WordNet
- any malignant tumor derived from epithelial tissue; one of the four major types of cancer
PrepTutorEJDIC
- がん,がん腫
- 副甲状腺の,上皮小体の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/06 13:11:49」(JST)
[Wiki en表示]
| Parathyroid carcinoma |
| Classification and external resources |
| ICD-10 |
C75.0 |
| ICD-9 |
194.1 |
| DiseasesDB |
9628 |
| MedlinePlus |
007264 |
| eMedicine |
med/1754 |
| NCI |
Parathyroid carcinoma |
| MeSH |
D010282 |
Parathyroid carcinoma is a rare malignant neoplasm resulting in parathyroid adenoma to carcinoma progression.[1] It forms in tissues of one or more of the parathyroid glands (four pea-sized glands in the neck that make parathyroid hormone, which helps the body store and use calcium).
It is rare,[2] and much less common than parathyroid adenoma.
It can be difficult to excise.[3]
Contents
- 1 Risk factors
- 2 Signs and Symptoms
- 3 Treatment
- 4 References
- 5 External links
Risk factors
Parathyroid cancer occurs in midlife at the same rate in men and women.
Conditions that appear to result in an increased risk of parathyroid cancer include multiple endocrine neoplasia type 1,[4] autosomal dominant familial isolated hyperparathyroidism[4] and hyperparathyroidism-jaw tumor syndrome[1] (which also is hereditary).[1] Parathyroid cancer has also been associated with external radiation exposure, but, most reports describe an association between radiation and the more common parathyroid adenoma.[4]
Signs and Symptoms
Most patients experience moderate to severe hypercalcemia and high parathyroid hormone levels. A large mass in the neck is often seen, and renal and bone abnormalities are common.[1]
Treatment
Parathyroid carcinoma is sometimes diagnosed during surgery for primary hyperparathyroidism. If the surgeon suspects carcinoma based on severity or invasion of surrounding tissues by a firm parathyroid tumor, aggressive excision is performed, including the thyroid and surrounding tissues as necessary.[1]
Agents such as calcimimetics (for example, Cinacalcet) are used to mimic calcium and are able to activate the parathyroid calcium-sensing receptor (making the parathyroid gland "think" we have more calcium than we actually do), therefore lowering the calcium level, in an attempt to decrease the hypercalcemia.
References
- ^ a b c d e Hu MI, Vassilopoulou-Sellin R, Lustig R, Lamont JP. "Thyroid and Parathyroid Cancers" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. 11 ed. 2008.
- ^ Lee JE (July 2005). "Predicting the presence of parathyroid carcinoma". Ann. Surg. Oncol. 12 (7): 513–4. doi:10.1245/ASO.2005.03.904. PMID 15952075.
- ^ "Endocrine Pathology". Retrieved 2009-05-08.
- ^ a b c Parathyroid Cancer Treatment at National Cancer Institute. Last Modified: 03/11/2009.
External links
- Parathyroid cancer entry in the public domain NCI Dictionary of Cancer Terms
- Parathyroid Carcinoma (Medscape eMedicine)
- Cancer Management Handbook: Thyroid and Parathyroid Cancers
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
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Tumors: endocrine gland neoplasia (C73–C75/D34–D35, 193–194/226–227)
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Pancreas/
islets of Langerhans |
- neuroendocrine tumors/islet cell carcinoma: α: Glucagonoma
- β: Insulinoma
- δ: Somatostatinoma
- G: Gastrinoma
- VIPoma
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Hypothalamic/
pituitary axes
+parathyroid |
| Pituitary |
- Pituitary adenoma: Prolactinoma
- ACTH-secreting pituitary adenoma
- GH-secreting pituitary adenoma
|
|
| Thyroid |
- Thyroid cancer (malignant): epithelial cell carcinoma
- Papillary
- Follicular/Hurthle cell
- parafollicular cell
- Anaplastic
- Lymphoma
- Squamous cell carcinoma
- Benign: Thyroid adenoma
- Struma ovarii
|
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| Parathyroid |
- Parathyroid adenoma
- Parathyroid carcinoma
|
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| Adrenal tumor |
- adrenal cortex
- Adrenocortical adenoma
- Adrenocortical carcinoma
- adrenal medulla
- Pheochromocytoma
- Neuroblastoma
- see also: Paraganglioma
|
|
| Gonads |
|
|
|
| Pinealoma |
- Pinealoblastoma
- Pineocytoma
|
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| MEN |
|
|
|
|
|
noco (d)/cong/tumr, sysi/epon
|
proc, drug (A10/H1/H2/H3/H5)
|
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UpToDate Contents
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English Journal
- Bone resorption in parathyroid carcinoma.
- Naderi N, McCurdy MT, Reed RM.
- BMJ case reports.BMJ Case Rep.2014 May 20;2014. pii: bcr2013203396. doi: 10.1136/bcr-2013-203396.
- PMID 24849640
- CDC73 intragenic deletion in familial primary hyperparathyroidism associated with parathyroid carcinoma.
- Korpi-Hyövälti E1, Cranston T, Ryhänen E, Arola J, Aittomäki K, Sane T, Thakker RV, Schalin-Jäntti C.
- The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2014 May 13:jc20141481. [Epub ahead of print]
- Context: CDC73 mutations frequently underlie the hyperparathyroidism-jaw tumor syndrome (HPT-JT), familial isolated hyperparathyroidism (FIHP) and parathyroid carcinoma. It has also been suggested that CDC73 deletion analysis should be performed in those patients without CDC73 mutations. Objective:
- PMID 24823466
Japanese Journal
- 3. 副甲状腺の外科(<特集>内分泌外科の現状と将来)
- 高Ca血症を呈し急激な転帰をとった肺多形癌胃転移の1例
- 中澤 俊之,廣野 靖夫,小練 研可,永野 秀樹,村上 真,五井 孝憲,飯田 敦,片山 寛次,伊藤 浩史,山口 明夫
- 日本消化器病學會雜誌 = The Japanese journal of gastro-enterology 109(7), 1204-1212, 2012-07-05
- 69歳男性．全身倦怠感，咳嗽，食欲不振の精査で行った内視鏡検査で胃穹窿部大弯に3型病変と，CTで胃壁の肥厚と肝臓の多発結節影および右肺下葉の腫瘤を指摘され，胃癌の多発転移と考え加療した．また傾眠傾向を認め腫瘍性の副甲状腺ホルモン関連蛋白（PTHrP）上昇とそれにともなう高Ca血症が原因と考えられた．入院後急激に状態が悪化し16日目に永眠された．病理解剖後の組織診断で右肺下葉原発の肺多形癌の，胃を含 …
- NAID 10030803085
Related Links
- Primary hyperparathyroidism is usually caused by a parathyroid adenoma, occasionally by primary parathyroid hyperplasia, and rarely by a parathyroid carcinoma or parathyroid cyst, and very rarely by ectopic secretion of parathyroid ...
- Parathyroid carcinoma is a rare malignancy of the parathyroid glands. These tumors usually secrete parathyroid hormone, thereby producing hyperparathyroidism, which is usually severe. Parathyroid carcinoma may be suspected, but it usually cannot be confirmed prior to operation. This complicates the ...
Related Pictures
★リンクテーブル★
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副甲状腺腫瘍、副甲状腺新生物、上皮小体腫瘍、上皮小体新生物
- 関
- parathyroid adenoma、parathyroid cancer、parathyroid carcinoma、parathyroid tumor
[★]
- 英
- parathyroid carcinoma
- 同
- 上皮小体癌
- 関
- 副甲状腺
[★]
- 関
- parathyroid gland