WordNet

the branch of genetics that studies the genetically determined variations in responses to drugs in humans or laboratory organisms

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The impact of pharmacogenetics on radiation therapy outcome in cancer patients. A focus on DNA damage response genes.

Borchiellini D, Etienne-Grimaldi MC, Thariat J, Milano G.SourceOncopharmacology Unit, Centre Antoine Lacassagne, 33 avenue Valombrose, 06100 Nice, France. delphinebor@wanadoo.fr
Cancer treatment reviews.Cancer Treat Rev.2012 Oct;38(6):737-59. Epub 2012 Mar 2.
More than half of cancer patients are treated by radiation therapy, with a wide inter-patient variability in tumour response. Recent advances have been made in understanding molecular mechanisms that govern the behaviour of tumour cells and tissues exposed to ionizing radiation. Accumulating data su
PMID 22387145

MacPhee IA.SourceDivision of Clinical Sciences: Renal Medicine, St. George's, University of London, London, UK. imacphee@sgul.ac.uk
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2012 Sep 8;413(17-18):1312-7. Epub 2011 Oct 18.
The immunosuppressive drugs used for solid organ transplantation all have a narrow therapeutic index with wide variation between individuals in the blood concentration achieved by a given dose. Therapeutic drug monitoring is employed routinely but may not allow optimisation of drug exposure during t
PMID 22037511

ReninAngiotensin System, Hypertension, and Chronic Kidney Disease : Pharmacogenetic Implications

谷口敦夫
東京女子医科大学雑誌 81(3), 198-203, 2011-06-25
全ゲノム関連解析が行われるようになり、多因子疾患の遺伝子解析が急速に進んでいる。多くのcommon diseaseは多因子疾患であり、遺伝子解析は病態解明や重症化・合併症の予測に役立つものと考えられる。また、薬理遺伝学的な解析も治療の進歩に寄与するであろう。本稿では、リウマチ性疾患のなかで最も遺伝子解析が進んでいる関節リウマチ(rheumatoid arthritis、RA)を取りあげ、発症、合併 …
NAID 110008585264