidyl)-L-serine
Thus, the two substrates of this enzyme are CDP-diacylglycerol and L-serine, whereas its two products are CMP and (3-sn-phosphatidyl)-L-serine.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:L-serine 3-sn-phosphatidyltransferase. Other names in common use include phosphatidylserine synthase, CDPdiglyceride-serine O-phosphatidyltransferase, PS synthase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol, (CDPdiglyceride):L-serine O-phosphatidyltransferase, phosphatidylserine synthetase, CDP-diacylglycerol-L-serine O-phosphatidyltransferase, cytidine diphosphoglyceride-serine O-phosphatidyltransferase, CDP-diglyceride-L-serine phosphatidyltransferase, CDP-diglyceride:serine phosphatidyltransferase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine, O-phosphatidyltransferase, and CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.
References
- Larson TJ, Dowhan W (1976). "Ribosomal-associated phosphatidylserine synthetase from Escherichia coli: purification by substrate-specific elution from phosphocellulose using cytidine 5'-diphospho-1,2-diacyl-sn-glycerol". Biochemistry. 15 (24): 5212–8. doi:10.1021/bi00669a003. PMID 187212.
- Raetz CR, Kennedy EP (1974). "Partial purification and properties of phosphatidylserine synthetase from Escherichia coli". J. Biol. Chem. 249 (16): 5083–45. PMID 4604873.
|
Transferases: phosphorus-containing groups (EC 2.7)
|
2.7.1-2.7.4:
phosphotransferase/kinase
(PO4) |
| 2.7.1: OH acceptor |
- Hexo-
- Gluco-
- Fructo-
- Galacto-
- Phosphofructo-
- 1
- Liver
- Muscle
- Platelet
- 2
- Riboflavin
- Shikimate
- Thymidine
- NAD+
- Glycerol
- Pantothenate
- Mevalonate
- Pyruvate
- Deoxycytidine
- PFP
- Diacylglycerol
- Phosphoinositide 3
- Class I PI 3
- Class II PI 3
- Sphingosine
- Glucose-1,6-bisphosphate synthase
|
| 2.7.2: COOH acceptor |
- Phosphoglycerate
- Aspartate kinase
|
| 2.7.3: N acceptor |
|
| 2.7.4: PO4 acceptor |
- Phosphomevalonate
- Adenylate
- Nucleoside-diphosphate
- Uridylate
- Guanylate
- Thiamine-diphosphate
|
|
2.7.6: diphosphotransferase
(P2O7) |
- Ribose-phosphate diphosphokinase
- Thiamine diphosphokinase
|
2.7.7: nucleotidyltransferase
(PO4-nucleoside) |
| Polymerase |
| DNA polymerase |
- DNA-directed DNA polymerase
- I
- II
- III
- IV
- V
- RNA-directed DNA polymerase
- Reverse transcriptase
- Telomerase
- DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
|
| RNA nucleotidyltransferase |
- RNA polymerase/DNA-directed RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA polymerase IV
- Primase
- RNA-dependent RNA polymerase
- PNPase
|
|
Phosphorolytic
3' to 5' exoribonuclease |
|
| Nucleotidyltransferase |
- UTP—glucose-1-phosphate uridylyltransferase
- Galactose-1-phosphate uridylyltransferase
|
| Guanylyltransferase |
|
| Other |
- Recombinase (Integrase)
- Transposase
|
|
| 2.7.8: miscellaneous |
| Phosphatidyltransferases |
- CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
- CDP-diacylglycerol—serine O-phosphatidyltransferase
- CDP-diacylglycerol—inositol 3-phosphatidyltransferase
- CDP-diacylglycerol—choline O-phosphatidyltransferase
|
| Glycosyl-1-phosphotransferase |
- N-acetylglucosamine-1-phosphate transferase
|
|
2.7.10-2.7.13: protein kinase
(PO4; protein acceptor) |
| 2.7.10: protein-tyrosine |
|
| 2.7.11: protein-serine/threonine |
- see serine/threonine-specific protein kinases
|
| 2.7.12: protein-dual-specificity |
- see serine/threonine-specific protein kinases
|
| 2.7.13: protein-histidine |
- Protein-histidine pros-kinase
- Protein-histidine tele-kinase
- Histidine kinase
|
|
|
Enzymes
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
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English Journal
- Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis.
- von Wnuck Lipinski K1, Weske S1, Keul P1, Peters S1, Baba HA2, Heusch G1, Gräler MH3,4, Levkau B1.
- Blood.Blood.2017 Dec 21;130(25):2786-2798. doi: 10.1182/blood-2017-03-774356. Epub 2017 Nov 6.
- PMID 29109103
- Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae.
- Miyata N1, Goda N1, Matsuo K1, Hoketsu T1, Kuge O2.
- Scientific reports.Sci Rep.2017 Nov 27;7(1):16447. doi: 10.1038/s41598-017-16661-2.
- PMID 29180659
- Phosphatidylserine decarboxylase CT699, lysophospholipid acyltransferase CT775, and acyl-ACP synthase CT776 provide membrane lipid diversity to Chlamydia trachomatis.
- Soupene E1, Kuypers FA2.
- Scientific reports.Sci Rep.2017 Nov 17;7(1):15767. doi: 10.1038/s41598-017-16116-8.
- PMID 29150677
Japanese Journal
- Inositol Depletion Restores Vesicle Transport in Yeast Phospholipid Flippase Mutants
- P3-4-1 SyncytiotrophoblastにおけるPhosphatidylserine synthase-1/synthase-2の発現について(Group 101 妊娠高血圧症候群4,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
Related Links
- 5 Sep 2012 ... Protein names, Recommended name: Phosphatidylserine synthase 1. Short name= PSS-1. Short name= PtdSer synthase 1. EC= 2.7.8.29. Alternative name(s ): Serine-exchange enzyme I. Gene names ...
★リンクテーブル★
[★]
- 英
- phosphatidylserine synthase
- 関
- CDPジアシルグリセロール・セリン-O-ホスファチジルトランスフェラーゼ、ホスファチジルセリン合成酵素
[★]
CDPジアシルグリセロール・セリン-O-ホスファチジルトランスフェラーゼ
- 関
- phosphatidylserine synthase
[★]
- 英
- phosphatidylserine synthase
- 関
- ホスファチジルセリンシンターゼ
[★]
- 関
- lyase、synthetase、transferase
[★]
ホスファチジルセリン