WordNet

in a noncompetitive manner; "the scholarships will be awarded noncompetitively"
not involving competition or competitiveness; "noncompetitive positions"; "noncompetitive interest in games"

English Journal

Isoniazid inhibits human erythroid 5-aminolevulinate synthase: Molecular mechanism and tolerance study with four X-linked protoporphyria patients.

Fratz-Berilla EJ1, Breydo L2, Gouya L3, Puy H3, Uversky VN2, Ferreira GC4.
Biochimica et biophysica acta.Biochim Biophys Acta.2016 Nov 10. pii: S0925-4439(16)30293-9. doi: 10.1016/j.bbadis.2016.11.011. [Epub ahead of print]
Mutations in the C-terminus of human erythroid 5-aminolevulinate synthase (hALAS2), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, are associated with two different blood disorders, X-linked sideroblastic anemia (XLSA) and X-linked protoporphyria (XLPP). XLSA-causing mutations yield hALAS2 variant
PMID 27838491

The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B.

Liu X1, Chen DW2, Wu X3, Zhao Z4, Fu ZW3, Huang CT3, Ye LX5, Du Z3, Yu Y2, Fang ZZ6, Sun HZ1.
Phytotherapy research : PTR.Phytother Res.2016 Nov;30(11):1872-1878. doi: 10.1002/ptr.5697. Epub 2016 Aug 18.
Praeruptorin A (PA) and B (PB) are two important compounds isolated from Bai-hua Qian-hu and have been reported to exert multiple biochemical and pharmacological activities. The present study aims to determine the inhibition of PA and PB on the activity of important phase II drug-metabolizing enzyme
PMID 27534594

da Silva SR1, Paiva SL1, Bancerz M2, Geletu M2, Lewis AM2, Chen J3, Cai Y3, Lukkarila JL3, Li H3, Gunning PT4.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2016 Sep 15;26(18):4542-7. doi: 10.1016/j.bmcl.2015.10.015. Epub 2015 Oct 8.
Protein conjugation with ubiquitin and ubiquitin-like small molecules, such as UFM1, is important for promoting cancer cell survival and proliferation. Herein, the development of the first selective micromolar inhibitor of the UBA5 E1 enzyme that initiates UFM1 protein conjugation is described. This
PMID 27520940