WordNet

malignant bone tumor; most common in children and young adults where it tends to affect the femur (同)osteogenic_sarcoma

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1. 悪性胸膜中皮腫の病理 pathology of malignant pleural mesothelioma

English Journal

A case of dedifferentiated solitary fibrous tumor of the thoracic cavity.

Masuda Y1, Kurisaki-Arakawa A1, Hara K1, Arakawa A1, Oh S2, Suzuki K2, Yao T1, Saito T1.Author information 1Department of Human Pathology, Juntendo University School of Medicine 2-1-1, Hongo, Bunkyo-ku, Tokyo, Japan.2Department of General Thoracic Surgery, Juntendo University School of Medicine 2-1-1, Hongo, Bunkyo-ku, Tokyo, Japan.AbstractSolitary fibrous tumors (SFTs), initially observed in the pleura, were later found to develop in almost any extrapleural site. Dedifferentiation within SFTs, a rare phenomenon, was characterized only recently, although it was previously described in soft tissue and bone tumors. We report a case of dedifferentiated SFT arising in the right pleura of a 69-year-old man. Computed tomography revealed a huge mass in the thoracic cavity. The tumor contained an area with a high degree of calcification and was heterogeneously enhanced. Macroscopically, the resected tumor was 175×145×135 mm in size. Morphologically and immunohistochemically, this was comprised of a typical SFT juxtaposed to a high-grade component including an osteosarcomatous component. These were sharply demarcated by thin fibrous septa. Furthermore, NAB2-STAT6 fusion transcripts were detected by reverse-transcriptase polymerase chain reaction in both conventional and high-grade components, supporting the concept of a dedifferentiation process in this tumor.
International journal of clinical and experimental pathology.Int J Clin Exp Pathol.2013 Dec 15;7(1):386-93. eCollection 2014.
Solitary fibrous tumors (SFTs), initially observed in the pleura, were later found to develop in almost any extrapleural site. Dedifferentiation within SFTs, a rare phenomenon, was characterized only recently, although it was previously described in soft tissue and bone tumors. We report a case of d
PMID 24427361

Parosteal osteoliposarcoma: a new bone tumor (from imaging to immunophenotype).

Larousserie F1, Chen X, Ding Y, Kreshak J, Cocchi S, Huang X, Niu X, Alberghini M, Vanel D.Author information 1Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Department of Pathology, Rizzoli Institute, Bologna, Italy.AbstractINTRODUCTION: Parosteal osteosarcomas and well-differentiated liposarcomas (WDLPS) of soft tissue share several features: they are slowly progressive, locally aggressive tumors, tend to recur locally, and rarely or never metastasizes if not dedifferentiated. Their treatment is wide surgical resection. Microscopically, both are well differentiated tumors, very like their normal tissue counterpart. They share simple karyotypes with supernumerary ring chromosomes or giant marker chromosomes containing amplified 12q sequences including MDM2 and CDK4 genes, with subsequent overexpression of MDM2 and CDK4 proteins. We present the case of a parosteal osteoliposarcoma made of closely intermingled components of a low-grade osteosarcoma and a WDLPS.
European journal of radiology.Eur J Radiol.2013 Dec;82(12):2149-53. doi: 10.1016/j.ejrad.2011.11.035. Epub 2011 Dec 15.
INTRODUCTION: Parosteal osteosarcomas and well-differentiated liposarcomas (WDLPS) of soft tissue share several features: they are slowly progressive, locally aggressive tumors, tend to recur locally, and rarely or never metastasizes if not dedifferentiated. Their treatment is wide surgical resectio
PMID 22178310

Heterologous osteosarcomatous and rhabdomyosarcomatous elements in dedifferentiated solitary fibrous tumor: further support for the concept of dedifferentiation in solitary fibrous tumor.

Thway K1, Hayes A, Ieremia E, Fisher C.Author information 1Sarcoma Unit, Department of Histopathology, Royal Marsden Hospital, London UK. Electronic address: khin.thway@rmh.nhs.uk.AbstractDedifferentiation within solitary fibrous tumor is a rare and only recently characterized phenomenon. It differs from malignant solitary fibrous tumor in that there is abrupt transition between classical solitary fibrous tumor and the dedifferentiated component. The latter is a high-grade sarcoma, which can exhibit a number of morphologies, but heterologous differentiation is exceptionally rare. We report a case of dedifferentiated solitary fibrous tumor, with heterologous osteosarcomatous and rhabdomyosarcomatous elements, arising in the deep soft tissue of the thigh of a 59-year-old man. This comprised morphologically and immunohistochemically typical solitary fibrous tumor, juxtaposed to pleomorphic, high-grade malignant neoplasm of 2 distinct lineages. The sharp demarcation between well-differentiated and dedifferentiated components is typical of the dedifferentiation seen in other mesenchymal neoplasms. This expands the range of histopathology of this rare, newly characterized type of malignant progression in solitary fibrous tumor.
Annals of diagnostic pathology.Ann Diagn Pathol.2013 Oct;17(5):457-63. doi: 10.1016/j.anndiagpath.2012.08.006. Epub 2012 Oct 3.
Dedifferentiation within solitary fibrous tumor is a rare and only recently characterized phenomenon. It differs from malignant solitary fibrous tumor in that there is abrupt transition between classical solitary fibrous tumor and the dedifferentiated component. The latter is a high-grade sarcoma, w
PMID 23040384