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Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis.

Morrison BL1, Mullendore ME, Stockwin LH, Borgel S, Hollingshead MG, Newton DL.
Cancer medicine.Cancer Med.2013 Oct;2(5):687-700. doi: 10.1002/cam4.107. Epub 2013 Jul 23.
Oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one) and several structurally related molecules have been shown to have in vitro and in vivo antiproliferative activity. This study aims to confirm and extend mechanistic studies by focusing on oxyphenisatin acetate (OXY, NSC 59687), the pro-drug of
PMID 24403234

Novel small molecule drugs inhibit tumor cell metabolism and show potent anti-tumorigenic potential.

Trojel-Hansen C1, Erichsen KD, Christensen MK, Jensen PB, Sehested M, Nielsen SJ.
Cancer chemotherapy and pharmacology.Cancer Chemother Pharmacol.2011 Jul;68(1):127-38. doi: 10.1007/s00280-010-1453-3. Epub 2010 Sep 18.
BACKGROUND: Rapidly dividing tumor cells have an increased demand for nutrients to support their characteristic unabated growth; this demand is met by an increased availability of nutrients such as amino acids through vasculogenesis and by the enhanced cellular entry of nutrients through the upregul
PMID 20852860

Uddin MK1, Reignier SG, Coulter T, Montalbetti C, Grånäs C, Butcher S, Krog-Jensen C, Felding J.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2007 May 15;17(10):2854-7. Epub 2007 Feb 25.
Syntheses and structure-antiproliferative relationship for oxyphenisatin analogues are described. The cell proliferation data showed that the presence of substituents (especially F, Cl, Me, CF(3), and OMe) in the 6- and 7-position of oxyphenisatin markedly enhanced the potency in the MDA-468 cell li
PMID 17368900