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The structure of the technetate(VII) ion.

The pertechnetate (technetate(VII)) ion is an oxoanion with the chemical formula TcO₄⁻. It is often used as a convenient water-soluble source of isotopes of the radioactive element technetium (Tc). In particular it is used to carry the Tc-99m isotope (half-life 6 hours) which is commonly used in nuclear medicine in several nuclear scanning procedures.

A technetate(VII) is a compound containing this ion. Pertechnetates are salts of technetic(VII) acid. Pertechnetate is analogous to permanganate but it has little oxidizing power.

Use of pertechnetate to carry technetium-99m

A technetium-99m generator provides the pertechnetate containing the short-lived isotope Tc-99m for medical uses. This compound is generated directly from molybdate held on alumina within the generator (see this topic for detail).

Uses in nuclear medicine

Pertechnetate has a wide variety of uses in diagnostic nuclear medicine. Since technetate(VII) can substitute for iodine in the Na/I Symporter (NIS) Channel in follicular cells of the thyroid gland, inhibiting uptake of iodine into the follicular cells, Tc^99m-pertechnetate can be used as an alternative to I¹²³ in imaging of the thyroid, although it specifically measures uptake and not organification.^[1] It has also been used historically to evaluate for testicular torsion, although ultrasound is more commonly used in current practice, as it does not deliver a radiation dose to the testes. It is also used in labeling of autologus red blood cells for MUGA scans to evaluate left ventricular cardiac function, localization of gastrointestinal bleeding prior to embolization or surgical management, and in damaged red blood cells to detect ectopic splenic tissue.

It is actively accumulated and secreted by the mucoid cells of the gastric mucosa,^[2] and therefore, technetate(VII) radiolabeled with Tc99m is injected into the body when looking for ectopic gastric tissue as is found in a Meckel's diverticulum with Meckel's Scans.^[3]

Uses of pertechnetate which do not rely on its radioactivity

All technetium salts are mildy radioactive, but some of them have explored use of the element for its chemical properties. In these uses, its radioactivity is incidental, and generally the least radioactive (longest lived) isotopes of Tc are used. In particular, Tc-99 (half-life 211,000 years) is used in corrosion research, because it is the decay product of the easily obtained commercial Tc-99m isotope^{[citation needed]}, which is its nuclear isomer. In theory, the longest-lived technetium isotope, Tc-97 (half-life 2.6 million years), would be the optimal isotope for this use.

Solutions of technetate(VII) react with the surface of iron to form technetium dioxide, in this way it is able to act as an anodic corrosion inhibitor.

References

^ Ryo, U.Y.; Vaidya, P.V.; Schneider, A.B.; Bekerman, C; Pinsky, S.M. (1983). "Thyroid imaging agents: a comparison of I-123 and Tc-99m pertechnetate". Radiology 148 (3): 819–822. PMID 6308711.
^ Nuclear Imaging of Meckel's Diverticulum: A Pictorial Essay of Pitfalls S. Huynh, M.D., R. Amin, M.D., B. Barron, M.D., R. Dhekne, M.D., P. Nikolaidis, M.D., L. Lamki, M.D.. University of Texas Houston Medical School and Memorial Hermann - Texas Medical Center (TMC), St. Luke's Episcopal Hospital and Texas Children Hospital, Houston, Texas. Last Modified September 5, 2007
^ Diamond, Robert; Rothstein, Robin; Alavi, Abass (1991). "The Role of Cimetidine-Enhanced Technetium 99m-Pertechnetate Imaging for Visualizing Meckel's Diverticulum" (PDF). The Journal of Nuclear Medicine 32 (7): 1422–1424.

UpToDate Contents

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1. メッケル憩室 meckels diverticulum
2. 甲状腺結節の診断的アプローチおよび治療 diagnostic approach to and treatment of thyroid nodules
3. Evaluation of suspected small bowel bleeding (formerly obscure gastrointestinal bleeding)
4. 肝血管腫 hepatic hemangioma
5. 成人における急性下部消化管出血に対するアプローチ approach to acute lower gastrointestinal bleeding in adults

English Journal

Imaging identifies submandibular ectopic thyroid tissue.

Rosa Pelizzo M, Torresan F, Grassetto G, Briani G, Cristina Marzola M, Rubello D.SourceFrom the *Department of Special Surgical Pathology, University of Padova, Padova, Italy; †Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy; and ‡Department of Pathology, San Dona di Piave Hospital, Venezia, Italy.
Clinical nuclear medicine.Clin Nucl Med.2011 Aug;36(8):728-30.
The identification of submandibular ectopic normal thyroid in the lateral neck with a coexisting normally located and functional thyroid gland is rare. Ectopic normal thyroid tissue in the midline location is most commonly related to aberrant migration along the thyroglossal duct (ie, lingual thyroi
PMID 21716035

Unilateral Agenesis of the Parotid Gland With Contralateral Compensation Hypermetabolism of FDG.

Chen YK, Kuo CJ, Yeh CL.SourceFrom the *Department of Nuclear Medicine and PET Center, Shin Kong Wu Ho-Su Memorial Hospital, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan; and †Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
Clinical nuclear medicine.Clin Nucl Med.2011 Aug;36(8):710-1.
A 75-year-old man with prostate adenocarcinoma had a baseline FDG PET/CT that demonstrated increased left parotid and absent right parotid activity. The CT revealed fat in the right parotid space and enlargement of the left parotid gland. There was no history of dry mouth. Agenesis of one or more of
PMID 21716029

Japanese Journal

ダブルバルーン小腸内視鏡にて診断し得た小児メッケル憩室の2 症例

薄井佳子,前田貢作,小野滋,栁澤智彦,馬場勝尚,辻由貴
日本小児外科学会雑誌 50(2), 223-225, 2014
小児メッケル憩室の診断にダブルバルーン小腸内視鏡（double-balloon enteroscopy: DBE）が有用であった2 症例を経験したので報告する．症例1 は8 歳男児．心疾患を背景とした慢性貧血の経過中，倦怠感と黒色便が出現してヘモグロビン値が4.5 g/dl まで低下した．出血シンチグラフィ陽性で，上・下部内視鏡検査を施行されたが出血源不明であり，当院紹介となった．症例2 は12 …
NAID 130004897699

ワルチン腫瘍の診断における酸負荷唾液腺シンチグラフィの集積とMRI 所見や病理組織所見との比較

神宮司メグミ,田邉博昭,中條政敬,中別府良昭,福倉良彦,松根彰志,義岡孝子,ジングウジメグミ,タナベヒロアキ,ナカジョウマサタカ,ナカベップヨシアキ,フククラヨシヒコ,マツネショウジ,ヨシオカタカコ,JINGUJI Megumi,TANABE Hiroaki,NAKAJO Masataka,NAKABEPPU Yoshiaki,FUKUKURA Yoshihiko,MATSUNE Shoji,YOSHIOKA Takako
鹿児島大学医学雑誌=Medical journal of Kagoshima University 65(1), 9-18, 2013-05-10
… Purpose: To examine the relationships between degrees of 99mTc pertechnetate (99mTcO4−) uptake after acid stimulationand the tumor size as well as histopathological subtypes of Warthin tumor and to evaluate the diagnostic accuracy of99mTcO4− scintigraphy and routine magnetic resonance (MR) imaging in differentiating Warthin and non-Warthin tumors ofthe parotid gland. …
NAID 120005447096

⁹⁹[m]Tc Pertechnetate Scintigraphy for Warthin Tumors of the Parotid Gland : Comparison of Histopathological and Magnetic Resonance Imaging findings

神宮司メグミ,田邉博昭,中條政敬 [他]
鹿児島大学医学雑誌 65(1), 9-18, 2013-05
NAID 40019763292

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