- 関
- transurethral
WordNet
- duct through which urine is discharged in most mammals and which serves as the male genital duct
- the 17th letter of the Hebrew alphabet
PrepTutorEJDIC
- …『につき』,…ごとに / 《文》…によって,…で,…を通じて / 《しばしば『as per』…で》…によって示された通りに,…に従って
- 尿道
UpToDate Contents
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English Journal
- Long-term efficacy and durability of botulinum-a toxin for refractory dysfunctional voiding in children.
- Vricella GJ1, Campigotto M2, Coplen DE2, Traxel EJ2, Austin PF2.Author information 1Division of Pediatric Urology, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri. Electronic address: vricellag@wudosis.wustl.edu.2Division of Pediatric Urology, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.AbstractPURPOSE: We evaluated our long-term experience with intrasphincteric botulinum toxin A injection in children with dysfunctional voiding.
- The Journal of urology.J Urol.2014 May;191(5 Suppl):1586-91. doi: 10.1016/j.juro.2013.10.034. Epub 2014 Mar 26.
- PURPOSE: We evaluated our long-term experience with intrasphincteric botulinum toxin A injection in children with dysfunctional voiding.MATERIALS AND METHODS: From January 2006 through July 2012 we saw 2,172 neurologically normal children due to dysfunctional voiding. Of patients who presented to th
- PMID 24679879
- Soluble guanylyl cyclase (sGC) degradation and impairment of nitric oxide-mediated responses in urethra from obese mice: reversal by the sGC activator BAY 60-2770.
- Alexandre EC1, Leiria LO, Silva FH, Mendes-Silvério CB, Calmasini FB, Davel AP, Mónica FZ, De Nucci G, Antunes E.Author information 1Departments of Pharmacology (E.C.A., L.O.L., F.H.S., C.B.M.S., F.B.C., F.Z.M., G.D.N., E.A.) and Anatomy, Cellular Biology, Physiology, and Biophysics (A.P.C.D.), University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.AbstractObesity has emerged as a major contributing risk factor for overactive bladder (OAB), but no study examined urethral smooth muscle (USM) dysfunction as a predisposing factor to obesity-induced OAB. This study investigated the USM relaxant machinery in obese mice and whether soluble guanylyl cyclase (sGC) activation with BAY 60-2770 [acid 4-({(4-carboxybutyl) [2-(5-fluoro-2-{[4-(trifluoromethyl) biphenyl-4-yl] methoxy} phenyl) ethyl] amino} methyl) benzoic] rescues the urethral reactivity through improvement of sGC-cGMP (cyclic guanosine monophosphate) signaling. Male C57BL/6 mice were fed for 12 weeks with a high-fat diet to induce obesity. Separate groups of animals were treated with BAY 60-2770 (1 mg/kg per day for 2 weeks). Functional assays and measurements of cGMP, reactive-oxygen species (ROS), and sGC protein expression in USM were determined. USM relaxations induced by NO (acidified sodium nitrite), NO donors (S-nitrosoglutathione and glyceryl trinitrate), and BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine] (sGC stimulator) were markedly reduced in obese compared with lean mice. In contrast, USM relaxations induced by BAY 60-2770 (sGC activator) were 43% greater in obese mice (P < 0.05), which was accompanied by increases in cGMP levels. Oxidation of sGC with ODQ [1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one] (10 μM) potentiated BAY 60-2770-induced USM responses in the lean group. Long-term oral BAY 60-2770 administration fully prevented the impairment of USM relaxations in obese mice. Reactive-oxygen species (ROS) production was enhanced, but protein expression of β1 second guanylate cyclase subunit was reduced in USM from obese mice, both of which were restored by BAY 60-2770 treatment. In conclusion, impaired USM relaxation in obese mice is associated with ROS generation and down-regulation of sGC-cGMP signaling. Prevention of sGC degradation by BAY 60-2770 ameliorates the impairment of urethral relaxations in obese mice.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2014 Apr;349(1):2-9. doi: 10.1124/jpet.113.211029. Epub 2014 Jan 13.
- Obesity has emerged as a major contributing risk factor for overactive bladder (OAB), but no study examined urethral smooth muscle (USM) dysfunction as a predisposing factor to obesity-induced OAB. This study investigated the USM relaxant machinery in obese mice and whether soluble guanylyl cyclase
- PMID 24421320
- Percutaneous injection of acrylic glue into renal allograft pseudoaneurysm for control of intractable post-biopsy hematuria.
- Lal A1, Singhal M1, Ramachandran R2, Rathi M2, Jha V2, Khandelwal N1.Author information 1Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.2Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.AbstractWe report a 44-year-old male, renal allograft recipient of 1-year duration who had two episodes of steroid responsive acute rejection. He presented with graft dysfunction for which a graft biopsy was performed and was suggestive of mixed rejection. At 2 weeks post-biopsy, patient developed severe pain over the graft site with anuria and graft hydronephrosis (HDN). The HDN and anuria intermittently settled with the passage of blood clots per-urethra. Contrast enhanced computerized tomography was suggestive of pseudoaneurysm in the graft kidney. The case was successfully managed with ultrasound guided percutaneous cyanoacrylate glue injection into the pseudoaneurysm.
- Indian journal of nephrology.Indian J Nephrol.2014 Mar;24(2):124-6. doi: 10.4103/0971-4065.127909.
- We report a 44-year-old male, renal allograft recipient of 1-year duration who had two episodes of steroid responsive acute rejection. He presented with graft dysfunction for which a graft biopsy was performed and was suggestive of mixed rejection. At 2 weeks post-biopsy, patient developed severe pa
- PMID 24701048
Japanese Journal
- 恥骨後式根治的前立腺全摘除術後の吻合部狭窄 : 頻度, 危険因子および治療法の検討
- 清水 崇,高橋 敦,市原 浩司 [他],新海 信雄,池田 健,野島 正寛,高木 良雄
- 日本泌尿器科學會雜誌 103(4), 604-609, 2012-07-20
- (目的) 根治的前立腺全摘除術後の吻合部狭窄は0.5%~32%の頻度と報告されているが,原因については十分に解明されていない.吻合部狭窄の頻度,治療法について検討しその原因を探索した. (対象と方法) 当院で根治的前立腺全摘除術を施行した129例を対象とした.吻合部狭窄の治療法と狭窄診断までの期間の関係について調べた.合併疾患(高血圧,糖尿病,心血管疾患,脳梗塞,喫煙歴)と吻合部狭窄の関係について …
- NAID 10030496436
- Bladder dysfunction after acute urinary retention in the rats: a novel over active bladder model.
- Saito Motoaki,Shimizu Shogo,Kinoshita Yukako,Satoh Itaru,Shomori Kohei,Dimitriadis Fotios,Satoh Keisuke
- Molecular and Cellular Biochemistry 333(1-2), 109-114, 2010-01
- … AUR was induced by clamping the distal urethra of each rat with a small clip, and then infusing 3 ml (0.6 ml/min) of saline with an infusion pump through a transurethral catheter (22G). … The voiding behavior studies showed significant increase in micturition frequency per day and decrease in single voiding volume 3 days after the induction of AUR, and this voiding behavior was continued for more than 2 weeks. …
- NAID 120002854452
- 原発性膀胱尿管逆流症に対する内視鏡下三角部形成術II
- 辻 克和,藤田 高史,木村 亨 [他],平野 篤志,初瀬 勝朗,古川 亨,田中 國晃,絹川 常郎,野尻 佳克,岡村 菊夫,小野 佳成,大島 伸一
- 日本泌尿器科學會雜誌 97(3), 583-590, 2006-03-20
- (目的)われわれは,内視鏡的三角部形成術に代わる低侵襲性逆流防止手術として2000年に折笠法を内視鏡手術にアレンジした内視鏡的三角部形成術II(ET II)を開発した.この手技と治療成績を報告しその有用性を検討した.(対象と方法)2000年5月より2002年8月まで,成人9例(18〜64歳,平均34.1歳)と小児(5〜14歳,平均9.3歳)の6例に施行した.全例女性で逆流は23尿管であった.逆流の …
- NAID 110004706563
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Related Pictures
★リンクテーブル★
[★]
- 関
- per urethra
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- 英
- transurethral、per urethra
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- (商)~につき/ごとに
- ~で、~によって。~に託して
- ~によれば
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- 関
- protein efficiency ratio
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- 10の-12乗
- 関
- pico