パラメタゾン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/01 09:40:50」(JST)
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Paramethasone
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| Systematic (IUPAC) name |
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(6α,11β,16α)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
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| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Identifiers |
| CAS Registry Number |
53-33-8 Y |
| ATC code |
H02AB05 |
| PubChem |
CID: 5875 |
| DrugBank |
DB01384 N |
| ChemSpider |
5664 Y |
| UNII |
VFC6ZX3584 Y |
| ChEMBL |
CHEMBL1579 Y |
| Synonyms |
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| Chemical data |
| Formula |
C22H29FO5 |
| Molecular mass |
392.461 g/mol |
SMILES
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O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](F)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)[C@@H](C[C@@H]23)C)C)C
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InChI
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InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1 Y
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Key:MKPDWECBUAZOHP-AFYJWTTESA-N Y
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| N (what is this?) (verify) |
Paramethasone is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties.
See also
- Glucocorticoid
- Corticosteroid
References
- Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995)
- Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999)
- Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);
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Glucocorticoids and antiglucocorticoids (H02)
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| Agonists |
| Pregnene |
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| Pregnenedione |
- Hydrocortisone (cortisol)# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- Halogenated at 6: Cloprednol
- Halogenated, with FG at 16: Halcinonide
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| Pregnadiene |
- Rimexolone
- Halogenated, with FG at 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
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| Pregnadienediol |
- Prednisone (Meprednisone)
- Halogenated at 9: Fluorometholone
- Halogenated, with FG at 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
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| Pregnadienetriol |
- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- Halogenated: Fluprednisolone (Difluprednate
- Fluperolone)
- Halogenated, with FG at 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
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| Pregnatriene |
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| Androstene |
- Halogenated, with FG at 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
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| Others/unsorted |
- Halogenated: Loteprednol
- Halogenated, with FG at 16: Fludroxycortide
- Formocortal
- Mometasone furoate
- Promestriene
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Antagonists /
SGRMs |
- Antagonists: Ketoconazole
- Mifepristone
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| Synthesis modifiers |
- Acetoxolone
- Aminoglutethimide
- Carbenoxolone
- Enoxolone
- Ketoconazole
- Metyrapone
- Mitotane
- Trilostane
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of hormones
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| Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
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| Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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Glucocorticoid signaling
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Receptor
(ligands) |
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GR
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Agonists
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Mixed (SEGRAs)
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- Dagrocorat
- Fosdagrocorat
- Mapracorat
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Antagonists
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- 3α-Hydroxytibolone
- 3β-Hydroxytibolone
- Aglepristone
- Asoprisnil
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Guggulsterone
- Ketoconazole
- Lilopristone
- LLY-2707
- Miconazole
- Mifepristone
- Onapristone
- Org 34850
- Pregnenolone 16α-carbonitrile
- Spironolactone
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
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Enzyme
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Modulators
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- See here instead (modulators of 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 11β-HSD, 21-hydroxylase, 11β-hydroxylase, and 18-hydroxylase).
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| Others |
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Precursors/prohormones
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- Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- Pregnenolone sulfate
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- 11-Deoxycorticosterone
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Indirect
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- ACTH (corticotropin)
- CRH
- DHEA
- DHEA sulfate
- Plasma proteins (albumin, transcortin)
- Vasopressin
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See also: Androgenics • Estrogenics • Mineralocorticoids • Progestogenics
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UpToDate Contents
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- 1. 手根管症候群の治療 treatment of carpal tunnel syndrome
English Journal
- Comparison of surgical decompression and local steroid injection in the treatment of carpal tunnel syndrome: 2-year clinical results from a randomized trial.
- Ly-Pen D, Andréu JL, Millán I, de Blas G, Sánchez-Olaso A.SourceCentro de Salud Gandhi, Hospital Universitario Puerta de Hierro Majadahonda, C/Joaquín Rodrigo 2, 28222 Majadahonda, Madrid, Spain.
- Rheumatology (Oxford, England).Rheumatology (Oxford).2012 Aug;51(8):1447-54. doi: 10.1093/rheumatology/kes053. Epub 2012 Mar 30.
- OBJECTIVE: To compare the efficacy of surgical decompression vs local steroid injection in the treatment of idiopathic CTS.METHODS: This is an open, prospective, randomized clinical trial. We studied the effects of surgical decompression vs local steroid injection in 163 wrists with a clinical diagn
- PMID 22467087
- Epidural dextran-40 and paramethasone injection for treatment of spontaneous intracranial hypotension.
- Bel I, Moreno LA, Gomar C.SourceDepartment of Anesthesiology, Intensive Care and Pain Management, Hospital Clínic, Barcelona, Spain. ibelmarc@hotmail.com
- Canadian journal of anaesthesia = Journal canadien d'anesthésie.Can J Anaesth.2006 Jun;53(6):591-4.
- PURPOSE: This report describes treatment with epidural dextran-40 and paramethasone injection of postural headache resulting from spontaneous intracranial hypotension in a pregnant patient.CLINICAL FEATURES: A 39-yr-old pregnant woman consulted the pain clinic for the assessment of a debilitating po
- PMID 16738294
- [Hiccups crisis following paramethasone intraarticular injection].
- Barriocanal Barriocanal AM, Vaqué Cabañas A, Pérez-Andrés R, Olivé Marques A.
- Medicina clínica.Med Clin (Barc).2005 Jun 25;125(4):158.
- PMID 15989860
Japanese Journal
- バラシクロビルによるヘルペス再発抑制療法が有効と思われた多形紅斑の１例
- 武井 怜子,夏秋 優,山西 清文
- 皮膚の科学 9(5), 458-461, 2010
- 62歳，女性。数年前から背部，腰部を中心にそう痒を伴う浸潤性紅斑が出現し，再発を繰り返すため当科を受診した。背部の皮疹の生検所見から多形紅斑と診断した。抗アレルギー薬の内服とステロイド薬の外用，内服で軽快するが，皮疹は再燃を繰り返した。経過中，この皮疹の出現に先行して殿部に単純疱疹を生じることが判明し，単純疱疹に関連した多形紅斑と診断した。バラシクロビルによるヘルペス再発抑制療法を開始したところ， …
- NAID 130004547428
- 四本 秀昭,下川 優子,松尾 昭一,田代 正昭
- 西日本皮膚科 43(1), 32-36, 1981
- 3例を報告した。治療前に血清IgE値は5,000∼15,000U/mlを示し，コルチコステロイドの投与により皮疹の改善に遅れ，徐々に低下してきた。1例で蛍光抗体直接法にてIgEの基底膜への沈着を認めた。また，ヒト皮膚を基質として用いた螢光抗体間接法ではIgEクラスの抗基底膜抗体は3例ともに証明できなかつた。IgG-Fc R<SUP>+</SUP>T細胞を算定したところ，1例 …
- NAID 130004472700
- 四本 秀昭,松尾 昭一,田代 正昭
- 西日本皮膚科 42(1), 35-40, 1980
- … 本症例は, paramethasone 8mg/dayの投与で症状の軽減を認めた。 …
- NAID 130004472634
Related Links
- Drug Acetylsalicylic acid The corticosteroid, paramethasone, may decrease the effect of the salicylate, acetylsalicylic acid. Fosphenytoin The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid ...
- Read more about the pharmacogenomics of paramethasone on PharmGKB. ... Glucocorticoids such as paramethasone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response ...
Related Pictures
★リンクテーブル★
[★]
- 英
- paramethasone、
- 同
- パラメサゾン
- 化
- 酢酸パラメタゾン paramethasone acetate
[show details]
[★]
パラメタゾン。酢酸パラメタゾン