WordNet
- a hand tool used for opening sealed containers (bottles or cans)
- the first event in a series; "she played Chopin for her opener"; "the seasons opener was a game against the Yankees"
- a bottle opener to pry off caps
- without undue constriction as from e.g. tenseness or inhibition; "the clarity and resonance of an open tone"; "her natural and open response"
- a clear or unobstructed space or expanse of land or water; "finally broke out of the forest into the open" (同)clear
- information that has become public; "all the reports were out in the open"; "the facts had been brought to the surface" (同)surface
- a tournament in which both professionals and amateurs may play
- become available; "an opportunity opened up" (同)open_up
- become open; "The door opened" (同)open_up
- cause to open or to become open; "Mary opened the car door" (同)open_up
- make available; "This opens up new possibilities" (同)open_up
- start to operate or function or cause to start operating or functioning; "open a business" (同)open_up
- not sealed or having been unsealed; "the letter was already open"; "the opened package lay on the table" (同)opened
- used of mouth or eyes; "keep your eyes open"; "his mouth slightly opened" (同)opened
- not brought to a conclusion; subject to further thought; "an open question"; "our position on this bill is still undecided"; "our lawsuit is still undetermined" (同)undecided, undetermined, unresolved
- affording unobstructed entrance and exit; not shut or closed; "an open door"; "they left the door open" (同)unfastened
- (set theory) of an interval that contains neither of its endpoints
- accessible to all; "open season"; "an open economy"
- affording free passage or access; "open drains"; "the road is open to traffic"; "open ranks"
- begin or set in action, of meetings, speeches, recitals, etc.; "He opened the meeting with a long speech"
- display the contents of a file or start an application as on a computer
- have an opening or passage or outlet; "The bedrooms open into the hall"
- having no protecting cover or enclosure; "an open boat"; "an open fire"; "open sports cars"
- make the opening move; "Kasparov opened with a standard opening"
- not having been filled; "the job is still open"
- not requiring union membership; "an open shop employs nonunion workers"
- open to or in view of all; "an open protest"; "an open letter to the editor"
- ready for business; "the stores are open"
PrepTutorEJDIC
- 開ける道具 / 開ける人 / (シリーズの)第1試合;(番組などの)最初の出しもの
- 目を見張らせるようなこと,驚くべきこと / 朝目覚ましに飲む飲み物
- (本番前の)練習[試合]
- =can opener
- …‘を'『開く』,開ける;…‘の'ふた(おおい)をとる / …‘を'『切り開いて作る』,開拓する;…‘を'全開通させる《+『名』+『up,』+『名』+『up』》 / …‘を'『広げる』《+『up』+(『out』)+『名,』+『名』+『up』(『out』)》 / …‘を'『始める』 / …‘を'開業する,開店する,開場する / (人に)〈心など〉‘を'打ち明ける,〈秘密など〉‘を'漏らす《+『名』+『to』+『名』》 / (新思想などに)〈心・目〉‘を'開く《+『名』+『to』+『名』》 / 〈戸などが〉『開く』,あく / 〈花・つぼみが〉開く《+『out』》 / 〈学校などが〉『始まる』;〈店などが〉開く / 〈道路などが〉開通する / (…に)向かって開いている,(…に)通じている《+『out』『on』(『upon,to,onto』)+『名』》 / 《副詞[句]を伴って》〈風景などが〉広がる,ひらける / 本を開く;(…)ページを開く《+『to』(《英》『at』)+『名』》 / (窓・口などが)『開いた』,開いている;(包みなどが)広げられて / (花が)咲いた / (店などが)『開いている』,開業している;(催し物が)『公開の』,だれでも入れる / 《名詞の前にのみ用いて》ふたのしてない,屋根のない,おおいのない / 広く開いた,さえぎるものがない / 公然の / 率直な,遠慮しない / さらされている,無防備の / 《補語にのみ用いて》(職・地位などが)空位の;(時間などが)あいている / (問題・議事などが)未解決の / 凍結しない,雪や霜の降らない;温和な / (漁・猟が)解禁の / (音声が)開口音の;開音節の / 《the~》戸外,野外 / 空き地;(樹木のない)開けた場所,平野
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/13 08:18:01」(JST)
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- 1. アルコール摂取と妊娠 alcohol intake and pregnancy
- 2. アルコールおよびその他の薬物の有害な使用のスクリーニング screening for unhealthy use of alcohol and other drugs
- 3. 低カリウム性周期性四肢麻痺 hypokalemic periodic paralysis
- 4. QT短縮症候群 short qt syndrome
- 5. 高齢者の健康維持 geriatric health maintenance
English Journal
- Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the BN Rat.
- Slove S, Lannoy M, Behmoaras J, Pezet M, Sloboda N, Lacolley P, Escoubet B, Buján J, Jacob MP.SourceCHU Xavier Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France. marie-paule.jacob-lenet@inserm.fr.
- Hypertension.Hypertension.2013 Oct;62(4):794-801. doi: 10.1161/HYPERTENSIONAHA.113.01379. Epub 2013 Aug 5.
- Hypertension is a cardiovascular disorder that appears in more than half of the patients with Williams-Beuren syndrome, hemizygous for the elastin gene among 26 to 28 other genes. It was shown that the antihypertensive drug minoxidil, an ATP-dependent potassium channel opener, enhances elastic fiber
- PMID 23918751
- A door opener for future research: agonist-induced β3-adrenoceptor desensitization in HEK cells but not CHO cells.
- Seifert R.SourceInstitute of Pharmacology, Medical School of Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany, seifert.roland@mh-hannover.de.
- Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2013 Oct;386(10):841-2. doi: 10.1007/s00210-013-0884-x. Epub 2013 Jun 12.
- PMID 23756577
- The effect of ezogabine on the pharmacokinetics of an oral contraceptive agent.
- Crean CS, Tompson DJ, Buraglio M.AbstractObjectives: Ezogabine (EZG) is a potassium-channel opener that has been approved as adjunctive treatment for partial-onset seizures in adults with epilepsy. This Phase I clinical study evaluated the pharmacokinetics (PK), safety, and tolerability of coadministration of EZG and a combined oral contraceptive (OC). Methods: An open-label drug-interaction study was conducted in healthy, female volunteers aged 18 - 55 years with regular menstrual cycles. The effects of steady-state 750 mg EZG on the PK of a combined OC agent containing 1 mg norethindrone and 0.035 mg ethinyl estradiol were evaluated, along with the effect of the contraceptive hormones on EZG PK. Safety was evaluated by clinical laboratory, vital sign, electrocardiogram, physical examination, and adverse event (AE) assessments. Results: Of 30 enrolled volunteers, 25 completed all treatments. OC did not affect the PK of EZG. EZG increased norethindrone area under the concentration-time curve (AUC) by 28%, with no change in the maximum plasma concentration (Cmax). Ethinyl estradiol Cmax was 21% lower with no change in AUC. The majority of AEs were mild in severity, with the most commonly reported being gastrointestinal disorders and nervoussystem disorders. No deaths or serious AEs were reported in this study. Five volunteers discontinued treatment due to AEs. Conclusions: EZG did not have any clinically relevant impact on exposure of OC hormones in this study, and the OC hormones did not alter EZG PK parameters. This study provides PK evidence that doses of EZG and OCs do not need to be altered when co-administered.
- International journal of clinical pharmacology and therapeutics.Int J Clin Pharmacol Ther.2013 Sep 17. [Epub ahead of print]
- Objectives: Ezogabine (EZG) is a potassium-channel opener that has been approved as adjunctive treatment for partial-onset seizures in adults with epilepsy. This Phase I clinical study evaluated the pharmacokinetics (PK), safety, and tolerability of coadministration of EZG and a combined oral contra
- PMID 24040852
- KATP Channel Opener Diazoxide Prevents Neurodegeneration: A New Mechanism of Action via Antioxidative Pathway Activation.
- Virgili N, Mancera P, Wappenhans B, Sorrosal G, Biber K, Pugliese M, Espinosa-Parrilla JF.SourceNeurotec Pharma S.L., Bioincubadora PCB-Santander, Parc Científic de Barcelona, Barcelona, Spain.
- PloS one.PLoS One.2013 Sep 11;8(9):e75189. doi: 10.1371/journal.pone.0075189.
- Pharmacological modulation of ATP-sensitive potassium channels has become a promising new therapeutic approach for the treatment of neurodegenerative diseases due to their role in mitochondrial and cellular protection. For instance, diazoxide, a well-known ATP-sensitive potassium channel activator w
- PMID 24040400
Japanese Journal
- トウモロコシ(Zea mays L.)の不耕起播種栽培における土壌物理性が播種精度および初期生育に及ぼす影響
- 森田 聡一郎,中尾 誠司,菅野 勉,黒川 俊二,佐藤 節郎,吉村 義則
- 日本草地学会誌 57(4), 185-189, 2012-01-15
- 飼料二毛作体系下でのトウモロコシ不耕起播種において,土壌物理性が播種精度および初期生育に及ぼす影響を調査するために,トラクタを走行させた試験区(踏圧区)に対しトリプルディスク方式の不耕起播種機を用いて播種を行った。その結果,踏圧区では土壌硬度とせん断抵抗値が増加し,また土壌粒径の増加が確認された。それにあわせ,踏圧区における播種精度の低下はみられなかったものの,苗立率および初期生育はロータリ耕区と …
- NAID 110009426012
- 研究の個性 : ヒットとロングテール, 栓抜きと水道
- 吉武 道子
- 表面科学 : hyomen kagaku = Journal of the Surface Science Society of Japan 32(8), 483-488, 2011-08-10
- NAID 10029597658
- 小笠原諸島西島におけるトクサバモクマオウ林の環境特性
- 川上 和人,阿部 真,青山 夕貴子
- 小笠原研究 36, 1-19, 2011-03
- … We found that the canopy was opener, the litter was thicker, and the soil was drier in Casuarina forests than in native forests. …
- NAID 110008659098
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Related Pictures
★リンクテーブル★
| リンク元 | 「オープナー」「開口固定薬」 |
| 拡張検索 | 「channel opener」 |
| 関連記事 | 「open」 |
「オープナー」
「開口固定薬」
「channel opener」
「open」
- n.
- v.
- 開口する、開放する、開放性の、開放的な