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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/04 23:53:36」(JST)

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Pannus is an abnormal layer of fibrovascular tissue or granulation tissue. Common sites for pannus formation include over the cornea, over a joint surface (as seen in rheumatoid arthritis), or on a prosthetic heart valve. Pannus may grow in a tumor-like fashion, as in joints where it may erode articular cartilage and bone.

The term pannus is often used incorrectly to refer to a panniculus (a hanging flap of tissue).

Pannus in rheumatoid arthritis

The term "pannus" is derived from the Latin for "cloth". Inflammation and exuberant proliferation of the synovium leads to formation of pannus and destruction of cartilage, bone, tendons, ligaments, and blood vessels.^[1] Basically, the hypertrophied synovium is called pannus.^[2] Pannus tissue is composed of aggressive macrophage- and fibroblast-like mesenchymal cells, macrophage-like cells and other inflammatory cells that release collagenolytic enzymes.^[3]

In people suffering from rheumatoid arthritis, pannus tissue eventually forms in the joint affected by the disease, causing loss of bone and cartilage. From Autoimmunity and Disease by Harley Y. Tse and Michail K. Shaw:

“

Chronic stages of the disease typically coincide with the formation of a structure known as a pannus. A pannus is a membrane of granulation tissue composed of mesenchyme- and bone marrow-derived cells. Formation of the pannus stimulates the release of IL-1, platelet-derived growth factor, prostaglandins, and substance P by macrophages, which ultimately cause cartilage destruction and bone erosion.

”

Pannus in ophthalmology

In ophthalmology, pannus refers to the growth of blood vessels into the peripheral cornea. In normal individuals, the cornea is avascular. Chronic local hypoxia (such as that occurring with overuse of contact lenses) or inflammation may lead to peripheral corneal vascularization, or pannus. Pannus may also develop in diseases of the corneal stem cells, such as aniridia. It is often resolved by peritomy.

References

^ "Rheumatoid Arthritis: Practice Essentials, Background, Pathophysiology".
^ "RA Pathophysiology". www.hopkinsarthritis.org. Retrieved 2015-12-05.
^ Furuzawa-Carballeda, J.; Macip-Rodríguez, P.M.; Cabral, A.R. (2008). "Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response". Retrieved December 5, 2015.

UpToDate Contents

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1. 脂肪織炎：認識および診断 panniculitis recognition and diagnosis
2. 慢性関節リウマチにおける滑膜異常 synovial pathology in rheumatoid arthritis
3. カンジダ性間擦疹 candidal intertrigo
4. 人工心臓弁の合併症 complications of prosthetic heart valves
5. 心臓人工弁の心エコー評価 echocardiographic evaluation of prosthetic heart valves

English Journal

Amine functional hydrogels as selective substrates for corneal epithelialization.

Hassan E1, Deshpande P1, Claeyssens F1, Rimmer S2, MacNeil S3.
Acta biomaterialia.Acta Biomater.2014 Jul;10(7):3029-37. doi: 10.1016/j.actbio.2014.02.043. Epub 2014 Mar 4.
The aim of this study was to develop a synthetic hydrogel to act as a corneal substitute capable of selectively supporting the adhesion and proliferation of limbal epithelial cells (LECs) while inhibiting growth of limbal fibroblasts. Deficiency of LECs causes conjunctival epithelial cells to move o
PMID 24607855

Eleutheroside E Ameliorates Arthritis Severity in Collagen-Induced Arthritis Mice Model by Suppressing Inflammatory Cytokine Release.

He C1, Chen X, Zhao C, Qie Y, Yan Z, Zhu X.
Inflammation.Inflammation.2014 Jun 12. [Epub ahead of print]
Rheumatoid arthritis is the most common arthritis and is mainly characterized by symmetric polyarticular joint disorders. Eleutheroside E (EE), a principal active constituent of Acanthopanax senticosus, is reported to have anti-inflammatory effect by inhibiting NF-κB activities. However, the effect
PMID 24917466

Comparative analysis of fresh and dry preserved amniotic membrane transplantation in partial limbal stem cell deficiency.

Chugh JP1, Jain P, Sen R.
International ophthalmology.Int Ophthalmol.2014 Jun 5. [Epub ahead of print]
To compare the role of fresh and dry preserved amniotic membrane transplantation (AMT) in partial limbal stem cell deficiency (LSCD). 30 Patients of partial LSCD involving <180° of cornea of different age group were divided into 2 groups; group A and B. Clinical diagnosis was made on the basis o
PMID 24898773

Japanese Journal

Evaluation of Prosthetic Valve Obstruction on Electrocardiographically Gated Multidetector-Row Computed Tomography : Identification of Subprosthetic Pannus in the Aortic Position

UEDA Tomohiro,TESHIMA Hideki,FUKUNAGA Shuji,AOYAGI Shigeaki,TANAKA Hiroyuki
Circulation journal : official journal of the Japanese Circulation Society 77(2), 418-423, 2013-01-25
NAID 10031138920

Evaluation of Prosthetic Valve Obstruction on Electrocardiographically Gated Multidetector-Row Computed Tomography:– Identification of Subprosthetic Pannus in the Aortic Position –

Ueda Tomohiro,Teshima Hideki,Fukunaga Shuji,Aoyagi Shigeaki,Tanaka Hiroyuki
Circulation Journal 77(2), 418-423, 2013
… At reoperation, presence of subprosthetic pannus was confirmed in all of the 9 patients, but no periprosthetic thrombus was found. … The mean CT attenuation of the subprosthetic pannus was 170 HU, and it was significantly greater than that obtained from the interventricular septum (108 HU; …
NAID 130001870139

Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis

FUJISHIRO Maki,NOZAWA Kazuhisa,KAWASAKI Mikiko,YAMAGUCHI Ayako,IWABUCHI Kazuhisa,YANAGIDA Mitsuaki,SUZUKI Fujihiko,MIYAZAWA Keiji,FUKUI Hirokazu,KANEKO Kazuo,OGAWA Hideoki,TAKAMORI Kenji,TAKASAKI Yoshinari,SEKIGAWA Iwao
Modern rheumatology 22(2), 228-237, 2012-04-01
NAID 10030615061

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