WordNet

(chemistry) a process in which one substance permeates another; a fluid permeates or is dissolved by a liquid or solid (同)soaking up
(physics) the process in which incident radiated energy is retained without reflection or transmission on passing through a medium; "the absorption of photons by atoms or molecules"

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吸収,併合 / (…に)夢中になること,専心すること《+『in』+『名』》

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1. ST上昇型心筋梗塞に対する血栓溶解後の経皮的冠動脈インターベンション percutaneous coronary intervention after fibrinolysis for acute st elevation myocardial infarction
2. 急性ST上昇型心筋梗塞における緊急経皮的冠動脈インターベンション（Primary
PCI）：周術期マネージメント primary percutaneous coronary intervention in acute st elevation myocardial infarction periprocedural management
3. 経皮的冠動脈形成術の周術期合併症 periprocedural complications of percutaneous coronary intervention
4. ST上昇型心筋梗塞におけるプライマリ経皮的冠動脈インターベンション：転帰の
決定因子 primary percutaneous coronary intervention in acute st elevation myocardial infarction determinants of outcome
5. 経皮的気管穿刺換気法による針輪状甲状軟骨間膜切開 needle cricothyroidotomy with percutaneous transtracheal ventilation

English Journal

Iatrogenic Cushing's syndrome and topical steroid therapy: case series and review of the literature.

Decani S1, Federighi V, Baruzzi E, Sardella A, Lodi G.Author information 1Dipartimento di scienze biomediche, chirurgiche e odontoiatriche, Università degli Studi di Milano , Milano , Italy.AbstractTopical corticosteroids are considered first-line therapy in patients with chronic inflammatory oral mucosal diseases; among them, clobetasol propionate is one of the most widely used in oral medicine. Under physiological conditions, the transmucosal application is characterized by a significantly greater absorption than the skin application. Contrary to many publications about the side effects of topical corticosteroids in dermatology, few studies have investigated the systemic effects due to local application of these drugs on oral mucosa. Although topical steroid therapy for the management of oral diseases is generally associated with local adverse effects (candidiasis, stomatopyrosis, and hypogeusia), these drugs can also lead to systemic side effects, such as suppression of the hypothalamic-pituitary-adrenal axis and Cushing's syndrome. This review reports five cases of systemic adverse effects caused by clobetasol propionate topical treatment.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):495-500. doi: 10.3109/09546634.2012.755252. Epub 2013 Feb 3.
Topical corticosteroids are considered first-line therapy in patients with chronic inflammatory oral mucosal diseases; among them, clobetasol propionate is one of the most widely used in oral medicine. Under physiological conditions, the transmucosal application is characterized by a significantly g
PMID 23210698

Preparation and characterisation of peanut seed skin polyphenols.

Tsujita T1, Shintani T2, Sato H3.Author information 1Bioscience, Integrated Center for Sciences, Ehime University, Shitsukawa, Toon, Ehime, Japan. Electronic address: tsujita@m.ehime-u.ac.jp.2Ehime Institute of Industrial Technology, 2-5-48 Higashimura-minami, Imabari, Ehime, Japan.3Research Institute for Environmental Management Technology, National Institute of Advanced Industrial Science and Technology (AIST), 16-1 Onogawa, Tsukuba, Ibaraki, Japan.AbstractUsing α-amylase inhibition as a separation guide, polyphenolic compounds from peanut seed skin were prepared. During preparation, specific α-amylase inhibitory activities were increased about 4-fold. High-resolution MALDI-TOF mass spectra showed that the structure of this sample was a series of polyflavan-3-ols, up to 15-mer, composed of catechin/epicatechin units together with several afzelechin/epiafzelechin units and gallocatechin/epigallocatechin units. The observed precious mass values suggest that the polymers consist of both interflavanoid C-C linkages (A-type) and interflavanoid ether linkages (B-type). Oral administration of the polyphenol fraction to rats fed corn starch significantly suppressed an increase in blood glucose levels in a dose dependent manner. Administration of the polyphenol fraction to rats fed maltose or sucrose delayed the increase in blood glucose levels. These results suggest peanut seed skin contains polyphenols with strong α-amylase inhibitory activity, which retard absorption of carbohydrates and mainly function through inhibition of α-amylase.
Food chemistry.Food Chem.2014 May 15;151:15-20. doi: 10.1016/j.foodchem.2013.11.072. Epub 2013 Nov 20.
Using α-amylase inhibition as a separation guide, polyphenolic compounds from peanut seed skin were prepared. During preparation, specific α-amylase inhibitory activities were increased about 4-fold. High-resolution MALDI-TOF mass spectra showed that the structure of this sample was a series of po
PMID 24423496

The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine.

Ookubo N1, Michiue H2, Kitamatsu M3, Kamamura M1, Nishiki T1, Ohmori I1, Matsui H1.Author information 1Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-Ku, Okayama 700-8558, Japan.2Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-Ku, Okayama 700-8558, Japan. Electronic address: hmichiue@md.okayama-u.ac.jp.3Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.AbstractTopical therapy is the most favored form of treatment for whitening against hyper-pigmentation and sunburn because it lends itself to self-administration, patient compliance and an absence of systemic adverse effects. However, high-molecular-weight, hydrophilic chemicals are difficult to use as transdermal delivery drugs and the use of topical drugs has been highly limited. There are now many potent tyrosinase inhibitors, for example, sulfite or kojic acid, but the efficacy of their skin transduction remains a big problem. Furthermore, melanogenesis inhibitors from natural sources have great potential, as they are considered to be safe and largely free from adverse side effects. We applied 11-arginine (11R), a cell-membrane-permeable peptide, as a transdermal delivery system with a skin delivery enhancer, pyrenbutyrate. We performed intracellular screening for melanogenesis inhibitors with 11R fused with several kinds of tyrosinase inhibitory peptides from natural sources. Of 28 tyrosinase peptides, 13 melanin synthesis inhibitory peptides were selected. Peptide No. 10 found in gliadin protein, a wheat component, most strongly inhibited melanin production. This No. 10 peptide, of only 8 amino acids, fused to 11R showed no cytotoxicity and inhibited melanin synthesis as determined through melanin content measured using an absorption spectrometer and observation with a transmission electron microscope. Next, we transduced this 11R-No. 10 into skin with an 11R transdermal delivery system after previous treatment with pyrenbutyrate and performed daily repetitive topical application for two weeks against a UV-induced sun-tanning guinea pig model. We observed a whitening effect in a model skin sample by Masson-Fontana staining and the 11R-No. 10 peptide-applied area showed significant melanogenesis inhibition. These results show that 11R using a transdermal drug delivery system with melanogenesis inhibitory peptide is a very safe and promising method for applications from cosmetics to the pharmaceutical industry.
Biomaterials.Biomaterials.2014 May;35(15):4508-16. doi: 10.1016/j.biomaterials.2014.01.052. Epub 2014 Mar 3.
Topical therapy is the most favored form of treatment for whitening against hyper-pigmentation and sunburn because it lends itself to self-administration, patient compliance and an absence of systemic adverse effects. However, high-molecular-weight, hydrophilic chemicals are difficult to use as tran
PMID 24602570

Japanese Journal

炭酸ガスの化粧品への配合と肌質改善効果に関して (特集炭酸ガスの効果と香粧品への応用)

角本次郎
Fragrance journal = フレグランスジャーナル 43(7), 40-44, 2015-07
NAID 40020540213

難・低吸収性薬物のマイクロニードル皮内投与DDS製剤の開発 (特集マイクロニードルを応用した製剤開発と経皮吸収)

高田寛治
Fragrance journal 43(1), 56-62, 2015-01
NAID 40020326709

Artificial neural network analysis for predicting human percutaneous absorption taking account of vehicle properties

Atobe Tomomi,Mori Masaaki,Yamashita Fumiyoshi [他],Hashida Mitsuru,Kouzuki Hirokazu
The Journal of Toxicological Sciences 40(2), 277-294, 2015
… An in silico method for predicting percutaneous absorption of cosmetic ingredients was developed by using artificial neural network (ANN) analysis to predict the human skin permeability coefficient (log Kp), taking account of the physicochemical properties of the vehicle, and the apparent diffusion coefficient (log D). …
NAID 130004904033