English Journal

Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates.

Vengut-Climent E, Terrazas M, Lucas R, Arévalo-Ruiz M, Eritja R, Morales JC.SourceDepartment of Bioorganic Chemistry, Instituto de Investigaciones Químicas, CSIC-Universidad de Sevilla, Americo Vespucio 49, 41092 Sevilla, Spain.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2013 May 28. pii: S0960-894X(13)00660-4. doi: 10.1016/j.bmcl.2013.05.065. [Epub ahead of print]
Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5'-end and the corresponding siRNA duplexes have been prepared using phosphoramidite chemistry. All the carbohydrate-siRNA derivatives were compatible with RNA interference machinery if transfected with oligofectamine. In the absenc
PMID 23764303

Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation.

Bowler FR, Chan CK, Duffy CD, Gerland B, Islam S, Powner MW, Sutherland JD, Xu J.SourceMedical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Nature chemistry.Nat Chem.2013 May;5(5):383-9. doi: 10.1038/nchem.1626. Epub 2013 Apr 14.
The recent synthesis of pyrimidine ribonucleoside-2',3'-cyclic phosphates under prebiotically plausible conditions has strengthened the case for the involvement of ribonucleic acid (RNA) at an early stage in the origin of life. However, a prebiotic conversion of these weakly activated monomers, and
PMID 23609088

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.

Schwoebel F, van Eijk LT, Zboralski D, Sell S, Buchner K, Maasch C, Purschke WG, Humphrey M, Zöllner S, Eulberg D, Morich F, Pickkers P, Klussmann S.SourceNOXXON Pharma AG, Berlin, Germany. fschwoebel@noxxon.com
Blood.Blood.2013 Mar 21;121(12):2311-5. doi: 10.1182/blood-2012-09-456756. Epub 2013 Jan 24.
Anemia of chronic inflammation is the most prevalent form of anemia in hospitalized patients. A hallmark of this disease is the intracellular sequestration of iron. This is a consequence of hepcidin-induced internalization and subsequent degradation of ferroportin, the hepcidin receptor and only kno
PMID 23349391

Japanese Journal

Improved Method for the Solid-Phase Synthesis of Oligoribonucleotide 5′-Triphosphates

Nagata Seigo,Takagaki Kazuchika,Wada Takeshi
Chemical and Pharmaceutical Bulletin 60(9), 1212-1215, 2012
… The improved method can be used to generate oligoribonucleotide 5′-TPs efficiently and reproducibly. …
NAID 130001852536

Microarray-based label-free detection of RNA using bispyrene-modified 2′-O-methyl oligoribonucleotide as capture and detection probe

Sakamoto Takashi,Kobori Akio,Murakami Akira
Bioorganic & Medicinal Chemistry Letters 18(8), 2590-2593, 2008-04-15
… As a capture and detection probe, bispyrene-modified 2'-O-methyl oligoribonucleotide (OMUpy2), whose fluorescence was dramatically increased when hybridized with its complementary RNA, was adopted. … Fluorescence of the OMUpy2 tethered on the glass surface was enhanced as much as 22-fold by the addition of complementary oligoribonucleotide. …
NAID 120001856660

Yoshimura Yoshinaga,Noguchi Yuuki,Fujimoto Kenzo
Organic & Biomolecular Chemistry 5(1), 139-142, 2007-00-00
… We report the nonenzymatic terminal labeling of oligoribonucleotide (ORN) by using template-directed photoligation through 5-carboxyvinyl-2-deoxyuridine (^<CV>U) with high selectivity. …
NAID 120001063260