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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/26 14:32:09」(JST)

Pazufloxacin (INN) is a fluoroquinolone antibiotic.^[1] It is sold in Japan under the brand names Pasil and Pazucross.

References

^ Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy. 47 Suppl 3: 3–8; discussion 44–8. doi:10.1159/000057838. PMID 11549783.

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Mutant prevention concentrations of levofloxacin, pazufloxacin and ciprofloxacin for A. baumannii and mutations in gyrA and parC genes.

Sun C1, Hao J2, Dou M3, Gong Y4.
The Journal of antibiotics.J Antibiot (Tokyo).2015 May;68(5):313-7. doi: 10.1038/ja.2014.150. Epub 2014 Nov 5.
Fluoroquinolones are antimicrobial agents that are widely used clinically, but the increasing resistance of Acinetobacter baumannii (A. baumannii) to these agents is a matter of concern. We investigated mutant prevention concentrations (MPCs) of three fluoroquinolones, levofloxacin (LVX), pazufloxac
PMID 25351948

Heterologous strategy enhancing the sensitivity of the fluorescence polarization immunoassay of clinafloxacin in goat milk.

Chen J1, Shanin IA2,3, Lv S1, Wang Q4, Mao C5, Xu Z1, Sun Y1, Wu Q1, Eremin SA2,3, Lei H1.
Journal of the science of food and agriculture.J Sci Food Agric.2015 Apr 23. doi: 10.1002/jsfa.7228. [Epub ahead of print]
BACKGROUND: Clinafloxacin is used for the treatment of disease in food-producing animals, e.g. Brucella melitensis, which often occurs in goats; however, the clinafloxacin residue in goat milk may harm human health and result in the development of drug-resistant bacterial strains or allergies. Despi
PMID 25914021

Characterization of plasmid-mediated quinolone resistance determinants in Klebsiella pneumoniae and Escherichia coli from Tokai, Japan.

Okade H1, Nakagawa S2, Sakagami T2, Hisada H2, Nomura N2, Mitsuyama J3, Yamagishi Y4, Mikamo H5.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.J Infect Chemother.2014 Dec;20(12):778-83. doi: 10.1016/j.jiac.2014.08.018. Epub 2014 Sep 17.
The spread of plasmid-mediated quinolone resistance (PMQR) determinants was evaluated in 150 ceftazidime or cefotaxime-resistant clinical isolates of Klebsiella pneumoniae and Escherichia coli from Tokai, Japan between 2008 and 2011. In this study, qnrB, qnrS, and aac(6')-Ib-cr genes were detected i
PMID 25239060

Successful Additional Corticosteroid Treatment in a Patient with Mycoplasma pneumoniae Pneumonia in whom a Monobacterial Infection was Confirmed by a Molecular Method Using Bronchoalveolar Lavage Fluid

Pazufloxacin
Systematic (IUPAC) name
	(3R)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-1H,7H- [1,3]oxazino[5,4,3-ij]quinoline-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	127046-18-8
ATC code	J01MA18
PubChem	CID 65957
ChemSpider	59360
UNII	4CZ1R38NDI
Chemical data
Formula	C16H15FN2O4
Molecular mass	318.29 g/mol
	SMILES C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4(CC4)N)F)C(=O)O;
	InChI InChI=1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1; Key:XAGMUUZPGZWTRP-ZETCQYMHSA-N ;
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