WordNet

of or involving the ovaries; "ovarian cancer"
the scar on certain seeds marking its point of attachment to the funicle

PrepTutorEJDIC

卵巣の / 子房(しぼう)の

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 卵巣子宮内膜腫の診断およびマネージメント diagnosis and management of ovarian endometriomas
2. 卵巣癌のスクリーニング screening for ovarian cancer
3. 幼児、小児および思春期における卵巣嚢腫、および腫瘍 ovarian cysts and neoplasms in infants children and adolescents
4. 自己免疫性卵巣機能不全の病因、診断、および治療 pathogenesis diagnosis and treatment of autoimmune ovarian failure
5. 上皮性卵巣癌の早期発見：症状認識の役割 early detection of epithelial ovarian cancer role of symptom recognition

English Journal

Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche.

Flesken-Nikitin A, Hwang CI, Cheng CY, Michurina TV, Enikolopov G, Nikitin AY.Author information Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, New York 14853, USA.AbstractEpithelial ovarian cancer (EOC) is the fifth leading cause of cancer deaths among women in the United States, but its pathogenesis is poorly understood. Some epithelial cancers are known to occur in transitional zones between two types of epithelium, whereas others have been shown to originate in epithelial tissue stem cells. The stem cell niche of the ovarian surface epithelium (OSE), which is ruptured and regenerates during ovulation, has not yet been defined unequivocally. Here we identify the hilum region of the mouse ovary, the transitional (or junction) area between the OSE, mesothelium and tubal (oviductal) epithelium, as a previously unrecognized stem cell niche of the OSE. We find that cells of the hilum OSE are cycling slowly and express stem and/or progenitor cell markers ALDH1, LGR5, LEF1, CD133 and CK6B. These cells display long-term stem cell properties ex vivo and in vivo, as shown by our serial sphere generation and long-term lineage-tracing assays. Importantly, the hilum cells show increased transformation potential after inactivation of tumour suppressor genes Trp53 and Rb1, whose pathways are altered frequently in the most aggressive and common type of human EOC, high-grade serous adenocarcinoma. Our study supports experimentally the idea that susceptibility of transitional zones to malignant transformation may be explained by the presence of stem cell niches in those areas. Identification of a stem cell niche for the OSE may have important implications for understanding EOC pathogenesis.
Nature.Nature.2013 Mar 14;495(7440):241-5. doi: 10.1038/nature11979. Epub 2013 Mar 6.
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer deaths among women in the United States, but its pathogenesis is poorly understood. Some epithelial cancers are known to occur in transitional zones between two types of epithelium, whereas others have been shown to originate in ep
PMID 23467088

Growth patterns of placental and paraovarian adrenocortical heterotopias are different.

Zhong H1, Xu B2, Popiolek DA3.Author information 1Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School and Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.2Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.3Department of Pathology and Laboratory Medicine, New York University School of Medicine, New York, NY 10016, USA.AbstractTwo cases of adrenocortical heterotopia are reported. One is in a full-term placenta. The other is adjacent to the ovarian hilum of an adult. Both are incidental findings. Despite sharing similar histological and immunological features, they show different growth patterns. The literature is reviewed and adrenocortical heterotopias of different locations are compared. New hypotheses of its histogenesis are discussed.
Case reports in pathology.Case Rep Pathol.2013;2013:205692. doi: 10.1155/2013/205692. Epub 2013 Dec 7.
Two cases of adrenocortical heterotopia are reported. One is in a full-term placenta. The other is adjacent to the ovarian hilum of an adult. Both are incidental findings. Despite sharing similar histological and immunological features, they show different growth patterns. The literature is reviewed
PMID 24383032

X-ray computed tomography and sonography features of continuous splenogonadal fusion.

Zhang Y, Tong Z, Zhang Y.Author information Department of Urology, The Military General Hospital of Beijing, Beijing, China. hnandbjzy@gmail.comAbstractSplenogonadal fusion is a rare congenital anomaly where the spleen is attached to either testicular or ovarian tissues. In present case, splenogonadal fusion presents as a large mass consciously connected to atrophic testis in left scrotum. The diagnosis of splenic gonadal fusion relies on radiologic and pathologic findings. Uniform density and vessels connection originating from splenic hilum between principle spleen and let testicle were observed with ultrasound and X-ray computed tomography (CT). Surgical exploration ruled out malignancy, extratesticular scrotal mass with affected testicle was removed. Pathologic examination demonstrated that ectopic spleen tissue and ipsilateral atrophic testis. Our data suggested that orchiectomy should be performed when contralateral testicle is normal and the affected testicular appeared significantly atrophy.
Journal of X-ray science and technology.J Xray Sci Technol.2013;21(2):303-8. doi: 10.3233/XST-130378.
Splenogonadal fusion is a rare congenital anomaly where the spleen is attached to either testicular or ovarian tissues. In present case, splenogonadal fusion presents as a large mass consciously connected to atrophic testis in left scrotum. The diagnosis of splenic gonadal fusion relies on radiologi
PMID 23694917