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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/14 17:12:58」(JST)

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Paromomycin is an aminoglycoside antibiotic, first isolated from Streptomyces krestomuceticus in the 1950s.^[1] It was discovered by Parke Davis now Pfizer and introduced as Humatin in 1960.^[2] It is also called monomycin and aminosidine;^[3]

Uses[edit]

It is an antibiotic used to treat intestinal infections such as cryptosporidiosis ^[4] and amoebiasis,^[5] and other diseases like leishmaniasis.^[6] Paromomycin was demonstrated to be effective against cutaneous leishmaniasis in clinical studies in the USSR in the 1960s, and in trials with visceral leishmaniasis in the early 1990s.^[3]

The route of administration is intramuscular injection and capsule.
Paromomycin topical cream with or without gentamicin is an effective treatment for ulcerative cutaneous leishmaniasis, according to the results of a phase 3, randomized, double-blind, parallel group–controlled trial.^[7]

Mechanism[edit]

Paromomycin is a protein synthesis inhibitor in non-resistant cells by binding to 16S ribosomal RNA.^[8] This broad spectrum antibiotic soluble in water, is very similar in action to Neomycin. Antimicrobial activity of Paromomycin against Escherichia coli and Staphylococcus aureus has been shown.^[9]

References[edit]

^ Davidson R.N., den Boer M., Ritmeijer K. (2008). "Paromomycin". Transactions of the Royal Society of Tropical Medicine and Hygiene 103 (7): 653–60. doi:10.1016/j.trstmh.2008.09.008. PMID 18947845.
^ Page 1166. http://books.google.co.in/books?id=XCsJgUnclbcC&pg=PA1257&dq=Pharmaceutical+Manufacturing+Encyclopedia,+Volume+2&hl=en&sa=X&ei=9V7iT8mqJoOIrAfe4P2zAw&ved=0CDoQ6AEwAA#v=onepage&q=Pharmaceutical%20Manufacturing%20Encyclopedia%2C%20Volume%202&f=false
^ ^a ^b Neal R.A. et al. (1994). "Aminosidine ointments for the treatment of experimental cutaneous leishmaniasis". Transactions of the Royal Society of Tropical Medicine and Hygiene 88 (2): 223–5. doi:10.1016/0035-9203(94)90307-7. PMID 8036682.
^ Sweetman S.C. (Editor). (2002). Martindale: the complete drug reference. 33rd ed. London: Pharmaceutical Press
^ "paromomycin" at Dorland's Medical Dictionary
^ Sundar S, Jha TK, Thakur CP, Sinha PK, Bhattacharya SK (June 2007). "Injectable paromomycin for visceral leishmaniasis in India". N. Engl. J. Med. 356 (25): 2571–81. doi:10.1056/NEJMoa066536. PMID 17582067. Cite uses deprecated parameters (help)
^ N Engl J Med. 2013;368:524-532
^ Vicens, Quentin; Eric Westhof (August 2001). "Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site". Structure 9 (8): 647–658. doi:10.1016/S0969-2126(01)00629-3. PMID 11587639. Retrieved 2007-02-10. Cite uses deprecated parameters (help)
^ "Paromomycin" (pdf). Toku-E. 2010-01-12. Retrieved 2012-06-11.

UpToDate Contents

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1. 抗原虫治療 antiprotozoal therapies
2. 皮膚リーシュマニア症の治療 treatment of cutaneous leishmaniasis
3. 赤痢アメーバによる腸菅アメーバ症 intestinal entamoeba histolytica amebiasis
4. 内臓リーシュマニア症の治療 treatment of visceral leishmaniasis
5. ジアルジア症の治療および予防 treatment and prevention of giardiasis

English Journal

Cryptosporidiosis: A rare and severe infection in a pediatric renal transplant recipient.

Acikgoz Y, Ozkaya O, Bek K, Genc G, Sensoy SG, Hokelek M.SourceDepartments of Pediatric Nephrology Pediatric Infection Microbiology, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, Turkey.
Pediatric transplantation.Pediatr Transplant.2012 Jun;16(4):E115-9. doi: 10.1111/j.1399-3046.2011.01473.x. Epub 2011 Feb 15.
Acikgoz Y, Ozkaya O, Bek K, Genc G, Sensoy SG, Hokelek M. Cryptosporidiosis: A rare and severe infection in a pediatric renal transplant recipient. Abstract: Cryptosporidium is an intracellular protozoan parasite that causes gastroenteritis in human. In immunocompromised individuals, cryptosporid
PMID 21320246

Fulminant amoebic colitis mimicking intestinal vasculitis in a patient with systemic lupus erythematosus.

Lee J, Jung HS, Nam HC, Kwok SK, Ju J, Park KS, Kim HY, Park SH.SourceDivision of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, South Korea.
Lupus.Lupus.2012 May 8. [Epub ahead of print]
Colitis in patients with systemic lupus erythematosus (SLE) is quite rare. It can be caused by intestinal vasculitis, mesenteric vascular thrombosis, concomitant inflammatory bowel disease or infectious colitis. It is important to make an accurate and early diagnosis as the treatments for each condi
PMID 22570337

Japanese Journal

Determination of paromomycin residues in turkey tissues by liquid chromatography/mass spectrometry

RONA K.,KLAUSZ G.,KELLER E.,SZAKAY M.,LACZAY P.,SHEM-TOV M.,SZEKELY-KORMOCZY P.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(30), 3792-3798, 2009-11-15
NAID 10028028805

Agrobacterium-mediated genetic transformation of radish (Raphanus sativus L.)

CHO Mi Ae,MIN Sung Ran,KO Suk Min,LIU Jang Ryol,CHOI Pil Son
Plant biotechnology 25(2), 205-208, 2008-03-01
… Jin Ju Dae Pyong), hypocotyl explants were cultured on Murashige and Skoog medium containing 4 mg l−1 AgNO3, 5 mg l−1 acetosyringone, 4 mg l−1 6-benzyladenine, and 3 mg l−1 α-naphthaleneacetic acid in addition to either 10 mg l−1 hygromycin or 100 mg l−1 paromomycin after co-cultivation with disarmed Agrobacterium tumefaciens harboring a plant expression binary vector. …
NAID 10021913172

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リンク元

「パロモマイシン」

Paromomycin
Systematic (IUPAC) name
	(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2S,3S,4R,6S)-; 4,6-diamino-2-[(2S,3R,4R,5R)-4-[(2R,3R,4R,5R,6S)-; 3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]; oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-; 3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a601098
Pregnancy cat.	B (US)
Legal status	Rx only U.S.
Routes	Oral, intramuscular
Pharmacokinetic data
Bioavailability	None
Metabolism	None
Half-life	?
Excretion	Fecal
Identifiers
CAS number	1263-89-4
ATC code	A07AA06
PubChem	CID 441375
DrugBank	DB01421
ChemSpider	390117
ChEBI	CHEBI:7934
ChEMBL	CHEMBL370143
Chemical data
Formula	C23H47N5O18S
Mol. mass	615.629 g/mol
	SMILES O=S(=O)(O)O.O([C@H]3[C@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]1O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]1N)[C@H]2O)[C@@H](O)[C@H](N)C[C@@H]3N)[C@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4N)CO;
	InChI InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 ; Key:LJRDOKAZOAKLDU-UDXJMMFXSA-N ;
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　　[★]

英: paromomycin, PRM
同: ヒドロキシマイシン hydroxymycin
化: 硫酸パロモマイシン paromomycin sulfate
商: アミノサイジン、アメパロモ、ヒドロキシマイシン
関: 抗菌薬

分類

抗菌薬

アミノグリコシド系抗菌薬

[Davidson2008-1] Davidson R.N., den Boer M., Ritmeijer K. (2008). "Paromomycin". Transactions of the Royal Society of Tropical Medicine and Hygiene 103 (7): 653–60. doi:10.1016/j.trstmh.2008.09.008. PMID 18947845.

[2] Page 1166. http://books.google.co.in/books?id=XCsJgUnclbcC&pg=PA1257&dq=Pharmaceutical+Manufacturing+Encyclopedia,+Volume+2&hl=en&sa=X&ei=9V7iT8mqJoOIrAfe4P2zAw&ved=0CDoQ6AEwAA#v=onepage&q=Pharmaceutical%20Manufacturing%20Encyclopedia%2C%20Volume%202&f=false

[Neal1994-3] Neal R.A. et al. (1994). "Aminosidine ointments for the treatment of experimental cutaneous leishmaniasis". Transactions of the Royal Society of Tropical Medicine and Hygiene 88 (2): 223–5. doi:10.1016/0035-9203(94)90307-7. PMID 8036682.

[4] Sweetman S.C. (Editor). (2002). Martindale: the complete drug reference. 33rd ed. London: Pharmaceutical Press

[5] "paromomycin" at Dorland's Medical Dictionary

[pmid17582067-6] Sundar S, Jha TK, Thakur CP, Sinha PK, Bhattacharya SK (June 2007). "Injectable paromomycin for visceral leishmaniasis in India". N. Engl. J. Med. 356 (25): 2571–81. doi:10.1056/NEJMoa066536. PMID 17582067. Cite uses deprecated parameters (help)

[7] N Engl J Med. 2013;368:524-532

[8] Vicens, Quentin; Eric Westhof (August 2001). "Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site". Structure 9 (8): 647–658. doi:10.1016/S0969-2126(01)00629-3. PMID 11587639. Retrieved 2007-02-10. Cite uses deprecated parameters (help)

[9] "Paromomycin" (pdf). Toku-E. 2010-01-12. Retrieved 2012-06-11.

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案内

paromomycin