パラメタゾン。酢酸パラメタゾン
WordNet
- a salt or ester of acetic acid (同)ethanoate
PrepTutorEJDIC
- 酢酸(さくさん)塩;アセテート(酢酸人造絹糸)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/12/02 13:01:56」(JST)
[Wiki en表示]
Paramethasone
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Systematic (IUPAC) name |
(6α,11β,16α)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
?
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Identifiers |
CAS number |
53-33-8 Y |
ATC code |
H02AB05 |
PubChem |
CID 5875 |
DrugBank |
DB01384 |
ChemSpider |
5664 Y |
UNII |
VFC6ZX3584 Y |
ChEMBL |
CHEMBL1579 Y |
Synonyms |
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
Chemical data |
Formula |
C22H29FO5 |
Mol. mass |
392.461 g/mol |
SMILES
- O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](F)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)[C@@H](C[C@@H]23)C)C)C
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InChI
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InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1 Y
Key:MKPDWECBUAZOHP-AFYJWTTESA-N Y
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N (what is this?) (verify) |
Paramethasone is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties.
See also
- Glucocorticoid
- Corticosteroid
References
- Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995)
- Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999)
- Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);
Corticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)
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Mineralocorticoids
(3-one, 4-ene,
no FG at 16) |
- Pregnenedione: ALDOSTERONE
- 11-DEOXYCORTICOSTERONE
- HALOGENATED AT 9: Fludrocortisone
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Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy) |
Pregnene
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Pregnenedione
(+20-one)
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- HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- HALOGENATED AT 6: Cloprednol
- HALOGENATED, WITH FG AT 16: Halcinonide
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Pregnadiene (+1-ene)
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- Rimexolone
- HALOGENATED, WITH FG AT 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
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Pregnadienediol
(+21-hydroxy)
|
- Prednisone (Meprednisone)
- HALOGENATED AT 9: Fluorometholone
- HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
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Pregnadienetriol
(+11-hydroxy)
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- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- HALOGENATED: Fluprednisolone (Difluprednate
- Fluperolone)
- HALOGENATED, WITH FG AT 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
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Pregnatriene
(+2-ene)
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Androstene
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- HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
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Other/ungrouped
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- HALOGENATED: Loteprednol
- HALOGENATED, WITH FG AT 16: Fludroxycortide
- Formocortal
- Mometasone furoate
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Aldosterone antagonists |
- Spironolactone
- Eplerenone
- Potassium canrenoate
- Canrenone
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Synthesis modifiers |
- Trilostane
- Carbenoxolone
- Aminoglutethimide
- Metyrapone
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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noco (d)/cong/tumr, sysi/epon
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proc, drug (A10/H1/H2/H3/H5)
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UpToDate Contents
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English Journal
- Multi-injection plate for intralesional corticosteroid treatment of patchy alopecia areata.
- Ferrando J1, Moreno-Arias GA.
- Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].Dermatol Surg.2000 Jul;26(7):690-1.
- PMID 10886282
- Delayed local allergic reaction to intralesional paramethasone acetate.
- Miranda-Romero A1, Bajo-del Pozo C, Sánchez-Sambucety P, Martinez-Fernandez M, Garcia-Muñoz M.
- Contact dermatitis.Contact Dermatitis.1998 Jul;39(1):31-2.
- PMID 9686977
- Anaphylactic shock following povidone.
- Gonzalo Garijo MA1, Durán Quintana JA, Bobadilla González P, Máiquez Asuero P.
- The Annals of pharmacotherapy.Ann Pharmacother.1996 Jan;30(1):37-40.
- OBJECTIVE: To report a patient with an anaphylactic reaction related to povidone administration.CASE SUMMARY: A 37-year-old man with a history of allergic rhinitis presented with urticaria, dyspnea, wheezing, rhinorrhea, and dysphonia 20 minutes after the intraarticular administration of mepivacaine
- PMID 8773164
Japanese Journal
- 高速液体クロマトグラフィーによるコルチコイドの分析第2報, 合成ステロイド剤服用者の血液および尿中ステロイドの分離
- ラットにおける合成Glucocorticoidの体内動態
- 難治な尋常白斑のParamethasone併用による治療
Related Links
- Paramethasone Acetate Paramethasone Acetate may be available in the countries listed below. Ingredient matches for Paramethasone Acetate Paramethasone Paramethasone Acetate (BANM, JAN, USAN) is also ...
- Description: Paramethasone Acetate is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties. (Last Updated: 6/27/2016). Synonym: Paramethasone Acetate; UNII-8X50N88ZDP ...
★リンクテーブル★
[★]
- 英
- paramethasone、
- 同
- パラメサゾン
- 化
- 酢酸パラメタゾン paramethasone acetate
[show details]
[★]
- 英
- paramethasone acetate
- 関
- パラメサゾン、パラメタゾン