関: oxypurinol

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/26 00:19:38」(JST)

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Oxypurinol is an inhibitor of xanthine oxidase. It is an active metabolite of allopurinol and it is cleared renally. In cases of renal disease, this metabolite will accumulate to toxic levels. By inhibiting xanthine oxidase, it reduces uric acid production. High serum uric acid levels may result in gout, kidney stones, and other medical conditions.

References

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English Journal

Febuxostat improves outcome in a rat model of cancer cachexia.

Konishi M1, Pelgrim L2,3, Tschirner A2, Baumgarten A2, von Haehling S1,4, Palus S1, Doehner W5, Anker SD1, Springer J1,4.
Journal of cachexia, sarcopenia and muscle.J Cachexia Sarcopenia Muscle.2015 Jun;6(2):174-80. doi: 10.1002/jcsm.12017. Epub 2015 Apr 21.
BACKGROUND: Activity of xanthine oxidase is induced in cancer cachexia, and its inhibition by allopurinol or oxypurinol improves survival and reduces wasting in the Yoshida hepatoma cancer cachexia model. Here, we tested the effects of the second-generation xanthine oxidase inhibitor febuxostat comp
PMID 26136193

Oxypurinol-Specific T Cells Possess Preferential TCR Clonotypes and Express Granulysin in Allopurinol-Induced Severe Cutaneous Adverse Reactions.

Chung WH1, Pan RY2, Chu MT3, Chin SW1, Huang YL1, Wang WC4, Chang JY4, Hung SI5.
The Journal of investigative dermatology.J Invest Dermatol.2015 May 6. doi: 10.1038/jid.2015.165. [Epub ahead of print]
Allopurinol, a first-line drug for treating gout and hyperuricemia, is one of the leading causes of severe cutaneous adverse reactions (SCARs). To investigate the molecular mechanism of allopurinol-induced SCAR, we enrolled 21 patients (13 Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (T
PMID 25946710

Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial.

Kaandorp JJ1, Benders MJ1, Schuit E2, Rademaker CM3, Oudijk MA1, Porath MM4, Oetomo SB4, Wouters MG5, van Elburg RM6, Franssen MT7, Bos AF7, de Haan TR8, Boon J9, de Boer IP9, Rijnders RJ10, Jacobs CJ10, Scheepers LH11, Gavilanes DA11, Bloemenkamp KW12, Rijken M12, van Meir CA13, von Lindern JS13, Huisjes AJ14, Bakker SC14, Mol BW7, Visser GH1, Van Bel F1, Derks JB1.
Archives of disease in childhood. Fetal and neonatal edition.Arch Dis Child Fetal Neonatal Ed.2015 May;100(3):F216-23. doi: 10.1136/archdischild-2014-306769. Epub 2014 Dec 15.
OBJECTIVE: To determine whether maternal allopurinol treatment during suspected fetal hypoxia would reduce the release of biomarkers associated with neonatal brain damage.DESIGN: A randomised double-blind placebo controlled multicentre trial.PATIENTS: We studied women in labour at term with clinical
PMID 25512466

Japanese Journal

Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus

Structure 10, 115-125, 2002
NAID 30005693120

「oxypurinol」

Oxypurinol
Names
	Preferred IUPAC name 1,2-Dihydropyrazolo[4,3-e]pyrimidine-4,6-dione
	Systematic IUPAC name 1H,2H,4H,5H,6H-pyrazolo[3,4-d]pyrimidine-4,6-dione
	Other names 1H,2H,5H-pyrazolo[3,4-d]pyrimidine-4,6-dione; Alloxanthine
Identifiers
CAS Number	2465-59-0
Beilstein Reference	139956
ChEBI	CHEBI:28315
ChEMBL	ChEMBL859
ChemSpider	4483
EC Number	219-570-9
Jmol 3D model	Interactive image
KEGG	C07599
MeSH	Oxypurinol
PubChem	4644
UNII	G97OZE5068
	InChI InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11) Key: HXNFUBHNUDHIGC-UHFFFAOYSA-N ;
	SMILES O=C1NC(=O)C2=CNNC2=N1 ;
Properties
Chemical formula	C5H4N4O2
Molar mass	152.11086
Appearance	white crystals
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

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alloxanthine