パニペネム
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/29 04:35:34」(JST)
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Panipenem
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Systematic (IUPAC) name |
(5R,6S)-3-{[(3S)-1-ethanimidoylpyrrolidin-3-yl]sulfanyl}- 6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene- 2-carboxylic acid |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
CAS number |
87726-17-8 Y |
ATC code |
J01DH55 (with betamipron) |
PubChem |
CID 72015 |
UNII |
W9769W09JF N |
ChEMBL |
CHEMBL339323 N |
Chemical data |
Formula |
C15H21N3O4S |
Mol. mass |
339.40 g/mol |
N (what is this?) (verify)
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Panipenem (INN) is a carbapenem antibiotic used in combination with betamipron.
See also[edit]
Antibacterials: cell envelope antibiotics (J01C-J01D)
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Intracellular |
- inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
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Glycopeptide |
- inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
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β-lactams/
(inhibit PBP
cross-links) |
Penicillins
(penams)
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Extended sp.
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- aminopenicillins: Amoxicillin#
- Ampicillin# (Pivampicillin
- Hetacillin
- Bacampicillin
- Metampicillin
- Talampicillin)
- Epicillin
- carboxypenicillins: Carbenicillin (Carindacillin)
- Ticarcillin
- Temocillin
- ureidopenicillins: Azlocillin
- Piperacillin
- Mezlocillin
- other: Mecillinam (Pivmecillinam)
- Sulbenicillin
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Narrow sp.
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β-lactamase sensitive
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- Benzylpenicillin (G)#: Clometocillin
- Benzathine benzylpenicillin#
- Procaine benzylpenicillin#
- Azidocillin
- Penamecillin
- Phenoxymethylpenicillin (V)#: Propicillin
- Benzathine phenoxymethylpenicillin
- Pheneticillin
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β-lactamase resistant
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- Cloxacillin# (Dicloxacillin
- Flucloxacillin)
- Oxacillin
- Meticillin
- Nafcillin
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Penems
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Carbapenems
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- Biapenem
- Ertapenem
- antipseudomonal (Doripenem
- Imipenem
- Meropenem)
- Panipenem
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Cephalosporins/Cephamycins
(cephems)
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1st (PEcK)
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- Cefazolin#
- Cefacetrile
- Cefadroxil
- Cefalexin
- Cefaloglycin
- Cefalonium
- Cefaloridine
- Cefalotin
- Cefapirin
- Cefatrizine
- Cefazedone
- Cefazaflur
- Cefradine
- Cefroxadine
- Ceftezole
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2nd (HEN)
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- Cefaclor
- Cefamandole
- Cefminox
- Cefonicid
- Ceforanide
- Cefotiam
- Cefprozil
- Cefbuperazone
- Cefuroxime
- Cefuzonam
- cephamycin (Cefoxitin
- Cefotetan
- Cefmetazole)
- carbacephem (Loracarbef)
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3rd
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- Cefixime#
- Ceftriaxone#
- antipseudomonal (Ceftazidime#
- Cefoperazone)
- Cefcapene
- Cefdaloxime
- Cefdinir
- Cefditoren
- Cefetamet
- Cefmenoxime
- Cefodizime
- Cefotaxime
- Cefpimizole
- Cefpiramide
- Cefpodoxime
- Cefsulodin
- Cefteram
- Ceftibuten
- Ceftiolene
- Ceftizoxime
- oxacephem (Flomoxef
- Latamoxef ‡)
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4th (antips-)
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- Cefepime
- Cefozopran
- Cefpirome
- Cefquinome
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5th
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- Ceftobiprole
- Ceftaroline fosamil
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Veterinary
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- Ceftiofur
- Cefquinome
- Cefovecin
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Monobactams
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- Aztreonam
- Tigemonam
- Carumonam
- Nocardicin A
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β-lactamase inh.
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- penam (Sulbactam
- Tazobactam)
- clavam (Clavulanic acid)
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Combinations
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- Amoxicillin/clavulanic acid#
- Imipenem/cilastatin#
- Ampicillin/flucloxacillin
- Ampicillin/sulbactam (Sultamicillin)
- Piperacillin/tazobactam
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Other |
- polymyxins/detergent (Colistin
- Polymyxin B)
- depolarizing (Daptomycin)
- hydrolyze NAM-NAG (Lysozyme)
- Gramicidin
- Isoniazid
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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gr+f/gr+a (t)/gr-p (c)/gr-o
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drug (J1p, w, n, m, vacc)
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English Journal
- Real-time monitoring of antimicrobial use density to reduce antimicrobial resistance through the promotion of antimicrobial heterogeneity in a haematology/oncology unit.
- Murata S1, Mushino T1, Hosoi H1, Kuriyama K1, Kurimoto M1, Watanuki J1, Nishikawa A1, Sonoki T1, Nakakuma H1, Hanaoka N2.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2015 Sep;70(9):2661-4. doi: 10.1093/jac/dkv151. Epub 2015 Jun 12.
- BACKGROUND: In haematology/oncology units, the frequent and heavy use of broad-spectrum antimicrobials can lead to outbreaks of antimicrobial resistance. Increasing antimicrobial heterogeneity might be a useful strategy for preventing such resistance.METHODS: A real-time antimicrobial use density (A
- PMID 26071518
- [Sensitivity surveillance of Streptococcus pneumoniae isolates for several antibacterial agents in Gifu and Aichi prefectures (2011-2012)].
- Funatsu T, Mizunaga S, Fukuda Y, Nomura N, Hashido H, Mitsuyama J, Hatano M, Yamaoka K, Watanabe K, Asano Y, Suematsu H, Sawamura H, Matsukawa Y, Ohta H, Yamagishi Y, Mikamo H, Matsubara S, Shibata N; Working Group of Total Anti-biogram Study Group; Research Laboratories; Development Division; Toyama Chemical Co Ltd.
- The Japanese journal of antibiotics.Jpn J Antibiot.2015 Aug;68(4):225-42.
- We investigated the susceptibility to antibacterial agents, genotype of penicillin-binding protein (PBP) genes and macrolide resistant genes, and the serotypes against 270 strains of Streptococcus pneumoniae isolated from medical facilities in Gifu and Aichi prefectures between October 2011 and Apri
- PMID 26625536
- Antibiotic Susceptibilities of Pseudomonas aeruginosa Isolated from Blood Samples and Antibiotic Utilization in a University Hospital in Japan.
- Kato I1, Fujimoto F, Higurashi Y, Yamaguchi R, Takayama K, Suzuki M, Okugawa S, Okazaki M, Moriya K.
- Infectious diseases and therapy.Infect Dis Ther.2015 Jun;4(2):213-8. doi: 10.1007/s40121-015-0066-x. Epub 2015 May 20.
- INTRODUCTION: Pseudomonas aeruginosa is one of the most important causes of nosocomial infection. Several reports indicated a correlation of antimicrobial usages and declined susceptibilities. In this report, we evaluated their relation in a tertiary care teaching hospital in Tokyo, Japan for 4 yea
- PMID 25991512
Japanese Journal
- ガッセル神経節の高周波熱凝固後に急性化膿性髄膜炎を発症した1例
- 橋本 孝太郎,中川 雅之,中野 裕子,佐藤 薫,村川 雅洋
- 日本ペインクリニック学会誌 advpub(0), 1108260045, 2011
- われわれはがん性痛に対してガッセル神経節の高周波熱凝固を行った後に急性化膿性髄膜炎が生じた症例を報告する.50歳の男性で,右下顎の歯肉癌による痛みに対してガッセル神経節の高周波熱凝固を行った.右下顎の痛みは軽減したが,同日の深夜より強い頭痛と39°Cの発熱が起こった.明らかな髄膜刺激徴候はなかったが,4日後の脳脊髄液検査で細胞数増加,蛋白濃度の上昇,糖濃度の低下があり,細菌性髄膜炎が疑われた.パニ …
- NAID 130001002795
- Clinical features and subdural lesions in childhood onset Haemophilus influenzae meningitis
- George Imataka1,Atsushi Yoshida2,Keiko Tsukada1,Satomi Koyama1,Naoto Shimura1,Keitaro Fukushima1,Osamu Arisaka1
- Dokkyo journal of medical sciences 37(3), 173-180, 2010-10-25
- … Combined with cefotaxime sodium (CTX) and ampicillin(ABPC) were used in 3 patients for the initial antibiotics, panipenem/betamipron( PAPM/BP) in 2,meropenem hydrate( MEPM) in 1, MEPM + ceftriaxone sodium( CTRX) in 1, and concomitant use of dexamethasonein 7 paitents. …
- NAID 110007860935
Related Links
- Panipenem / Betamipron [PAPM/BP] パニペネム/ベタミプロン, カルバペネム系 1. 商品名 先発品 カルベニン点滴用0.25g/カルベニン点滴用0.5g 【第一三共】 2. 日本における発売年 1993(平成5)年 3. 特長 グラム陽性・陰性 ,嫌気性 ...
- Panipenem is a medicine available in a number of countries worldwide. A list of US medications equivalent to Panipenem is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on more ...
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