phosphatidylcholine-sterol O-acyltransferase

ホスファチジルコリン・ステロール-O-アシル転移酵素、ホスファチジルコリン・ステロール-O-アシルトランスフェラーゼ

関

lecithin acyltransferase、lecithin cholesterol acyltransferase

WordNet

1. the 15th letter of the Roman alphabet (同)o
2. the blood group whose red cells carry neither the A nor B antigens; "people with type O blood are universal donors" (同)type_O, group O
3. any of a group of natural steroid alcohols derived from plants or animals; they are waxy insoluble substances (同)steroid alcohol

PrepTutorEJDIC

1. 《呼び掛けの名前の前につけて》『おお』,あ / (驚き・恐れ・喜び・苦痛などを表して)『おお』,ああ,まあ / 《肯定・否定を強めて》
2. oxygenの化学記号
3. ohmオーム / Old
4. osmiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/19 22:03:50」(JST)

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[Wiki en表示]

phosphatidylcholine-sterol O-acyltransferase
Identifiers
EC number	2.3.1.43
CAS number	9031-14-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a phosphatidylcholine---sterol O-acyltransferase (EC 2.3.1.43) is an enzyme that catalyzes the chemical reaction

phosphatidylcholine + a sterol 1-acylglycerophosphocholine + a sterol ester

Thus, the two substrates of this enzyme are phosphatidylcholine and sterol, whereas its two products are 1-acylglycerophosphocholine and sterol ester.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phosphatidylcholine:sterol O-acyltransferase. Other names in common use include lecithin---cholesterol acyltransferase, phospholipid---cholesterol acyltransferase, LCAT (lecithin-cholesterol acyltransferase), lecithin:cholesterol acyltransferase, and lysolecithin acyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

• Bartlett K, Keat MJ and Mercer EI (1974). "Biosynthesis of sterol esters in Phycomyces blakesleeanus". Phytochemistry 13: 1107–1113. doi:10.1016/0031-9422(74)80083-X. 
• Buckley JT, Halasa LN, MacIntyre S (1982). "Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase". J. Biol. Chem. 257 (6): 3320–5. PMID 7061477. 
• Glomset JA (1968). "The plasma lecithins:cholesterol acyltransferase reaction". J. Lipid. Res. 9 (2): 155–67. PMID 4868699. 
• Vahouny GV, Treadwell CR (1968). "Enzymatic synthesis and hydrolysis of cholesterol esters". Methods. Biochem. Anal. 16: 219–72. doi:10.1002/9780470110348.ch4. PMID 4877146. 

UpToDate Contents

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English Journal

• The Effect of Natural LCAT Mutations on the Biogenesis of HDL.

• Fotakis P1,2, Kuivenhoven JA3, Dafnis E4, Kardassis D2, Zannis VI1.
• Biochemistry.Biochemistry.2015 Jun 2;54(21):3348-59. doi: 10.1021/acs.biochem.5b00180. Epub 2015 May 22.
• We have investigated how the natural LCAT[T147I] and LCAT[P274S] mutations affect the pathway of biogenesis of HDL. Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.2- and 2.9-fold increase, respectively
• PMID 25948084

• Acquired lecithin:cholesterol acyltransferase deficiency as a major factor in lowering plasma HDL levels in chronic kidney disease.

• Calabresi L1, Simonelli S, Conca P, Busnach G, Cabibbe M, Gesualdo L, Gigante M, Penco S, Veglia F, Franceschini G.
• Journal of internal medicine.J Intern Med.2015 May;277(5):552-61. doi: 10.1111/joim.12290. Epub 2014 Aug 1.
• OBJECTIVES: It has been suggested that a low plasma high-density lipoprotein cholesterol (HDL-C) level contributes to the high cardiovascular disease risk of patients with chronic kidney disease (CKD), especially those undergoing haemodialysis (HD). The present study was conducted to gain further un
• PMID 25039266

• Mouse models of disturbed HDL metabolism.

• Hoekstra M1, Van Eck M.
• Handbook of experimental pharmacology.Handb Exp Pharmacol.2015;224:301-36. doi: 10.1007/978-3-319-09665-0_9.
• High-density lipoprotein (HDL) is considered to be an anti-atherogenic lipoprotein moiety. Generation of genetically modified (total body and tissue-specific knockout) mouse models has significantly contributed to our understanding of HDL function. Here we will review data from knockout mouse studie
• PMID 25522993

Related Links

• Phosphatidylcholine-sterol o-acyltransferase - definition of ...

Definition of Phosphatidylcholine-sterol o-acyltransferase in the Medical Dictionary. Phosphatidylcholine-sterol o-acyltransferase explanation. Information about Phosphatidylcholine-sterol o-acyltransferase in Free online English ...

• Phosphatidylcholine-sterol O-acyltransferase - Springer

EC number 2.3.1.43 Systematic name phosphatidylcholine:sterol O-acyltransferase Recommended name phospha ... Download Book (3,770 KB) As a courtesy to our readers the eBook is provided DRM-free. However ...

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「lecithin acyltransferase」

　　[★]

レシチンアシル基転移酵素、レシチンアシルトランスフェラーゼ

関

lecithin cholesterol acyltransferase、phosphatidylcholine-sterol O-acyltransferase

「ホスファチジルコリン・ステロール-O-アシルトランスフェラーゼ」

　　[★]

英

phosphatidylcholine-sterol O-acyltransferase

関

レシチンアシルトランスフェラーゼ、ホスファチジルコリン・ステロール-O-アシル転移酵素

「ホスファチジルコリン・ステロール-O-アシル転移酵素」

　　[★]

英

phosphatidylcholine-sterol O-acyltransferase

関

ホスファチジルコリン・ステロール-O-アシルトランスフェラーゼ

「acyltransferase」

　　[★]

アシルトランスフェラーゼ、アシル転移酵素、アシル基転移酵素

関

transacylase

「O」

　　[★]

同

食道入口部

　 　 　 　 　

「Os」

　　[★] オスミウム osmium 　

「phosphatidylcholine」

　　[★] ホスファチジルコリン