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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/06/11 10:36:38」(JST)

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Nipradilol is a beta blocker and nitric oxide donor.^[1]

References

^ Inoue, K; Kei Noguchi, K; Masumoto, M; Wakakura, G (2011). "Effect of five years of treatment with nipradilol eye drops in patients with normal tension glaucoma". Clinical ophthalmology (Auckland, N.Z.). 5: 1211–6. doi:10.2147/OPTH.S23233. PMC 3180485. PMID 21966188.

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English Journal

Nipradilol promotes axon regeneration through S-nitrosylation of PTEN in retinal ganglion cells.

Koriyama Y1, Kamiya M, Arai K, Sugitani K, Ogai K, Kato S.
Advances in experimental medicine and biology.Adv Exp Med Biol.2014;801:751-7. doi: 10.1007/978-1-4614-3209-8_94.
Nipradilol (Nip) is registered as an anti-glaucoma agent. More recently, a protective effect of Nip has been demonstrated in retinal ganglion cells (RGCs) mediated by S-nitrosylation of antioxidative-related Keap1 protein due to its nitric oxide (NO)-donating effect. It also has been reported that N
PMID 24664767

Protective action of nipradilol mediated through S-nitrosylation of Keap1 and HO-1 induction in retinal ganglion cells.

Koriyama Y1, Kamiya M, Takadera T, Arai K, Sugitani K, Ogai K, Kato S.
Neurochemistry international.Neurochem Int.2012 Dec;61(7):1242-53. doi: 10.1016/j.neuint.2012.09.004. Epub 2012 Sep 17.
Nipradilol (Nip), which has α1- and β-adrenoceptor antagonist and nitric oxide (NO)-donating properties, has clinically been used as an anti-glaucomatous agent in Japan. NO mediates cellular signaling pathways that regulate physiological functions. The major signaling mechanisms mediated by NO are
PMID 22995787

Risk factors for progression of normal-tension glaucoma under β-blocker monotherapy.

Araie M1, Shirato S, Yamazaki Y, Matsumoto C, Kitazawa Y, Ohashi Y; Nipradilol‐Timolol Study Group.
Acta ophthalmologica.Acta Ophthalmol.2012 Aug;90(5):e337-43. doi: 10.1111/j.1755-3768.2012.02425.x. Epub 2012 May 2.
PURPOSE: To prospectively study prognostic factors for normal-tension glaucoma (NTG) under treatment with topical β-blocker.METHODS: One hundred and forty-six eyes of 146 patients with NTG with a mean untreated intraocular pressure (IOP) of 14 mmHg, mild to moderate visual field damage and mean sph
PMID 22551324

Japanese Journal

Protective action of nipradilol mediated through S-nitrosylation of Keap1 and HO-1 induction in retinal ganglion cells

Koriyama Yoshiki,Kamiya Marie,Takadera Tsuneo,Arai Kunizo,Sugitani Kayo,Ogai Kazuhiro,Kato Satoru
Neurochemistry International 61(7), 1242-1253, 2012-12
… Nipradilol (Nip), which has α1- and β-adrenoceptor antagonist and nitric oxide (NO)-donating properties, has clinically been used as an anti-glaucomatous agent in Japan. … However, denitro-nipradilol, which does not have NO-donating properties, was not protective against oxidative stress. …
NAID 120004966623

Application of target organ dose model: route-to-route and chemical-to-chemical extrapolation of dose

FOO Swee Cheng,SIN Ivan Siang-Meng
日本毒性学会学術年会 39.2(0), AP-3, 2012
… Applying nipradilol toxicity data to route-to-route extrapolation, (LD50/Wbr-bi)route-i=(Ai,j)(LD50/Wbr-bi)route-j, the relative availability between routes are Aip,iv=3.88, Aig,iv=12.55. …
NAID 130005009188

Target organ dose model for extrapolating animal toxicity data to human

FOO Swee-Cheng,SIN Siang-Meng
日本毒性学会学術年会 39.2(0), AP-12, 2012
… Fitting toxicity data of nipradilol (target organ: respiratory system) yields br values of (1) 0.15 for ig; …
NAID 130005009055

Related Pictures

★リンクテーブル★

リンク元

「ニプラジロール」

Nipradilol
Names
	IUPAC name [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl] nitrate
Identifiers
CAS Number	81486-22-8;
3D model (JSmol)	Interactive image;
ChemSpider	65005;
PubChem CID	72006;
	InChI InChI=1S/C15H22N2O6/c1-10(2)16-7-12(18)8-21-14-5-3-4-11-6-13(23-17(19)20)9-22-15(11)14/h3-5,10,12-13,16,18H,6-9H2,1-2H3 Key: OMCPLEZZPVJJIS-UHFFFAOYSA-N;
	SMILES CC(C)NCC(COC1=CC=CC2=C1OCC(C2)O[N+](=O)[O-])O;
Properties
Chemical formula	C15H22N2O6
Molar mass	326.349 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

　　[★]

英: nipradilol
商: ニプラノール、ハイパジール
関: 眼科用剤

[1] Inoue, K; Kei Noguchi, K; Masumoto, M; Wakakura, G (2011). "Effect of five years of treatment with nipradilol eye drops in patients with normal tension glaucoma". Clinical ophthalmology (Auckland, N.Z.). 5: 1211–6. doi:10.2147/OPTH.S23233. PMC 3180485. PMID 21966188.

v t e Adrenergic receptor modulators
α₁	Agonists: 6-FNE Amidephrine Anisodine Buspirone Cirazoline Corbadrine Desglymidodrine Dexisometheptene Dipivefrine Dopamine Droxidopa (L-DOPS) Ephedrine Epinephrine Etilefrine Etilevodopa Ethylnorepinephrine Indanidine Isometheptene L-DOPA (levodopa) L-Phenylalanine L-Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine (drug) Oxymetazoline Phenylephrine Phenylpropanolamine Pseudoephedrine Synephrine Tetryzoline Tiamenidine XP21279 Xylometazoline Antagonists: Abanoquil Adimolol Ajmalicine Alfuzosin Amosulalol Anisodamine Arotinolol Atiprosin Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone) Benoxathian Buflomedil Bunazosin Carvedilol Corynanthine Dapiprazole Domesticine Doxazosin Ergolines (e.g., ergotamine, dihydroergotamine, lisuride, terguride) Etoperidone Eugenodilol Fenspiride Hydroxyzine Indoramin Ketanserin L-765,314 Labetalol mCPP Mepiprazole Metazosin Monatepil Moxisylyte Naftopidil Nantenine Neldazosin Niaprazine Nicergoline Niguldipine Pardoprunox Pelanserin Perlapine Phendioxan Phenoxybenzamine Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione) Piperoxan Prazosin Quinazosin Quinidine Ritanserin Silodosin Spiperone Talipexole Tamsulosin Terazosin Tiodazosin Tolazoline Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin) Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine) Trimazosin Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine) Urapidil WB-4101 Zolertine
α₂	Agonists: (R)-3-Nitrobiphenyline 4-NEMD 6-FNE Amitraz Apraclonidine Brimonidine Cannabivarin Clonidine Corbadrine Detomidine Dexmedetomidine Dihydroergotamine Dipivefrine Dopamine Droxidopa (L-DOPS) Etilevodopa Ephedrine Ergotamine Epinephrine Etilefrine Ethylnorepinephrine Guanabenz Guanfacine Guanoxabenz L-DOPA (levodopa) L-Phenylalanine L-Tyrosine Lofexidine Medetomidine Melevodopa Methyldopa Mivazerol Naphazoline Norepinephrine Oxymetazoline Phenylpropanolamine Piperoxan Pseudoephedrine Rezatomidine Rilmenidine Romifidine Talipexole Tasipimidine Tetrahydrozoline Tiamenidine Tizanidine Tolonidine Urapidil Vatinoxan XP21279 Xylazine Xylometazoline Antagonists: 1-PP Adimolol Amesergide Aptazapine Atipamezole Atypical antipsychotics (e.g., asenapine, brexpiprazole, clozapine, lurasidone, paliperidone, quetiapine, risperidone, zotepine) Azapirones (e.g., buspirone, gepirone, ipsapirone, tandospirone) BRL-44408 Buflomedil Cirazoline Efaroxan Esmirtazapine Fenmetozole Fluparoxan Idazoxan mCPP Mianserin Mirtazapine NAN-190 Olanzapine Pardoprunox Phentolamine Phenoxybenzamine Piperoxan Piribedil Rauwolscine Rotigotine SB-269970 Setiptiline Spiroxatrine Sunepitron Tolazoline Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine) Yohimbine
β	Agonists: Abediterol Alifedrine Amibegron Arbutamine Arformoterol Arotinolol BAAM Bambuterol Befunolol Bitolterol Broxaterol Buphenine Carbuterol Carmoterol Cimaterol Clenbuterol Colterol Corbadrine Denopamine Dipivefrine Dobutamine Dopamine Dopexamine Droxidopa (L-DOPS) Ephedrine Epinephrine Etafedrine Etilefrine Etilevodopa Ethylnorepinephrine Fenoterol Formoterol Hexoprenaline Higenamine Indacaterol Isoetarine Isoprenaline Isoxsuprine L-DOPA (levodopa) L-Phenylalanine L-Tyrosine Levosalbutamol Mabuterol Melevodopa Methoxyphenamine Methyldopa Mirabegron Norepinephrine Orciprenaline Oxyfedrine PF-610355 Phenylpropanolamine Pirbuterol Prenalterol Ractopamine Procaterol Pseudoephedrine Reproterol Rimiterol Ritodrine Salbutamol Salmeterol Solabegron Terbutaline Tretoquinol Tulobuterol Vilanterol Xamoterol XP21279 Zilpaterol Zinterol Antagonists: Acebutolol Adaprolol Adimolol Afurolol Alprenolol Alprenoxime Amosulalol Ancarolol Arnolol Arotinolol Atenolol Befunolol Betaxolol Bevantolol Bisoprolol Bopindolol Bornaprolol Brefonalol Bucindolol Bucumolol Bufetolol Bufuralol Bunitrolol Bunolol Bupranolol Butaxamine Butidrine Butofilolol Capsinolol Carazolol Carpindolol Carteolol Carvedilol Celiprolol Cetamolol Cicloprolol Cinamolol Cloranolol Cyanopindolol Dalbraminol Dexpropranolol Diacetolol Dichloroisoprenaline Dihydroalprenolol Dilevalol Diprafenone Draquinolol Ecastolol Epanolol Ericolol Ersentilide Esatenolol Esprolol Eugenodilol Exaprolol Falintolol Flestolol Flusoxolol Hydroxycarteolol Hydroxytertatolol ICI-118,551 Idropranolol Indenolol Indopanolol Iodocyanopindolol Iprocrolol Isoxaprolol Isamoltane Labetalol Landiolol Levobetaxolol Levobunolol Levomoprolol Medroxalol Mepindolol Metipranolol Metoprolol Moprolol Nadolol Nadoxolol Nebivolol Nifenalol Nipradilol Oxprenolol Pacrinolol Pafenolol Pamatolol Pargolol Penbutolol Pindolol Practolol Primidolol Procinolol Pronethalol Propafenone Propranolol Ridazolol Ronactolol Soquinolol Sotalol Spirendolol SR 59230A Sulfinalol Talinolol Tazolol Tertatolol Tienoxolol Tilisolol Timolol Tiprenolol Tolamolol Toliprolol Xibenolol Xipranolol

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nipradilol