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English Journal

Inducibility of Atrial Fibrillation After GP Ablations and "Autonomic Blockade": Evidence for the Pathophysiological Role of the Nonadrenergic and Noncholinergic Neurotransmitters.

Liu Y, Scherlag BJ, Fan Y, Varma V, Male S, Chaudhry MA, Huang C, Po SS.SourceDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Journal of cardiovascular electrophysiology.J Cardiovasc Electrophysiol.2013 Feb;24(2):188-95. doi: 10.1111/j.1540-8167.2012.02449.x. Epub 2012 Oct 15.
Autonomic Blockade and Atrial Fibrillation. Background: Recent clinical reports that used cholinergic and adrenergic blockade (CAB) as an alternative to ganglionated plexi (GP) ablation to terminate atrial fibrillation (AF) showed mixed results. We investigated the role of other neurotransmitters
PMID 23066921

The Selective Rho-kinase Inhibitor Azaindole-1 Has Long-lasting Erectile Activity in the Rat.

Lasker GF, Pankey EA, Allain AV, Murthy SN, Stasch JP, Kadowitz PJ.SourceDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Urology.Urology.2013 Feb;81(2):465.e7-465.e14. doi: 10.1016/j.urology.2012.10.039.
OBJECTIVE: To investigate the effects of the selective Rho-associated protein kinase (ROCK) inhibitor azaindole-1 on erectile function under physiologic and pathophysiologic conditions in the rat.METHODS: The effect of intracavernosal (i.c.) injections of azaindole-1 on change in intracavernous pres
PMID 23374844

TRPV4 activation in mouse submandibular gland modulates Ca2+ influx and salivation.

Zhang Y, Catalán MA, Melvin JE.SourceSecretory Mechanisms and Dysfunction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2012 Dec 15;303(12):G1365-72. doi: 10.1152/ajpgi.00366.2012. Epub 2012 Oct 18.
Transient receptor potential vanilloid subtype 4 (TRPV4) is a ligand-gated nonselective cation channel that participates in the transduction of mechanical and osmotic stimuli in different tissues. TRPV4 is activated by endogenous arachidonic acid metabolites, 4α-phorbol-12,13 didecanoate, GSK101679
PMID 23086916