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any of various enzymes that move a chemical group from one compound to another compound

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/22 08:52:56」(JST)

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In biochemistry, a transferase is an enzyme that catalyzes the transfer of a functional group (e.g., a methyl or phosphate group) from one molecule (called the donor) to another (called the acceptor). For example, an enzyme that catalyzed this reaction would be a transferase:

A–X + B → A + B–X

In this example, A would be the donor, and B would be the acceptor. The donor is often a coenzyme.

Nomenclature

Proper names of transferases are formed as "donor:acceptor grouptransferase." However, other names are much more common. The common names of transferases are often formed as "acceptor grouptransferase" or "donor grouptransferase." For example, a DNA methyltransferase is a transferase that catalyzes the transfer of a methyl group to a DNA acceptor.

Classification

Transferases are classified as EC 2 in the EC number classification. Transferases can be further classified into nine subclasses:

EC 2.1 includes enzymes that transfer one-carbon groups (methyltransferase)
EC 2.2 includes enzymes that transfer aldehyde or ketone groups
EC 2.3 includes acyltransferases
EC 2.4 includes glycosyltransferases
EC 2.5 includes enzymes that transfer alkyl or aryl groups, other than methyl groups
EC 2.6 includes enzymes that transfer nitrogenous groups (transaminase)
EC 2.7 includes enzymes that transfer phosphorus-containing groups (phosphotransferase, including polymerase and kinase)
EC 2.8 includes enzymes that transfer sulfur-containing groups (sulfurtransferase and sulfotransferase)
EC 2.9 includes enzymes that transfer selenium-containing groups

References

EC 2 Introduction from the Department of Chemistry at Queen Mary, University of London

UpToDate Contents

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English Journal

Acceptor specificities and selective inhibition of recombinant human Gal- and GlcNAc-transferases that synthesize core structures 1, 2, 3 and 4 of O-glycans.

Gao Y, Aryal RP, Ju T, Cummings RD, Gahlay G, Jarvis DL, Matta KL, Vlahakis JZ, Szarek WA, Brockhausen I.SourceDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada; Department of Medicine, Division of Rheumatology, Queen's University, Kingston, Ontario, Canada.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Aug;1830(8):4274-81. doi: 10.1016/j.bbagen.2013.04.001. Epub 2013 Apr 8.
BACKGROUND: Modifications of proteins by O-glycosylation determine many of the properties and functions of proteins. We wish to understand the mechanisms of O-glycosylation and develop inhibitors that could affect glycoprotein functions and alter cellular behavior.METHODS: We expressed recombinant s
PMID 23578692

Association between the genetic polymorphisms of glutathione S-transferase (GSTM1 and GSTT1) and the clinical manifestations in sickle cell anemia.

de Oliveira Filho RA, Silva GJ, de Farias Domingos I, Hatzlhofer BL, da Silva Araújo A, de Lima Filho JL, Bezerra MA, Martins DB, de Araújo RF.SourceLaboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife -PE, Brazil.
Blood cells, molecules & diseases.Blood Cells Mol Dis.2013 Aug;51(2):76-9. doi: 10.1016/j.bcmd.2013.03.003. Epub 2013 Apr 13.
The hereditary deficiency of antioxidant enzymes when associated with sickle cell anemia (SCA) further contributes to the oxidation of hemoglobin S, which increases the formation of degradation products of this hemoglobin. The glutathione S transferases play an important role in the conjugation of g
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PI3Ks and small GTPases in neutrophil migration: two sides of the same coin.

Germena G, Hirsch E.SourceDepartment of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.
Molecular immunology.Mol Immunol.2013 Aug;55(1):83-6. doi: 10.1016/j.molimm.2012.10.004. Epub 2012 Nov 5.
Cell migration is a key event in physiological processes such as embryonic development, tissue repair, angiogenesis and immune responses. Alteration of the migration program is an important component in multiple pathologies, including chronic inflammation, autoimmunity and tumor metastasis. Understa
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Japanese Journal

受賞論文新規糖転移酵素の発見とその産業利用

福田惠温
応用糖質科学 : 日本応用糖質科学会誌 5(1), 11-16, 2015
NAID 40020370126

Roles of Enzymes in Glycogen Metabolism and Degradation in Escherichia coli

Journal of Applied Glycoscience 62(2), 37-45, 2015
… However, these enzymes in bacteria, most of which are glycosyl transferases or glycosidases, have not been fully characterized. …
NAID 130005070810

Roles of Enzymes in Glycogen Metabolism and Degradation in Escherichia coli

Journal of Applied Glycoscience advpub(0), 2015
… However, these enzymes in bacteria, most of which are glycosyl transferases or glycosidases, have not been fully characterized. …
NAID 130005060851

Related Pictures

Transferases couplings are called prenyl transferases Figure 3 : Glutathione : S: -transferases Transferase - Wikipedia, the free transferases (see Fig. Action of glutathione S-transferases reaction is Transferases ?