オルサラジン
- 同
- Dipentum
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/24 00:25:43」(JST)
[Wiki en表示]
Olsalazine
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Systematic (IUPAC) name |
5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazino]-2-hydroxybenzoic acid |
Clinical data |
Trade names |
Dipentum |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a601088 |
Pregnancy cat. |
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Legal status |
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Pharmacokinetic data |
Protein binding |
99% |
Half-life |
0.9 hours |
Identifiers |
CAS number |
15722-48-2 Y |
ATC code |
A07EC03 |
PubChem |
CID 6003770 |
DrugBank |
DB01250 |
ChemSpider |
10642377 Y |
UNII |
ULS5I8J03O Y |
KEGG |
D00727 N |
ChEMBL |
CHEMBL571540 N |
Chemical data |
Formula |
C14H10N2O6 |
Mol. mass |
302.239g/mol |
SMILES
- O=C(O)c1cc(ccc1O)/N=N/c2cc(C(O)=O)c(O)cc2
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InChI
-
InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+ Y
Key:QQBDLJCYGRGAKP-FOCLMDBBSA-N Y
|
N (what is this?) (verify) |
Olsalazine is an anti-inflammatory drug used in the treatment of inflammatory bowel disease such as ulcerative colitis. It is sold under the name Dipentum.
The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.
Like balsalazide, olsalazine is believed to deliver mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is the active site of disease in ulcerative colitis.
Contents
- 1 History
- 2 Supply
- 3 Other indications
- 4 External links
History
Olsalazine gained Food and Drug Administration (FDA) approval in 1990.
Supply
The drug is supplied by UCB Pharma.
Other indications
The Australian biotech company Giaconda has developed a combination therapy for treating constipation-predominant irritable bowel syndrome that uses olsalazine and the anti-gout drug colchicine.
External links
- Olsalazine official site
- Medicine Net
Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07)
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Rehydration |
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Intestinal anti-infectives |
- Antibiotics
- Amphotericin B
- Colistin
- Fidaxomicin
- Kanamycin
- Natamycin
- Neomycin
- Nystatin
- Paromomycin
- Polymyxin B
- Rifaximin
- Streptomycin
- Vancomycin
- Sulfonamides
- Phthalylsulfathiazole
- Succinylsulfathiazole
- Sulfaguanidine
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Intestinal adsorbents |
- Charcoal
- Bismuth
- Pectin
- Kaolin
- Crospovidone
- Attapulgite
- Diosmectite
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Antipropulsives (opioids) |
- Opium tincture (laudanum)
- Codeine
- Morphine
- Camphorated opium tincture (paregoric)
- crosses BBB: Diphenoxylate (Diphenoxylate/atropine)
- Difenoxin
- does not cross BBB: Loperamide
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Intestinal anti-inflammatory agents |
- corticosteroids acting locally
- Prednisolone
- Hydrocortisone
- Prednisone
- Betamethasone
- Tixocortol
- Budesonide
- Beclometasone
- antiallergic agents, excluding corticosteroids
- aminosalicylic acid and similar agents
- Sulfasalazine
- Mesalazine
- Olsalazine
- Balsalazide
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Antidiarrheal micro-organisms |
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Other antidiarrheals |
- Albumin tannate
- Ceratonia
- Crofelemer
- Octreotide
- Racecadotril
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anat (t, g, p)/phys/devp/enzy
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noco/cong/tumr, sysi/epon
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proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
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UpToDate Contents
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English Journal
- Determination of mesalazine, a low bioavailability olsalazine metabolite in human plasma by UHPLC-MS/MS: Application to a pharmacokinetic study.
- Banda J1, Lakshmanan R2, Katepalli RB2, Reddy Venati UK2, Koppula R2, Shiva Prasad VV2.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2016 Jan 1;1008:1-10. doi: 10.1016/j.jchromb.2015.11.001. Epub 2015 Nov 4.
- Olsalazine sodium, salicylate derivative (prodrug) is effectively bioconverted to mesalazine (5-aminosalicylic acid; 5-ASA), which has an anti-inflammatory activity in ulcerative colitis. In this article, a novel highly sensitive and selective method was developed and validated to determine mesalazi
- PMID 26606108
- Technetium-99 m labeling and evaluation of olsalazine: a novel agent for ulcerative colitis imaging.
- El-Kawy OA1, Ibrahim IT1, Farah K1.
- Journal of labelled compounds & radiopharmaceuticals.J Labelled Comp Radiopharm.2015 Jun 30;58(8):336-41. doi: 10.1002/jlcr.3306. Epub 2015 Jun 1.
- Ulcerative colitis is a chronic disease having a regressive nature. Commonly used diagnostic methods have the disadvantage to be invasive, time-consuming, and expensive. Therefore, a new sensitive method for the detection and monitoring of disease activity is urgently needed in clinical practice. In
- PMID 26031480
- On the colonic bacterial metabolism of azo-bonded prodrugsof 5-aminosalicylic acid.
- Sousa T1, Yadav V, Zann V, Borde A, Abrahamsson B, Basit AW.
- Journal of pharmaceutical sciences.J Pharm Sci.2014 Oct;103(10):3171-5. doi: 10.1002/jps.24103. Epub 2014 Aug 4.
- Azo-bonded prodrugs of 5-aminosalicylic acid (mesalazine)-sulfasalazine, balsalazide, and olsalazine, which are used in the treatment of ulcerative colitis, rely on colonic bacteria to cleave the azo bond and liberate the active drug in the large intestine. The aim of this study was to use an in vit
- PMID 25091594
Japanese Journal
- Experimental colitis induced by dextran sulphate sodium in mice : beneficial effects of sulphasalazine and olsalazine
- Long-term treatment with olsalazine for ulcerative colitis : Safety and relapse prevention : A follow-up study
- Olsalazine as an alternative therapy in a patient with sulfasalazine-induced eosinophilic pneumonia.
Related Links
- Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to olsalazine. Do not let anyone else take your medicine. Ask your pharmacist any questions ...
- Information about the ulcerative colitis drug olsalazine (Dipentum), including side effects, dosage, drug interactions, and pregnancy safety. ... GENERIC NAME: olsalazine BRAND NAME: Dipentum DRUG CLASS AND MECHANISM: ...
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- オルサラジンナトリウム olsalazine sodium
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