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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/10 16:29:32」(JST)

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Normetanephrine is a metabolite of norepinephrine created by action of catechol-O-methyl transferase on norepinephrine. It is excreted in the urine and found in certain tissues. It is a marker for catecholamine-secreting tumors such as pheochromocytoma.

Norepinephrine degradation. Normetanephrine is shown at top left. Enzymes are shown in boxes. ^[1]

References

^ Figure 11-4 in: Flower, R.; Rang, H. P.; Dale, M. M.; Ritter, J. M. (2007). Rang & Dale's Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5.

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UpToDate Contents

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1. 褐色細胞腫の臨床症状および診断 clinical presentation and diagnosis of pheochromocytoma
2. フォンヒッペル・リンダウ病の臨床的特徴、診断、およびマネージメント clinical features diagnosis and management of von hippel lindau disease
3. 遺伝的疾患における褐色細胞腫 pheochromocytoma in genetic disorders

English Journal

Monitoring of biogenic amines and drugs of various therapeutic groups in urine samples with use of HPLC.

Baranowska I1, Płonka J1.
Biomedical chromatography : BMC.Biomed Chromatogr.2016 Apr;30(4):652-7. doi: 10.1002/bmc.3614. Epub 2015 Nov 24.
A high-performance liquid chromatography method for simultaneous separation and determination of biogenic amines [dopamine, epinephrine, serotonin and its six metabolites (normetanephrine, metanephrine, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylglycol, homovanilic acid and 5-hydroxyin
PMID 26362402

CHARACTERISTICS AND OUTCOMES OF METASTATIC SDHB AND SPORADIC PHEOCHROMOCYTOMA/PARAGANGLIOMA: AN NATIONAL INSTITUTES OF HEALTH STUDY.

Turkova H, Prodanov T, Maly M, Martucci V, Adams K, Widimsky J Jr, Chen CC, Ling A, Kebebew E, Stratakis CA, Fojo T, Pacak K.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.Endocr Pract.2016 Mar;22(3):302-14. doi: 10.4158/EP15725.OR. Epub 2015 Nov 2.
OBJECTIVE: Overall about 10 to 20% of pheochromocytomas/paragangliomas (PHEOs/PGLs) are metastatic, with higher metastatic potential observed in succinate dehydrogenase subunit B/fumarate hydratase (SDHB/FH)-related tumors. Due to the improved availability of biochemical and genetic testing and the
PMID 26523625

Longitudinal plasma metanephrines preceding pheochromocytoma diagnosis: a retrospective case-control serum repository study.

Olson SW, Yoon S, Baker T1, Prince LK, Oliver D, Abbott KC1.
European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2016 Mar;174(3):289-95. doi: 10.1530/EJE-15-0651. Epub 2015 Dec 15.
OBJECTIVE: Plasma metanephrines (PMN) are highly sensitive for diagnosis of pheochromocytoma, but the natural history of PMN before pheochromocytoma diagnosis has not been previously described. The aim of the study was to compare the progression of PMN before pheochromocytoma diagnosis to matched he
PMID 26671972

Japanese Journal

Diagnostic accuracy of plasma free metanephrines in a seated position compared with 24-hour urinary metanephrines in the investigation of pheochromocytoma

, , , , , , , , , , ,
Endocrine Journal 62(3), 243-250, 2015
… Plasma-free metanephrines were measured by LC-MS/MS. The cut-off values with optimal sensitivity and specificity for plasma metanephrine and plasma normetanephrine were 0.33 nmol/L and 0.61 nmol/L, respectively. …
NAID 130005060858

Diagnostic accuracy of plasma free metanephrines in a seated position compared with 24-hour urinary metanephrines in the investigation of pheochromocytoma

, , , , , , , , , , ,
Endocrine Journal, 2014
… Plasma-free metanephrines were measured by LC-MS/MS. The cut-off values with optimal sensitivity and specificity for plasma metanephrine and plasma normetanephrine were 0.33 nmol/L and 0.61 nmol/L, respectively. …
NAID 130004704368

両側副腎部分切除術を施行し，機能を温存し得た副腎褐色細胞腫の1 例

佐々木理人,増本幸二,新開統子,五藤周,瓜田泰久,上杉達,玉井香菜,福島敬,佐藤泰樹,野口雅之
日本小児外科学会雑誌 50(5), 910-915, 2014
症例は9 歳男児．頭痛，嘔吐，高血圧を契機に両側の副腎腫瘤を指摘された．精査にて両側副腎褐色細胞腫と診断し，術後の副腎機能温存を目的として両側副腎部分切除術を施行した．副腎機能不全を呈することなく，補充していたステロイドは漸減し，術後4 か月目に終了となった．また，術後に遺伝子検査を施行し，von Hippel-Lindau 病と診断した．両側副腎褐色細胞腫に対する副腎部分切除は，術後の副腎機能を …
NAID 130004684303

Related Pictures

★リンクテーブル★

リンク元	「NMN」「ノルメタネフリン」

「NMN」

Normetanephrine
	IUPAC name 4-(2-amino-1-hydroxy-ethyl)- 2-methoxy-phenol
Identifiers
CAS number	97-31-4
PubChem	1237
ChemSpider	1200
MeSH	Normetanephrine
ChEMBL	CHEMBL774
Jmol-3D images	Image 1
	SMILES Oc1ccc(cc1OC)C(O)CN ;
	InChI InChI=1S/C9H13NO3/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-4,8,11-12H,5,10H2,1H3 ; Key: YNYAYWLBAHXHLL-UHFFFAOYSA-N InChI=1/C9H13NO3/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-4,8,11-12H,5,10H2,1H3; Key: YNYAYWLBAHXHLL-UHFFFAOYAR ;
Properties
Molecular formula	C9H13NO3
Molar mass	183.204 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references