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Myeloperoxidase and oxidation of uric acid in gout: implications for the clinical consequences of hyperuricaemia.

Stamp LK1, Turner R1, Khalilova IS1, Zhang M1, Drake J1, Forbes LV1, Kettle AJ2.
Rheumatology (Oxford, England).Rheumatology (Oxford).2014 Jun 4. pii: keu218. [Epub ahead of print]
OBJECTIVES: The aims of this study were to establish whether, in patients with gout, MPO is released from neutrophils and urate is oxidized to allantoin and if these effects are attenuated by allopurinol.METHODS: MPO, urate, allantoin and oxypurinol were measured in plasma from 54 patients with gout
PMID 24899662

Vascular xanthine oxidoreductase contributes to the antihypertensive effects of sodium nitrite in L-NAME hypertension.

Montenegro MF, Pinheiro LC, Amaral JH, Ferreira GC, Portella RL, Tanus-Santos JE.
Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2014 Jun;387(6):591-8.
Nitrate and nitrite have emerged as an important novel source of nitric oxide (NO). We have previously demonstrated that sodium nitrite is an antihypertensive compound that exerts antioxidant effects in experimental hypertension. These unpredicted antioxidant effects of nitrite raised the question w
PMID 24658348

Stamp LK, Barclay M.
Rheumatology (Oxford, England).Rheumatology (Oxford).2014 Jun;53(6):988-97.
Rapid and effective suppression of inflammation is a primary goal in the treatment of rheumatic diseases. However, the therapeutic effect of most medications may be slow to manifest, in the order of weeks or months in the case of DMARDs. Monitoring of drug concentrations allows the possibility of ap
PMID 24196384

Impairment by Hypoxia or Hypoxia/Reoxygenation of Nitric Oxide–Mediated Relaxation in Isolated Monkey Coronary Artery: the Role of Intracellular Superoxide

Tawa Masashi,Yamamizu Kohei,Geddawy Ayman,Shimosato Takashi,Imamura Takeshi,Ayajiki Kazuhide,Okamura Tomio
Journal of Pharmacological Sciences 116(2), 188-196, 2011
… Under combined treatment of apocynin with oxypurinol (xanthine oxidase inhibitor), rotenone (mitochondria electron transport inhibitor), or both, hypoxic impairment of vasorelaxation was restored more effectively. … Similarly, impairment of the nitroglycerin-induced vasorelaxation under hypoxia/reoxygenation was restored by combined treatment with three inhibitors, apocynin, oxypurinol, and rotenone. …
NAID 130000835863

Measurement of urinary oxypurinol by high performance liquid chromatography-tandem mass spectrometry

STOCKER Sophie L.,FRANKLIN Michael E.,ANDERSON Jacqueline M.,PILLANS Peter I.,WILLIAMS Kenneth M.,MCLACHLAN Andrew J.,DAY Richard O.,TAYLOR Paul J.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(25), 2363-2368, 2010-09-01
NAID 10028040796

リンク元	「オキシプリノール」「alloxanthine」

Oxypurinol
Names
	Preferred IUPAC name 1,2-Dihydropyrazolo[4,3-e]pyrimidine-4,6-dione
	Systematic IUPAC name 1H,2H,4H,5H,6H-pyrazolo[3,4-d]pyrimidine-4,6-dione
	Other names 1H,2H,5H-pyrazolo[3,4-d]pyrimidine-4,6-dione; Alloxanthine
Identifiers
CAS Registry Number	2465-59-0
Beilstein Reference	139956
ChEBI	CHEBI:28315
ChEMBL	ChEMBL859
ChemSpider	4483
EC number	219-570-9
	InChI InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11); Key: HXNFUBHNUDHIGC-UHFFFAOYSA-N ;
Jmol-3D images	Image
KEGG	C07599
MeSH	Oxypurinol
PubChem	4644
	SMILES O=C1NC(=O)C2=CNNC2=N1 ;
UNII	G97OZE5068
Properties
Chemical formula	C5H4N4O2
Molar mass	152.11086
Appearance	white crystals
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references