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1. 肝線維症の病因 pathogenesis of hepatic fibrosis
2. 骨格の正常な発達および骨形成ならびに骨吸収の調節 normal skeletal development and regulation of bone formation and resorption
3. Clinical manifestations, diagnosis, and treatment of hereditary nephritis (Alport syndrome)

English Journal

Coexistence of Anti-Glomerular Basement Membrane Antibodies and Anti-Neutrophil Cytoplasmic Antibodies in a Child With Human Leukocyte Antigen Susceptibility and Detailed Antibody Description: A Case Report.

Xie LJ1, Cui Z, Jia XY, Chen Z, Liu XR, Zhao MH.
Medicine.Medicine (Baltimore).2015 Jul;94(29):e1179. doi: 10.1097/MD.0000000000001179.
Anti-glomerular basement membrane (anti-GBM) disease and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis both could cause rapidly progressive glomerulonephritis. The coexistence of ANCAs and anti-GBM antibodies was known as "double positive," which was extremely rare in children. W
PMID 26200622

Microbial production of N-acetyl cis-4-hydroxy-L-proline by coexpression of the Rhizobium L-proline cis-4-hydroxylase and the yeast N-acetyltransferase Mpr1.

Bach TM1, Hara R, Kino K, Ohtsu I, Yoshida N, Takagi H.
Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2013 Jan;97(1):247-57. doi: 10.1007/s00253-012-4204-z. Epub 2012 Jun 16.
The proline analogue cis-4-hydroxy-L-proline (CHOP), which inhibits the biosynthesis of collagen, has been clinically evaluated as an anticancer drug, but its water solubility and low molecular weight limits its therapeutic potential since it is rapidly excreted. In addition, CHOP is too toxic to be
PMID 22707053

Uphill running improves rat Achilles tendon tissue mechanical properties and alters gene expression without inducing pathological changes.

Heinemeier KM1, Skovgaard D, Bayer ML, Qvortrup K, Kjaer A, Kjaer M, Magnusson SP, Kongsgaard M.
Journal of applied physiology (Bethesda, Md. : 1985).J Appl Physiol (1985).2012 Sep 1;113(5):827-36. doi: 10.1152/japplphysiol.00401.2012. Epub 2012 Jul 12.
Overuse Achilles tendinopathy is a common and challenging problem in sports medicine. Little is known about the etiology of this disorder, and the development of a good animal model for overuse tendinopathy is essential for advancing insight into the disease mechanisms. Our aim was to test a previou
PMID 22797314

Japanese Journal

Production of N-acetyl cis-4-hydroxy-L-proline by the yeast N-acetyltransferase Mpr1(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

Journal of bioscience and bioengineering 114(2), 160-165, 2012-08
NAID 110009495422

Morphological, Biochemical and Mechanical Features of the Cranial Cruciate and Lateral Collateral Ligaments in Dogs

Okajimas Folia Anatomica Japonica 83(1), 25-32, 2006
NAID 130004495021

エンドスタチンの関節炎抑制効果

炎症・再生 24(2), 107-112, 2004
NAID 130000165337

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