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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/17 04:56:48」(JST)

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Oxotremorine is a parasympathomimetic drug that acts as a non-selective muscarinic acetylcholine receptor agonist.^[1]

Oxotremorine produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs.^[2]

References [edit]

^ Tang C, Castoldi AF, Costa LG (April 1993). "Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes". Biochem. Mol. Biol. Int. 29 (6): 1047–54. PMID 8330013.
^ Craig, C. R.; Stitzel, R. E. (2004). Modern Pharmacology. Boston: Little, Brown. p. 149.

English Journal

Effects of galanin subchronic treatment on memory and muscarinic receptors.

Barreda-Gómez G1, Lombardero L1, Giralt MT1, Manuel I1, Rodríguez-Puertas R2.
Neuroscience.Neuroscience.2015 May 7;293:23-34. doi: 10.1016/j.neuroscience.2015.02.039. Epub 2015 Feb 28.
The cholinergic pathways, which originate in the basal forebrain and are responsible for the control of different cognitive processes including learning and memory, are also regulated by some neuropeptides. One of these neuropeptides, galanin (GAL), is involved in both neurotrophic and neuroprotecti
PMID 25732139

Muscarinic receptor-mediated excitation of rat intracardiac ganglion neurons.

Hirayama M1, Ogata M2, Kawamata T3, Ishibashi H4.
Neuropharmacology.Neuropharmacology.2015 Apr 29. pii: S0028-3908(15)00143-4. doi: 10.1016/j.neuropharm.2015.04.014. [Epub ahead of print]
Modulation of the membrane excitability of rat parasympathetic intracardiac ganglion neurons by muscarinic receptors was studied using an amphotericin B-perforated patch-clamp recording configuration. Activation of muscarinic receptors by oxotremorine-M (OxoM) depolarized the membrane, accompanied b
PMID 25937214

Muscarinic acetylcholine receptor in cerebellar cortex participates in acetylcholine-mediated blood depressor response in rats.

Zhou P1, Zhu Q2, Liu M2, Li J2, Wang Y2, Zhang C3, Hua T4.
Neuroscience letters.Neurosci Lett.2015 Apr 23;593:129-33. doi: 10.1016/j.neulet.2015.03.036. Epub 2015 Mar 19.
Our previous investigations have revealed that cerebellar cholinergic innervation is involved in cardiovascular regulation. This study was performed to examine the effects of the muscarinic cholinergic receptor (mAChR) in the cerebellar cortex on blood pressure (BP) modulation in rats. Acetylcholine
PMID 25797185

Japanese Journal

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of pharmacological sciences 117(4), 253-264, 2011-12-20
NAID 10030453700

Demonstration of Muscarinic and Nicotinic Receptor Binding Activities of Distigmine to Treat Detrusor Underactivity

Biological and Pharmaceutical Bulletin 33(4), 653-658, 2010
NAID 130000248014

Tokishakuyakusan : Pharmacological evidence for neuroactive and neuroprotective actions

和漢医薬学雑誌 24(5), 149-155, 2007
NAID 110006437771

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★リンクテーブル★

リンク元	「オキソトレモリン」

「オキソトレモリン」

Oxotremorine
Systematic (IUPAC) name
	1-(4-Pyrrolidin-1-ylbut-2-yn-1-yl)pyrrolidin-2-one
Clinical data
Pregnancy cat.	C
Legal status	Experimental/not yet approved (US)
Routes	Oral, intravenous
Identifiers
CAS number	70-22-4
ATC code	None
IUPHAR ligand	302
ChEMBL	CHEMBL7634
Chemical data
Formula	C12H18N2O
Mol. mass	206.28
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英: oxotremorine
関: アセチルコリン受容体

ムスカリン受容体刺激薬
基底核のムスカリン性アセチルコリン受容体を刺激し、振戦などを引き起こす。

[pmid8330013-1] Tang C, Castoldi AF, Costa LG (April 1993). "Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes". Biochem. Mol. Biol. Int. 29 (6): 1047–54. PMID 8330013.

[2] Craig, C. R.; Stitzel, R. E. (2004). Modern Pharmacology. Boston: Little, Brown. p. 149.

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oxotremorine