WordNet
- any of various enzymes that move a chemical group from one compound to another compound
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/12 19:52:07」(JST)
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The Peptidyl transferase is an aminoacyltransferase (EC 2.3.2.12) as well as the primary enzymatic function of the ribosome, which forms peptide bonds between adjacent amino acids using tRNAs during the translation process of protein biosynthesis.
Peptidyl transferase activity is carried out by the ribosome. Peptidyl transferase activity is not mediated by any ribosomal proteins but by ribosomal RNA (rRNA), a ribozyme. This RNA relic is the most significant piece of evidence supporting the RNA World hypothesis.
- In Prokaryotes, the 50S (23S component) ribosome subunit contains the peptidyl transferase component and acts as a ribozyme.
- In Eukaryotes, the 60S (28S component) ribosome subunit contains the peptidyl transferase component and acts as the ribozyme.
Peptidyl transferases are not limited to translation, but there are relatively few enzymes with this function.
Contents
- 1 Antibiotic target
- 2 See also
- 3 References
- 4 External links
Antibiotic target
The following protein synthesis inhibitors target peptidyl transferase:
- Chloramphenicol binds[1] to A2451 and A2452 residues in the 23S rRNA of the ribosome and inhibits peptide bond formation.
- Pleuromutilins also bind to peptidyl transferase.[2]
- Macrolide antibiotics are thought to inhibit peptidyl transferase, in addition to inhibiting ribosomal translocation.[3]
See also
- Transferase
- Translation
- Enzyme
References
- ^ Gu Z, Harrod R, Rogers EJ, Lovett PS (June 1994). "Anti-peptidyl transferase leader peptides of attenuation-regulated chloramphenicol-resistance genes". Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5612–6. doi:10.1073/pnas.91.12.5612. PMC 44046. PMID 7515506.
- ^ Long, Katherine S; Hansen, LH; Jakobsen, L; Vester, B (April 2006). "Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center" (PDF). Antimicrobial Agents and Chemotherapy 50 (4): 1458–1462. doi:10.1128/AAC.50.4.1458-1462.2006. PMC 1426994. PMID 16569865.
- ^ Protein synthesis inhibitors: macrolides mechanism of action animation. Classification of agents Pharmamotion. Author: Gary Kaiser. The Community College of Baltimore County. Retrieved on July 31, 2009
External links
- Peptidyl transferases at the US National Library of Medicine Medical Subject Headings (MeSH)
Transferases: acyltransferases (EC 2.3)
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2.3.1: other than amino-acyl groups |
- acetyltransferases: Acetyl-Coenzyme A acetyltransferase
- N-Acetylglutamate synthase
- Choline acetyltransferase
- Dihydrolipoyl transacetylase
- Acetyl-CoA C-acyltransferase
- Beta-galactoside transacetylase
- Chloramphenicol acetyltransferase
- N-acetyltransferase
- Serotonin N-acetyl transferase
- HGSNAT
- ARD1A
- Histone acetyltransferase
- palmitoyltransferases: Carnitine O-palmitoyltransferase
- Serine C-palmitoyltransferase
- other: Acyltransferase like 2
- Aminolevulinic acid synthase
- Beta-ketoacyl-ACP synthase
- Glyceronephosphate O-acyltransferase
- Lecithin—cholesterol acyltransferase
- Glycerol-3-phosphate O-acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- ABHD5
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2.3.2: Aminoacyltransferases |
- Gamma-glutamyl transpeptidase
- Peptidyl transferase
- Transglutaminase
- Tissue transglutaminase
- Keratinocyte transglutaminase
- Factor XIII
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2.3.3: converted into alkyl on transfer |
- Citrate synthase
- ATP citrate lyase
- HMG-CoA synthase
- Malate synthase
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition.
- Svetlov MS, Plessa E, Chen CW, Bougas A, Krokidis MG, Dinos GP, Polikanov YS.
- RNA (New York, N.Y.). 2019 May;25(5)600-606.
- The 70S ribosome is a major target for antibacterial drugs. Two of the classical antibiotics, chloramphenicol (CHL) and erythromycin (ERY), competitively bind to adjacent but separate sites on the bacterial ribosome: the catalytic peptidyl transferase center (PTC) and the nascent polypeptide exit tu
- PMID 30733327
- Protein expression profiles in Bathymodiolus azoricus exposed to cadmium.
- Company R, Antúnez O, Cosson RP, Serafim A, Shillito B, Cajaraville M, Bebianno MJ, Torreblanca A.
- Ecotoxicology and environmental safety. 2019 Apr;171()621-630.
- Proteomic changes in the "gill-bacteria complex" of the hydrothermal vent mussel B. azoricus exposed to cadmium in pressurized chambers ((Incubateurs Pressurises pour l'Observation en Culture d'Animaux Marins Profonds - IPOCAMP) were analyzed and compared with the non-exposed control group. 2-D Fluo
- PMID 30658297
- Structural insights into unique features of the human mitochondrial ribosome recycling.
- Koripella RK, Sharma MR, Risteff P, Keshavan P, Agrawal RK.
- Proceedings of the National Academy of Sciences of the United States of America. 2019 Apr;().
- Mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing proteins that are essential for oxidative phosphorylation (ATP generation). Despite their common ancestry with bacteria, the composition and structure of the human mitoribosome and its translational factors are signif
- PMID 30962385
Japanese Journal
- Single mutations introduced in the essential ribosomal proteins L3 and S10 cause a sporulation defect in Bacillus subtilis
- Akanuma Genki,Suzuki Shota,Yano Koichi,Nanamiya Hideaki,Natori Yousuke,Namba Eri,Watanabe Kazuya,Tagami Kazumi,Takeda Takuya,Iizuka Yuka,Kobayashi Ako,Ishizuka Morio,Yoshikawa Hirofumi,Kawamura Fujio
- The Journal of General and Applied Microbiology 59(2), 105-117, 2013
- … Mutant cells harboring the G52D mutation in the L3 ribosomal protein, which is located at the peptidyl transferase center of 50S, accumulated 30S subunit at 45°C, probably due to a defect in 50S formation, and exhibited a reduction in the sporulation frequency at high temperature. …
- NAID 130004449359
- 田村 浩二
- Viva origino 39(1-4), 31-37, 2012-06-20
- … The ribosome is a supercomplex of ribonucleoprotein particles containing both RNAs and proteins, and the peptide bond is produced on the peptidyl transferase center (PTC) of the large subunit of the ribosome. …
- NAID 110009470535
- ONIOM Study of a Proton Shuttle-Catalyzed Stepwise Mechanism for Peptide Bond Formation in the Ribosome
- Fukushima Kazuaki,Iwahashi Hideo,Nishikimi Morimitsu
- Bulletin of the Chemical Society of Japan 85(10), 1093-1101, 2012
- … The exact reaction mechanism for peptide bond formation in the peptidyl transferase center of the ribosome is, however, still unknown. …
- NAID 130004152991
Related Links
- Atomic resolution crystal structures of the large subunit published since the middle of August 2000 prove that the peptidyl transferase center of the ribosome, which is the site of peptide-bond formation, is composed entirely of RNA ...
- Barta A, Kuechler E. Part of the 23S RNA located in the 11S RNA fragment is a constituent of the ribosomal peptidyltransferase centre. FEBS Lett. 1983 Nov 14; 163 (2):319–323. [PubMed] Barta A, Steiner G, Brosius J, Noller HF ...
- peptidyl transferase png 852 x 670 - png - 336 Ko chem.ucsb.edu/~molvisual... Methyl Transferase Mech JPG "1 http www alltheweb com.." 679 x 867 - jpeg - 70 Ko cmgm.stanford.edu/wusage... CLS 3153 Carbamoyl Transferase ...
Related Pictures
★リンクテーブル★
[★]
- 英
- peptidyl transferase、peptidyltransferase
- 関
- ペプチジルトランスフェラーゼ、ペプチド転移酵素
[★]
ペプチジルトランスフェラーゼ、ペプチド生成酵素
- 関
- peptidyl transferase、transpeptidase
[★]
- 英
- peptidyl transferase
- 関
- ペプチジルトランスフェラーゼ、ペプチド生成酵素
[★]
- 英
- [[]]
- 同
- peptidyl transferase
- 関
- [[]]
-peptidyltransferase
- 同
- peptidyl transferase
[★]
- 関
- lyase、synthase、transposase
[★]
トランスフェラーゼ