パラメタゾン。酢酸パラメタゾン
WordNet
- a salt or ester of acetic acid (同)ethanoate
 
PrepTutorEJDIC
- 酢酸(さくさん)塩;アセテート(酢酸人造絹糸)
 
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/12/02 13:01:56」(JST)
[Wiki en表示]
Paramethasone
 | 
| Systematic (IUPAC) name | 
| (6α,11β,16α)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione | 
| Clinical data | 
| AHFS/Drugs.com | 
International Drug Names | 
| Legal status | 
 ? 
 | 
| Identifiers | 
| CAS number | 
53-33-8 Y | 
| ATC code | 
H02AB05 | 
| PubChem | 
CID 5875 | 
| DrugBank | 
DB01384 | 
| ChemSpider | 
5664 Y | 
| UNII | 
VFC6ZX3584 Y | 
| ChEMBL | 
CHEMBL1579 Y | 
| Synonyms | 
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one | 
| Chemical data | 
| Formula | 
C22H29FO5  | 
| Mol. mass | 
392.461 g/mol | 
SMILES 
- O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](F)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)[C@@H](C[C@@H]23)C)C)C
 
 
 
 | 
InChI 
- 
InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1 Y 
Key:MKPDWECBUAZOHP-AFYJWTTESA-N Y 
 
 
 
 | 
|  N (what is this?)  (verify) | 
Paramethasone is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties.
See also
- Glucocorticoid
 
- Corticosteroid
 
References
- Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995)
 
- Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999)
 
- Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);
 
| 
 Corticosteroids – glucocorticoids and mineralocorticoids (H02) 
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B) 
 | 
 
 | 
 
Mineralocorticoids 
(3-one, 4-ene, 
 
no FG at 16) | 
- Pregnenedione: ALDOSTERONE
 
- 11-DEOXYCORTICOSTERONE
 
- HALOGENATED AT 9: Fludrocortisone
 
 
 
 | 
 
 | 
 
Glucocorticoids 
(3-one, 4-ene, 
11-FG, 
 
17-hydroxy) | 
| 
 Pregnene 
 | 
 | 
 
 | 
 
| 
 Pregnenedione 
(+20-one) 
 | 
- HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate
 
- Hydrocortisone buteprate
 
- Hydrocortisone butyrate)
 
- Budesonide
 
- Ciclesonide
 
- Deflazacort
 
- Medrysone
 
- Tixocortol
 
- HALOGENATED AT 6: Cloprednol
 
- HALOGENATED, WITH FG AT 16: Halcinonide
  
 
 
 | 
 
 | 
 
| 
 Pregnadiene (+1-ene) 
 | 
- Rimexolone
 
- HALOGENATED, WITH FG AT 16: Flunisolide
 
- Triamcinolone
 
- Amcinonide
 
- Fluocinolone acetonide (Fluocinonide)
 
 
 
 | 
 
 | 
 
| 
 Pregnadienediol 
(+21-hydroxy) 
 | 
- Prednisone (Meprednisone)
 
- HALOGENATED AT 9: Fluorometholone
 
- HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone
 
- Diflucortolone
 
- Fluocortin)
 
- Desoximetasone
 
 
 
 | 
 
 | 
 
| 
 Pregnadienetriol 
(+11-hydroxy) 
 | 
- Prednisolone# (Methylprednisolone
 
- Methylprednisolone aceponate
 
- Prednicarbate
 
- Prednylidene)
 
- Desonide
 
- HALOGENATED: Fluprednisolone (Difluprednate
 
- Fluperolone)
 
- HALOGENATED, WITH FG AT 16: Dexamethasone#
 
- Betamethasone (Clobetasol
 
- Clobetasone
 
- Diflorasone
 
- Halometasone
 
- Ulobetasol)
 
- Beclometasone
 
- Paramethasone
 
- Alclometasone
 
- Fluclorolone acetonide
 
- Flumetasone
 
- Fluprednidene
 
 
 
 | 
 
 | 
 
| 
 Pregnatriene 
(+2-ene) 
 | 
 | 
 
 | 
 
| 
 Androstene 
 | 
- HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate
 
- Fluticasone furoate)
 
 
 
 | 
 
 | 
 
| 
 Other/ungrouped 
 | 
- HALOGENATED: Loteprednol
 
- HALOGENATED, WITH FG AT 16: Fludroxycortide
 
- Formocortal
 
- Mometasone furoate
 
 
 
 | 
 
 
 | 
 
 | 
 
| Aldosterone antagonists | 
- Spironolactone
 
- Eplerenone
 
- Potassium canrenoate
 
- Canrenone
 
 
 
 | 
 
 | 
 
| Synthesis modifiers | 
- Trilostane
 
- Carbenoxolone
 
- Aminoglutethimide
 
- Metyrapone
 
 
 
 | 
 
 | 
 
- #WHO-EM
 
- ‡Withdrawn from market
 
- Clinical trials:
- †Phase III
 
- §Never to phase III
 
 
 
 
 
 
 | 
 
 | 
 
| 
 | 
 | 
noco (d)/cong/tumr, sysi/epon 
 
 | 
proc, drug (A10/H1/H2/H3/H5) 
 
 | 
 
 
 
 | 
 
 
 | 
 
 
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UpToDate Contents
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English Journal
- Multi-injection plate for intralesional corticosteroid treatment of patchy alopecia areata.
 
- Ferrando J1, Moreno-Arias GA.
 
- Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].Dermatol Surg.2000 Jul;26(7):690-1.
 
- PMID 10886282
 
- Delayed local allergic reaction to intralesional paramethasone acetate.
 
- Miranda-Romero A1, Bajo-del Pozo C, Sánchez-Sambucety P, Martinez-Fernandez M, Garcia-Muñoz M.
 
- Contact dermatitis.Contact Dermatitis.1998 Jul;39(1):31-2.
 
- PMID 9686977
 
- Anaphylactic shock following povidone.
 
- Gonzalo Garijo MA1, Durán Quintana JA, Bobadilla González P, Máiquez Asuero P.
 
- The Annals of pharmacotherapy.Ann Pharmacother.1996 Jan;30(1):37-40.
 
- OBJECTIVE: To report a patient with an anaphylactic reaction related to povidone administration.CASE SUMMARY: A 37-year-old man with a history of allergic rhinitis presented with urticaria, dyspnea, wheezing, rhinorrhea, and dysphonia 20 minutes after the intraarticular administration of mepivacaine
 
- PMID 8773164
 
Japanese Journal
- 高速液体クロマトグラフィーによるコルチコイドの分析第2報, 合成ステロイド剤服用者の血液および尿中ステロイドの分離
 
- ラットにおける合成Glucocorticoidの体内動態
 
- 難治な尋常白斑のParamethasone併用による治療
 
Related Links
- Paramethasone Acetate Paramethasone Acetate may be available in the countries listed below. Ingredient matches for Paramethasone Acetate Paramethasone Paramethasone Acetate (BANM, JAN, USAN) is also ...
 
- Description: Paramethasone Acetate is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties. (Last Updated: 6/27/2016). Synonym: Paramethasone Acetate; UNII-8X50N88ZDP ...
 
★リンクテーブル★
  [★]
- 英
 
- paramethasone、
 
- 同
 
- パラメサゾン
 
- 化
 
- 酢酸パラメタゾン paramethasone acetate
 
[show details]
  [★]
- 英
 
- paramethasone acetate
 
- 関
 
- パラメサゾン、パラメタゾン