- 関
- olsalazine
WordNet
- a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
PrepTutorEJDIC
- ソジウム,ナトリウム(金属元素;化学記号はNa)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/18 20:52:31」(JST)
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Olsalazine
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Systematic (IUPAC) name |
5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazino]-2-hydroxybenzoic acid
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Clinical data |
Trade names |
Dipentum |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a601088 |
Pregnancy
category |
- US: C (Risk not ruled out)
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Legal status |
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Pharmacokinetic data |
Protein binding |
99% |
Biological half-life |
0.9 hours |
Identifiers |
CAS Registry Number |
15722-48-2 Y |
ATC code |
A07EC03 |
PubChem |
CID: 6003770 |
DrugBank |
DB01250 Y |
ChemSpider |
10642377 Y |
UNII |
ULS5I8J03O Y |
KEGG |
D00727 N |
ChEMBL |
CHEMBL571540 N |
Chemical data |
Formula |
C14H10N2O6 |
Molecular mass |
302.239g/mol |
SMILES
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O=C(O)c1cc(ccc1O)/N=N/c2cc(C(O)=O)c(O)cc2
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InChI
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InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+ Y
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Key:QQBDLJCYGRGAKP-FOCLMDBBSA-N Y
|
N (what is this?) (verify) |
Olsalazine is an anti-inflammatory drug used in the treatment of inflammatory bowel disease such as ulcerative colitis. It is sold under the name Dipentum.
The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.
Like balsalazide, olsalazine is believed to deliver mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is the active site of disease in ulcerative colitis.
Contents
- 1 History
- 2 Supply
- 3 Other indications
- 4 External links
History
Olsalazine gained Food and Drug Administration (FDA) approval in 1990.
Supply
The drug is supplied by UCB Pharma.
Other indications
The Australian biotech company Giaconda has developed a combination therapy for treating constipation-predominant irritable bowel syndrome that uses olsalazine and the anti-gout drug colchicine.
External links
- Olsalazine official site
- Medicine Net
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07)
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Rehydration |
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Intestinal anti-infectives |
- Antibiotics
- Amphotericin B
- Colistin
- Fidaxomicin
- Kanamycin
- Natamycin
- Neomycin
- Nystatin
- Paromomycin
- Polymyxin B
- Rifaximin
- Streptomycin
- Vancomycin
- Sulfonamides
- Phthalylsulfathiazole
- Succinylsulfathiazole
- Sulfaguanidine
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Intestinal adsorbents |
- Charcoal
- Bismuth
- Pectin
- Kaolin
- Crospovidone
- Attapulgite
- Diosmectite
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Antipropulsives (opioids) |
- Opium tincture (laudanum)
- Codeine
- Morphine
- Camphorated opium tincture (paregoric)
- crosses BBB: Diphenoxylate (Diphenoxylate/atropine)
- Difenoxin
- does not cross BBB: Eluxadoline
- Loperamide
|
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Intestinal anti-inflammatory agents |
- corticosteroids acting locally
- Prednisolone
- Hydrocortisone
- Prednisone
- Betamethasone
- Tixocortol
- Budesonide
- Beclometasone
- antiallergic agents, excluding corticosteroids
- aminosalicylic acid and similar agents
- Sulfasalazine
- Mesalazine
- Olsalazine
- Balsalazide
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Antidiarrheal micro-organisms |
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Other antidiarrheals |
- Albumin tannate
- Ceratonia
- Crofelemer
- Octreotide
- Racecadotril
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Index of digestion
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Description |
- Anatomy
- Physiology
- Development
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Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
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Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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UpToDate Contents
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English Journal
- Technetium-99 m labeling and evaluation of olsalazine: a novel agent for ulcerative colitis imaging.
- El-Kawy OA1, Ibrahim IT1, Farah K1.
- Journal of labelled compounds & radiopharmaceuticals.J Labelled Comp Radiopharm.2015 Jun 1. doi: 10.1002/jlcr.3306. [Epub ahead of print]
- Ulcerative colitis is a chronic disease having a regressive nature. Commonly used diagnostic methods have the disadvantage to be invasive, time-consuming, and expensive. Therefore, a new sensitive method for the detection and monitoring of disease activity is urgently needed in clinical practice. In
- PMID 26031480
- On the colonic bacterial metabolism of azo-bonded prodrugsof 5-aminosalicylic acid.
- Sousa T1, Yadav V, Zann V, Borde A, Abrahamsson B, Basit AW.
- Journal of pharmaceutical sciences.J Pharm Sci.2014 Oct;103(10):3171-5. doi: 10.1002/jps.24103. Epub 2014 Aug 4.
- Azo-bonded prodrugs of 5-aminosalicylic acid (mesalazine)-sulfasalazine, balsalazide, and olsalazine, which are used in the treatment of ulcerative colitis, rely on colonic bacteria to cleave the azo bond and liberate the active drug in the large intestine. The aim of this study was to use an in vit
- PMID 25091594
- Role of pharmacoepidemiology studies in addressing pharmacovigilance questions: a case example of pancreatitis risk among ulcerative colitis patients using mesalazine.
- Russo L1, Schneider G, Gardiner MH, Lanes S, Streck P, Rosen S.
- European journal of clinical pharmacology.Eur J Clin Pharmacol.2014 Jun;70(6):709-17. doi: 10.1007/s00228-014-1660-7. Epub 2014 Mar 11.
- PURPOSE: Well-designed pharmacoepidemiology studies address several limitations of postmarketing spontaneous reports in regard to signal evaluation. This study evaluated a signal of disproportionate reporting of acute pancreatitis cases observed in patients with ulcerative colitis (UC) treated with
- PMID 24609467
Japanese Journal
- Experimental colitis induced by dextran sulphate sodium in mice : beneficial effects of sulphasalazine and olsalazine
Related Links
- olsalazine sodium Dipentum Pharmacologic class: Salicylate Therapeutic class: Anti-inflammatory Pregnancy risk category C Action Unknown. Converts to active form, mesalamine, which blocks cyclooxygenase and inhibits ...
- Olsalazine Sodium reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). ... References 1. Celltech. Dipentum (olsalazine) capsules prescribing information. Rochester, NY ...
Related Pictures
★リンクテーブル★
[★]
- 英
- olsalazine
- 同
- オルサラジンナトリウム olsalazine sodium
[★]
- 英
- olsalazine sodium
- 関
- オルサラジン
[★]
オルサラジン
- 同
- Dipentum