WordNet

a salt or ester of citric acid
cause to form a salt or ester of citric acid

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クエン酸塩

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1. クエン酸クロミフェンによる排卵誘発 ovulation induction with clomiphene citrate
2. 排卵誘発の概要 overview of ovulation induction
3. アフェレシス治療（血漿交換または血球アフェレシス）：合併症 therapeutic apheresis plasma exchange or cytapheresis complications
4. 成人における再発性カルシウム結石の予防 prevention of recurrent calcium stones in adults
5. 血液透析における緊急および長期ブラッドアクセスとしての中心静脈カテーテル central catheters for acute and chronic hemodialysis access

English Journal

Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration.

Dönmez OA1, Aşçi B, Bozdoğan A, Sungur S.Author information 1Yildiz Technical University, Department of Chemistry, Istanbul, Turkey. oziaksu@yahoo.comAbstractA simple and rapid analytical procedure was proposed for the determination of chromatographic peaks by means of partial least squares multivariate calibration (PLS) of high-performance liquid chromatography with diode array detection (HPLC-DAD). The method is exemplified with analysis of quaternary mixtures of potassium guaiacolsulfonate (PG), guaifenesin (GU), diphenhydramine HCI (DP) and carbetapentane citrate (CP) in syrup preparations. In this method, the area does not need to be directly measured and predictions are more accurate. Though the chromatographic and spectral peaks of the analytes were heavily overlapped and interferents coeluted with the compounds studied, good recoveries of analytes could be obtained with HPLC-DAD coupled with PLS calibration. This method was tested by analyzing the synthetic mixture of PG, GU, DP and CP. As a comparison method, a classsical HPLC method was used. The proposed methods were applied to syrups samples containing four drugs and the obtained results were statistically compared with each other. Finally, the main advantage of HPLC-PLS method over the classical HPLC method tried to emphasized as the using of simple mobile phase, shorter analysis time and no use of internal standard and gradient elution.
Talanta.Talanta.2011 Feb 15;83(5):1601-5. doi: 10.1016/j.talanta.2010.11.054. Epub 2010 Nov 30.
A simple and rapid analytical procedure was proposed for the determination of chromatographic peaks by means of partial least squares multivariate calibration (PLS) of high-performance liquid chromatography with diode array detection (HPLC-DAD). The method is exemplified with analysis of quaternary
PMID 21238758

[Bioequivalence evaluation of orally disintegrating tablet of pentoxyverine citrate].

Lin MQ1, Cai Y, Zhang W, Wu XQ, Rao JJ, Liu SW.Author information 1School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. lin-mingqin@163.comAbstractOBJECTIVE: To evaluate the bioequivalence of orally disintegrating tablets of pentoxyverine citrate (tested preparation) in healthy male volunteers.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.Nan Fang Yi Ke Da Xue Xue Bao.2010 Jul;30(7):1621-3.
OBJECTIVE: To evaluate the bioequivalence of orally disintegrating tablets of pentoxyverine citrate (tested preparation) in healthy male volunteers.METHODS: A single oral dose of the tested and reference preparations at 25 mg were given to 20 healthy volunteers in a randomized two-period cross-over
PMID 20650784

A sensitive liquid chromatography-electrospray ionization-mass spectrometry method for the simultaneous determination of pentoxyverine citrate and guaifenesin in human plasma---application to pharmacokinetic and bioequivalence studies.

Wen J1, Zhang H, Xia C, Hu X, Xu W, Cheng X, Gao J, Xiong Y.Author information 1Institute of Clinical Pharmacology, College of Medicine, Nanchang University, 461 Bayi Road, Nanchang, Jiangxi, People's Republic of China.AbstractA sensitive and specific liquid chromatography-electrospray ionization-mass spectrometry method for the identification and quantification of pentoxyverine citrate and guaifenesin in human plasma has been developed. After extraction from plasma samples by ethyl acetate, the internal standard and analytes were separated by high-performance liquid chromatographic on a Shim-pack VP-ODS C(18) column (150 x 2.0 mm) using a mobile phase consisting of A (methanol) and B (0.4% glacial acetic acid and 4 mmol/L ammonium acetate) (A:B, 43 : 57). Analysis was performed on a Shimadzu LC/MS-2010A in selected ion monitoring mode with a positive electrospray ionization interface. The method was linear in the concentration range of 1.0-640.0 ng/mL for pentoxyverine citrate and 0.025-6.4 microg/mL for guaifenesin. The inter- and intra- precision were all within 12% and accuracy ranged from 85 to 115%.The lower limits of quantification were 1.0 ng/mL for pentoxyverine citrate and 25.0 ng/mL for guaifenesin. The extraction recovery was on average 81.95% for pentoxyverine citrate and 89.03% for guaifenesin. This is the first assay method reported for the simultaneous determination of pentoxyverine citrate and guaifenesin in plasma using one chromatographic run.
Biomedical chromatography : BMC.Biomed Chromatogr.2010 Apr;24(4):351-7. doi: 10.1002/bmc.1298.
A sensitive and specific liquid chromatography-electrospray ionization-mass spectrometry method for the identification and quantification of pentoxyverine citrate and guaifenesin in human plasma has been developed. After extraction from plasma samples by ethyl acetate, the internal standard and anal
PMID 19634120