関: nizofenone fumarate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/04 07:06:33」(JST)

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Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.^[1]^[2]^[3]^[4]

References

^ Ohta T, Kikuchi H, Hashi K, Kudo Y. Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study. Journal of Neurosurgery. 1986 Mar;64(3):420-6. PMID 3512795
^ Yasuda H, Izumi N, Nakanishi M, Maruyama Y. Brain protection against oxygen deficiency by nizofenone. Advances in Experimental Medicine and Biology. 1988;222:403-10. PMID 3364265
^ Yasuda H, Nakajima A. Brain protection against ischemic injury by nizofenone. Cerebrovascular and Brain Metabolism Reviews. 1993 Winter;5(4):264-76. PMID 8110594
^ Matsumoto Y, Aihara K, Kamata T, Goto N. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. European Journal of Pharmacology. 1994 Sep 1;262(1-2):157-61. PMID 7813567

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English Journal

Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice.

Liu Y1, Zhuang X, Gou L, Ling X, Tian X, Liu L, Zheng Y, Zhang L, Yin X.
Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2013 Jan;103(3):474-80. doi: 10.1016/j.pbb.2012.09.009. Epub 2012 Sep 28.
PMID 23026061

Pharmacological evidence for a correlation between hippocampal CA1 cell damage and hyperlocomotion following global cerebral ischemia in gerbils.

Katsuta K1, Umemura K, Ueyama N, Matsuoka N.
European journal of pharmacology.Eur J Pharmacol.2003 Apr 25;467(1-3):103-9.
PMID 12706462

Effect of ozagrel on locomotor and motor coordination after transient cerebral ischemia in experimental animal models.

Ichikawa K1, Tazawa S, Hamano S, Kojima M, Hiraku S.
Pharmacology.Pharmacology.1999 Nov;59(5):257-65.
PMID 10529658

Japanese Journal

破裂脳動脈瘤の術後管理:vasospasm lag の問題を中心として

脳卒中の外科 23(4), 291-296, 1995
NAID 130004668492

脳動脈瘤破裂後の脳血管攣縮に対する Nizofenone の効果 : 補体系との関連についての考察

日本外科宝函 60(2), 135-139, 1991-03-01
NAID 120005698127

脳血管攣縮に対するトロンボキサン合成酵素阻害剤と Nizofenone の有効性について

脳卒中の外科 19(2), 269-273, 1991
NAID 130004668279

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★リンクテーブル★

リンク元	「ニゾフェノン」
拡張検索	「nizofenone fumarate」

「ニゾフェノン」

Nizofenone
Systematic (IUPAC) name
	(2-chlorophenyl)(2-{2-[(diethylamino)methyl]-1H-imidazol-1-yl}-5-nitrophenyl)methanone
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	54533-85-6
ATC code	N06BX10
PubChem	CID 4514
ChemSpider	4357
UNII	7A2NOC3R88
Chemical data
Formula	C21H21ClN4O3
Molecular mass	412.869 g/mol
	SMILES Clc1ccccc1C(=O)c3cc([N+]([O-])=O)ccc3n2ccnc2CN(CC)CC;
	InChI InChI=1S/C21H21ClN4O3/c1-3-24(4-2)14-20-23-11-12-25(20)19-10-9-15(26(28)29)13-17(19)21(27)16-7-5-6-8-18(16)22/h5-13H,3-4,14H2,1-2H3 ; Key:WZGBZLHGOVJDET-UHFFFAOYSA-N ;
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